Listeriolysin O‐induced stimulation of mucin exocytosis in polarized intestinal mucin‐secreting cells: evidence for toxin recognition of membrane‐associated lipids and subsequent toxin internalization through caveolae

Lysteriolysin O (LLO) induces a microtubule‐dependent activation of mucin exocytosis in the human mucin‐secreting HT29‐MTX. Cholesterol inhibits the LLO‐induced mucin exocytosis, whereas the oxidized form of cholesterol had no inhibitory effect. LLO‐induced mucin exocytosis inhibited by cholesterol...

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Veröffentlicht in:	Cellular microbiology 2000-12, Vol.2 (6), p.487-504
Hauptverfasser:	Coconnier, Marie‐Hélène, Lorrot, Mathie, Barbat, Alain, Laboisse, Christian, Servin, Alain L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Toxins Caco-2 Cells Caveolae - physiology Cell Line Cell Membrane Permeability Cell Polarity - physiology Cholesterol - metabolism Cholesterol - pharmacology Exocytosis - drug effects Fluorescent Antibody Technique Heat-Shock Proteins - pharmacology Hemolysin Proteins Humans Intestinal Mucosa - cytology Intestinal Mucosa - physiology Membrane Lipids - metabolism Microscopy, Electron Microtubules Mucins - physiology
Online-Zugang:	Volltext
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