Regulation of intestinal glucose transport by tea catechins
Intestinal glucose uptake is mainly performed by its specific transporters, such as SGLT 1, GLUT 2 and 5 expressed in the intestinal epithelial cells. By using human intestinal epithelial Caco‐2 cells we observed that intestinal glucose uptake was markedly inhibited by tea extracts. While several su...
Gespeichert in:
| Veröffentlicht in: | BioFactors (Oxford) 2000, Vol.13 (1-4), p.61-65 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 65 |
|---|---|
| container_issue | 1-4 |
| container_start_page | 61 |
| container_title | BioFactors (Oxford) |
| container_volume | 13 |
| creator | Shimizu, Makoto Kobayashi, Yoko Suzuki, Miho Satsu, Hideo Miyamoto, Yusei |
| description | Intestinal glucose uptake is mainly performed by its specific transporters, such as SGLT 1, GLUT 2 and 5 expressed in the intestinal epithelial cells. By using human intestinal epithelial Caco‐2 cells we observed that intestinal glucose uptake was markedly inhibited by tea extracts. While several substances in green tea seem to be involved in this inhibition, catechins play the major role and epicatechin gallate (ECg) showed the highest inhibitory activity. Since our Caco‐2 cells did not express enough amount of SGLT 1, the most abundant intestinal glucose transporter, the effect of ECg on SGLT 1 was evaluated by using brush border membrane vesicles obtained from the rabbit small intestine. ECg inhibited SGLT 1 in a competitive manner, although ECg itself was not transported via the glucose transporters. These results suggest that tea catechins could play a role in controlling the dietary glucose uptake at the intestinal tract and possibly contribute to blood glucose homeostasis. |
| doi_str_mv | 10.1002/biof.5520130111 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72579925</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72579925</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4491-6e17f657728cca5745e1455c4f6195cab0f742159d05ad89b87579fdc5bb582d3</originalsourceid><addsrcrecordid>eNqFkMFPwjAYRxujEUTP3sxO3gZt165tOCkKYlCiwZh4abquw-rYsN2i_PeOjGg8efou7_fy5QFwimAfQYgHiS2zPqUYoggihPZAF3GGQw452gddKCgKYxJFHXDk_RvcUoQfgg5COGLNqAuGj2ZZ56qyZRGUWWCLyvjKFioPlnmtS2-CyqnCr0tXBckmqIwKtKqMfrWFPwYHmcq9OdndHngaXy9GN-FsPpmOLmahJkQ0DxjEspgyhrnWijJCDSKUapLFSFCtEpgxghEVKaQq5SLhjDKRpZomCeU4jXrgvPWuXflRN__JlfXa5LkqTFl7yXDDC0wbcNCC2pXeO5PJtbMr5TYSQbntJbe95G-vZnG2U9fJyqS__C5QAwxb4NPmZvOfT15O5-M_-rBdW1-Zr5-1cu8yZhGj8vl-Im_vXsjDYiHkVfQNO_qGNw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72579925</pqid></control><display><type>article</type><title>Regulation of intestinal glucose transport by tea catechins</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Shimizu, Makoto ; Kobayashi, Yoko ; Suzuki, Miho ; Satsu, Hideo ; Miyamoto, Yusei</creator><creatorcontrib>Shimizu, Makoto ; Kobayashi, Yoko ; Suzuki, Miho ; Satsu, Hideo ; Miyamoto, Yusei</creatorcontrib><description>Intestinal glucose uptake is mainly performed by its specific transporters, such as SGLT 1, GLUT 2 and 5 expressed in the intestinal epithelial cells. By using human intestinal epithelial Caco‐2 cells we observed that intestinal glucose uptake was markedly inhibited by tea extracts. While several substances in green tea seem to be involved in this inhibition, catechins play the major role and epicatechin gallate (ECg) showed the highest inhibitory activity. Since our Caco‐2 cells did not express enough amount of SGLT 1, the most abundant intestinal glucose transporter, the effect of ECg on SGLT 1 was evaluated by using brush border membrane vesicles obtained from the rabbit small intestine. ECg inhibited SGLT 1 in a competitive manner, although ECg itself was not transported via the glucose transporters. These results suggest that tea catechins could play a role in controlling the dietary glucose uptake at the intestinal tract and possibly contribute to blood glucose homeostasis.</description><identifier>ISSN: 0951-6433</identifier><identifier>EISSN: 1872-8081</identifier><identifier>DOI: 10.1002/biof.5520130111</identifier><identifier>PMID: 11237201</identifier><language>eng</language><publisher>Amsterdam: IOS Press</publisher><subject>absorption ; Animals ; Biological Transport - drug effects ; Catechin - pharmacology ; catechins ; Food ; Glucose - metabolism ; Glucose transporters ; Humans ; Intestinal Absorption - drug effects ; intestinal cells ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - physiology ; Intestine, Small ; Microvilli - drug effects ; Microvilli - metabolism ; Rabbits ; Tea ; Tumor Cells, Cultured</subject><ispartof>BioFactors (Oxford), 2000, Vol.13 (1-4), p.61-65</ispartof><rights>Copyright © 2000 International Union of Biochemistry and Molecular Biology, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4491-6e17f657728cca5745e1455c4f6195cab0f742159d05ad89b87579fdc5bb582d3</citedby><cites>FETCH-LOGICAL-c4491-6e17f657728cca5745e1455c4f6195cab0f742159d05ad89b87579fdc5bb582d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbiof.5520130111$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbiof.5520130111$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11237201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimizu, Makoto</creatorcontrib><creatorcontrib>Kobayashi, Yoko</creatorcontrib><creatorcontrib>Suzuki, Miho</creatorcontrib><creatorcontrib>Satsu, Hideo</creatorcontrib><creatorcontrib>Miyamoto, Yusei</creatorcontrib><title>Regulation of intestinal glucose transport by tea catechins</title><title>BioFactors (Oxford)</title><addtitle>BioFactors</addtitle><description>Intestinal glucose uptake is mainly performed by its specific transporters, such as SGLT 1, GLUT 2 and 5 expressed in the intestinal epithelial cells. By using human intestinal epithelial Caco‐2 cells we observed that intestinal glucose uptake was markedly inhibited by tea extracts. While several substances in green tea seem to be involved in this inhibition, catechins play the major role and epicatechin gallate (ECg) showed the highest inhibitory activity. Since our Caco‐2 cells did not express enough amount of SGLT 1, the most abundant intestinal glucose transporter, the effect of ECg on SGLT 1 was evaluated by using brush border membrane vesicles obtained from the rabbit small intestine. ECg inhibited SGLT 1 in a competitive manner, although ECg itself was not transported via the glucose transporters. These results suggest that tea catechins could play a role in controlling the dietary glucose uptake at the intestinal tract and possibly contribute to blood glucose homeostasis.</description><subject>absorption</subject><subject>Animals</subject><subject>Biological Transport - drug effects</subject><subject>Catechin - pharmacology</subject><subject>catechins</subject><subject>Food</subject><subject>Glucose - metabolism</subject><subject>Glucose transporters</subject><subject>Humans</subject><subject>Intestinal Absorption - drug effects</subject><subject>intestinal cells</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - physiology</subject><subject>Intestine, Small</subject><subject>Microvilli - drug effects</subject><subject>Microvilli - metabolism</subject><subject>Rabbits</subject><subject>Tea</subject><subject>Tumor Cells, Cultured</subject><issn>0951-6433</issn><issn>1872-8081</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFPwjAYRxujEUTP3sxO3gZt165tOCkKYlCiwZh4abquw-rYsN2i_PeOjGg8efou7_fy5QFwimAfQYgHiS2zPqUYoggihPZAF3GGQw452gddKCgKYxJFHXDk_RvcUoQfgg5COGLNqAuGj2ZZ56qyZRGUWWCLyvjKFioPlnmtS2-CyqnCr0tXBckmqIwKtKqMfrWFPwYHmcq9OdndHngaXy9GN-FsPpmOLmahJkQ0DxjEspgyhrnWijJCDSKUapLFSFCtEpgxghEVKaQq5SLhjDKRpZomCeU4jXrgvPWuXflRN__JlfXa5LkqTFl7yXDDC0wbcNCC2pXeO5PJtbMr5TYSQbntJbe95G-vZnG2U9fJyqS__C5QAwxb4NPmZvOfT15O5-M_-rBdW1-Zr5-1cu8yZhGj8vl-Im_vXsjDYiHkVfQNO_qGNw</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Shimizu, Makoto</creator><creator>Kobayashi, Yoko</creator><creator>Suzuki, Miho</creator><creator>Satsu, Hideo</creator><creator>Miyamoto, Yusei</creator><general>IOS Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>Regulation of intestinal glucose transport by tea catechins</title><author>Shimizu, Makoto ; Kobayashi, Yoko ; Suzuki, Miho ; Satsu, Hideo ; Miyamoto, Yusei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4491-6e17f657728cca5745e1455c4f6195cab0f742159d05ad89b87579fdc5bb582d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>absorption</topic><topic>Animals</topic><topic>Biological Transport - drug effects</topic><topic>Catechin - pharmacology</topic><topic>catechins</topic><topic>Food</topic><topic>Glucose - metabolism</topic><topic>Glucose transporters</topic><topic>Humans</topic><topic>Intestinal Absorption - drug effects</topic><topic>intestinal cells</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - physiology</topic><topic>Intestine, Small</topic><topic>Microvilli - drug effects</topic><topic>Microvilli - metabolism</topic><topic>Rabbits</topic><topic>Tea</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimizu, Makoto</creatorcontrib><creatorcontrib>Kobayashi, Yoko</creatorcontrib><creatorcontrib>Suzuki, Miho</creatorcontrib><creatorcontrib>Satsu, Hideo</creatorcontrib><creatorcontrib>Miyamoto, Yusei</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BioFactors (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimizu, Makoto</au><au>Kobayashi, Yoko</au><au>Suzuki, Miho</au><au>Satsu, Hideo</au><au>Miyamoto, Yusei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of intestinal glucose transport by tea catechins</atitle><jtitle>BioFactors (Oxford)</jtitle><addtitle>BioFactors</addtitle><date>2000</date><risdate>2000</risdate><volume>13</volume><issue>1-4</issue><spage>61</spage><epage>65</epage><pages>61-65</pages><issn>0951-6433</issn><eissn>1872-8081</eissn><abstract>Intestinal glucose uptake is mainly performed by its specific transporters, such as SGLT 1, GLUT 2 and 5 expressed in the intestinal epithelial cells. By using human intestinal epithelial Caco‐2 cells we observed that intestinal glucose uptake was markedly inhibited by tea extracts. While several substances in green tea seem to be involved in this inhibition, catechins play the major role and epicatechin gallate (ECg) showed the highest inhibitory activity. Since our Caco‐2 cells did not express enough amount of SGLT 1, the most abundant intestinal glucose transporter, the effect of ECg on SGLT 1 was evaluated by using brush border membrane vesicles obtained from the rabbit small intestine. ECg inhibited SGLT 1 in a competitive manner, although ECg itself was not transported via the glucose transporters. These results suggest that tea catechins could play a role in controlling the dietary glucose uptake at the intestinal tract and possibly contribute to blood glucose homeostasis.</abstract><cop>Amsterdam</cop><pub>IOS Press</pub><pmid>11237201</pmid><doi>10.1002/biof.5520130111</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0951-6433 |
| ispartof | BioFactors (Oxford), 2000, Vol.13 (1-4), p.61-65 |
| issn | 0951-6433 1872-8081 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72579925 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | absorption Animals Biological Transport - drug effects Catechin - pharmacology catechins Food Glucose - metabolism Glucose transporters Humans Intestinal Absorption - drug effects intestinal cells Intestinal Mucosa - drug effects Intestinal Mucosa - physiology Intestine, Small Microvilli - drug effects Microvilli - metabolism Rabbits Tea Tumor Cells, Cultured |
| title | Regulation of intestinal glucose transport by tea catechins |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T10%3A50%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20intestinal%20glucose%20transport%20by%20tea%20catechins&rft.jtitle=BioFactors%20(Oxford)&rft.au=Shimizu,%20Makoto&rft.date=2000&rft.volume=13&rft.issue=1-4&rft.spage=61&rft.epage=65&rft.pages=61-65&rft.issn=0951-6433&rft.eissn=1872-8081&rft_id=info:doi/10.1002/biof.5520130111&rft_dat=%3Cproquest_cross%3E72579925%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72579925&rft_id=info:pmid/11237201&rfr_iscdi=true |