WAM: an improved algorithm for modelling antibodies on the WEB
An improved antibody modelling algorithm has been developed which incorporates significant improvements to the earlier versions developed by Martin et al. (1989, 1991), Pedersen et al. (1992) and Rees et al. (1996) and known as AbM (Oxford Molecular). The new algorithm, WAM (for Web antibody modelli...
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| Veröffentlicht in: | Protein engineering 2000-12, Vol.13 (12), p.819-824 |
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| container_title | Protein engineering |
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| creator | Whitelegg, Nicholas R.J. Rees, Anthony R. |
| description | An improved antibody modelling algorithm has been developed which incorporates significant improvements to the earlier versions developed by Martin et al. (1989, 1991), Pedersen et al. (1992) and Rees et al. (1996) and known as AbM (Oxford Molecular). The new algorithm, WAM (for Web antibody modelling), has been launched as an online modelling service and is located at URL http://antibody.bath.ac.uk. Here we provide a summary only of the important features of WAM. Readers interested in further details are directed to the website, which gives extensive background information on the methods employed. A brief description of the rationale behind some of the newer methodology (specifically, the knowledge-based screens) is also given. |
| doi_str_mv | 10.1093/protein/13.12.819 |
| format | Article |
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(1989, 1991), Pedersen et al. (1992) and Rees et al. (1996) and known as AbM (Oxford Molecular). The new algorithm, WAM (for Web antibody modelling), has been launched as an online modelling service and is located at URL http://antibody.bath.ac.uk. Here we provide a summary only of the important features of WAM. Readers interested in further details are directed to the website, which gives extensive background information on the methods employed. A brief description of the rationale behind some of the newer methodology (specifically, the knowledge-based screens) is also given.</description><subject>Algorithms</subject><subject>Amino Acid Sequence</subject><subject>antibody fragment containing the variable region</subject><subject>antibody modelling algorithm</subject><subject>CDR</subject><subject>complementarity determining region</subject><subject>Computational Biology</subject><subject>Computer Simulation</subject><subject>Databases, Factual</subject><subject>Immunoglobulin G - chemistry</subject><subject>Internet</subject><subject>knowledge-based screens</subject><subject>L1-3 and H1-3</subject><subject>light- and heavy-chain CDRs</subject><subject>Models, Molecular</subject><subject>Molecular Sequence Data</subject><subject>r.m.s.d</subject><subject>Reproducibility of Results</subject><subject>respectively</subject><subject>root mean square deviation</subject><subject>valence force field</subject><subject>VFF</subject><subject>WAM</subject><subject>WEB</subject><issn>0269-2139</issn><issn>1741-0126</issn><issn>1460-213X</issn><issn>1741-0134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1KxDAUhYMoOo4-gBspLlzZMTe_rQtBRR1BEURxcBPaNNXotBmTVvTtjcyg4EZXSeA7J-feg9AW4BHgnO7PvOuMbfeBjoCMMsiX0ACYwCkBOllGA0xE_nXP19B6CM8Y4wznZBWtARCax8cAHd4fXR0kRZvYJrq9mSoppo_O2-6pSWrnk8ZVZjq17WNkOlu6ypqQuDbpnkxyf3q8gVbqYhrM5uIcoruz09uTcXp5fX5xcnSZaiZpl2pZZkwKzApRZlRKSXCNWcmZ5nEOzkQtDMmoZowbQnlFdc01gBSV5ro0FR2i3blvDPnam9CpxgYdkxWtcX1QknCZC8B_ggQzkWfxryHa-QU-u963cQhFCI-xMLAIwRzS3oXgTa1m3jaF_1CA1VcFalGBAqqAqFhB1GwvjPuyMdWPYrHzCOzNAdfP_uWXznEbOvP-LSj8ixKSSq7Gkwc14fQGj68e1DH9BK7vntI</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Whitelegg, Nicholas R.J.</creator><creator>Rees, Anthony R.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>WAM: an improved algorithm for modelling antibodies on the WEB</title><author>Whitelegg, Nicholas R.J. ; Rees, Anthony R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-c7b847604a6b8377720f04b54c5093546f6e283c445e235d3cf5c1176dc5cbed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Algorithms</topic><topic>Amino Acid Sequence</topic><topic>antibody fragment containing the variable region</topic><topic>antibody modelling algorithm</topic><topic>CDR</topic><topic>complementarity determining region</topic><topic>Computational Biology</topic><topic>Computer Simulation</topic><topic>Databases, Factual</topic><topic>Immunoglobulin G - chemistry</topic><topic>Internet</topic><topic>knowledge-based screens</topic><topic>L1-3 and H1-3</topic><topic>light- and heavy-chain CDRs</topic><topic>Models, Molecular</topic><topic>Molecular Sequence Data</topic><topic>r.m.s.d</topic><topic>Reproducibility of Results</topic><topic>respectively</topic><topic>root mean square deviation</topic><topic>valence force field</topic><topic>VFF</topic><topic>WAM</topic><topic>WEB</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitelegg, Nicholas R.J.</creatorcontrib><creatorcontrib>Rees, Anthony R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Protein engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whitelegg, Nicholas R.J.</au><au>Rees, Anthony R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>WAM: an improved algorithm for modelling antibodies on the WEB</atitle><jtitle>Protein engineering</jtitle><stitle>Protein Eng</stitle><addtitle>Protein Eng</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>13</volume><issue>12</issue><spage>819</spage><epage>824</epage><pages>819-824</pages><issn>0269-2139</issn><issn>1741-0126</issn><eissn>1460-213X</eissn><eissn>1741-0134</eissn><abstract>An improved antibody modelling algorithm has been developed which incorporates significant improvements to the earlier versions developed by Martin et al. 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| fulltext | fulltext |
| identifier | ISSN: 0269-2139 |
| ispartof | Protein engineering, 2000-12, Vol.13 (12), p.819-824 |
| issn | 0269-2139 1741-0126 1460-213X 1741-0134 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Algorithms Amino Acid Sequence antibody fragment containing the variable region antibody modelling algorithm CDR complementarity determining region Computational Biology Computer Simulation Databases, Factual Immunoglobulin G - chemistry Internet knowledge-based screens L1-3 and H1-3 light- and heavy-chain CDRs Models, Molecular Molecular Sequence Data r.m.s.d Reproducibility of Results respectively root mean square deviation valence force field VFF WAM WEB |
| title | WAM: an improved algorithm for modelling antibodies on the WEB |
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