Stereocontrolled synthesis of Ψ[CH=CH] dipeptide isosteres
A new Stereocontrolled synthesis of the Ψ[CH=CH] dipeptide isostere is described. They key step of the sequence relies on the stereospecific α‐alkylation of δ‐amino‐γ‐mesyloxy‐α,β‐unsaturated esters. The broad availability of nucleophilic α‐side chains by this method allows the preparation of a wide...
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| Veröffentlicht in: | International Journal of Peptide and Protein Research 1991-09, Vol.38 (3), p.237-241 |
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| container_end_page | 241 |
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| container_issue | 3 |
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| container_title | International Journal of Peptide and Protein Research |
| container_volume | 38 |
| creator | KEMPF, DALE J. WANG, XIU CHUN SPANTON, STEPHEN G. |
| description | A new Stereocontrolled synthesis of the Ψ[CH=CH] dipeptide isostere is described. They key step of the sequence relies on the stereospecific α‐alkylation of δ‐amino‐γ‐mesyloxy‐α,β‐unsaturated esters. The broad availability of nucleophilic α‐side chains by this method allows the preparation of a wide variety of Ψ[CH=CH] isosteres with predictable stereochemistry. |
| doi_str_mv | 10.1111/j.1399-3011.1991.tb01434.x |
| format | Article |
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They key step of the sequence relies on the stereospecific α‐alkylation of δ‐amino‐γ‐mesyloxy‐α,β‐unsaturated esters. 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They key step of the sequence relies on the stereospecific α‐alkylation of δ‐amino‐γ‐mesyloxy‐α,β‐unsaturated esters. The broad availability of nucleophilic α‐side chains by this method allows the preparation of a wide variety of Ψ[CH=CH] isosteres with predictable stereochemistry.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1761370</pmid><doi>10.1111/j.1399-3011.1991.tb01434.x</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0367-8377 |
| ispartof | International Journal of Peptide and Protein Research, 1991-09, Vol.38 (3), p.237-241 |
| issn | 0367-8377 1399-3011 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72578643 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Aliphatic compounds Alkylation Chemistry dipeptide isostere Dipeptides - chemistry Esters - chemistry Exact sciences and technology Models, Molecular Organic chemistry peptidomimetic Preparations and properties Stereoisomerism |
| title | Stereocontrolled synthesis of Ψ[CH=CH] dipeptide isosteres |
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