Long-Term Follow-Up of Patients with Nonischemic Dilated Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators
We analyzed our 10‐year cumulative experience of 40 consecutive patients with idiopathic dilated Cardiomyopathy and associated ventricular tachyarrhythmias, treated with implantable Cardioverter defibrillators. Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50% with n...
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| Veröffentlicht in: | Pacing and clinical electrophysiology 1991-11, Vol.14 (11), p.1905-1910 |
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| container_title | Pacing and clinical electrophysiology |
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| creator | FAZIO, GREGORY VELTRI, ENRICO P. TOMASELLI, GORDON LEWIS, RICHARD GRIFFITH, LAWRENCE S.C. GUARNIERI, THOMAS |
| description | We analyzed our 10‐year cumulative experience of 40 consecutive patients with idiopathic dilated Cardiomyopathy and associated ventricular tachyarrhythmias, treated with implantable Cardioverter defibrillators. Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50% with no defineable etiology. Patient characteristics included: 24 male, mean age 52 years, mean EF = 33%, New York Heart Association Class I–III, presenting syndrome—cardiac arrest (n = 28), syncope/near syncope (n = 12). At 2.5 years mean follow‐up, there were 16 deaths: one operative, three sudden, two incessant ventricular tachycardia/ventricular fibrillation (VT/VF), six heart failure, and four noncardiac. The actuarial mortality at 1 and 4 years was 0% and 14% for sudden death, 11% and 34% for cardiac death. The projected mortality was 52% and 78% for same time intervals (P < 0.01). No useful baseline variable predicted who would or would not receive an ICD shock in follow‐up. ICD therapy appears effective in reducing sudden death mortality in this high risk population. |
| doi_str_mv | 10.1111/j.1540-8159.1991.tb02788.x |
| format | Article |
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Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50% with no defineable etiology. Patient characteristics included: 24 male, mean age 52 years, mean EF = 33%, New York Heart Association Class I–III, presenting syndrome—cardiac arrest (n = 28), syncope/near syncope (n = 12). At 2.5 years mean follow‐up, there were 16 deaths: one operative, three sudden, two incessant ventricular tachycardia/ventricular fibrillation (VT/VF), six heart failure, and four noncardiac. The actuarial mortality at 1 and 4 years was 0% and 14% for sudden death, 11% and 34% for cardiac death. The projected mortality was 52% and 78% for same time intervals (P < 0.01). No useful baseline variable predicted who would or would not receive an ICD shock in follow‐up. ICD therapy appears effective in reducing sudden death mortality in this high risk population.</description><identifier>ISSN: 0147-8389</identifier><identifier>EISSN: 1540-8159</identifier><identifier>DOI: 10.1111/j.1540-8159.1991.tb02788.x</identifier><identifier>PMID: 1721197</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Cardiomyopathy, Dilated - mortality ; Cardiomyopathy, Dilated - therapy ; Death, Sudden - epidemiology ; Death, Sudden, Cardiac - epidemiology ; dilated Cardiomyopathy ; Electric Countershock - instrumentation ; Female ; Follow-Up Studies ; Humans ; implantable Cardioverter defibrillator ; Life Tables ; Male ; Middle Aged ; Prognosis ; Prostheses and Implants ; Regression Analysis ; Risk Factors ; Tachycardia - mortality ; Tachycardia - therapy ; Time Factors</subject><ispartof>Pacing and clinical electrophysiology, 1991-11, Vol.14 (11), p.1905-1910</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4095-d2d0a81923597ea45d63cabd1be57e38b0f47e77e5d47307ee8cb82216e45ad53</citedby><cites>FETCH-LOGICAL-c4095-d2d0a81923597ea45d63cabd1be57e38b0f47e77e5d47307ee8cb82216e45ad53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1540-8159.1991.tb02788.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1540-8159.1991.tb02788.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1721197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FAZIO, GREGORY</creatorcontrib><creatorcontrib>VELTRI, ENRICO P.</creatorcontrib><creatorcontrib>TOMASELLI, GORDON</creatorcontrib><creatorcontrib>LEWIS, RICHARD</creatorcontrib><creatorcontrib>GRIFFITH, LAWRENCE S.C.</creatorcontrib><creatorcontrib>GUARNIERI, THOMAS</creatorcontrib><title>Long-Term Follow-Up of Patients with Nonischemic Dilated Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators</title><title>Pacing and clinical electrophysiology</title><addtitle>Pacing Clin Electrophysiol</addtitle><description>We analyzed our 10‐year cumulative experience of 40 consecutive patients with idiopathic dilated Cardiomyopathy and associated ventricular tachyarrhythmias, treated with implantable Cardioverter defibrillators. Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50% with no defineable etiology. Patient characteristics included: 24 male, mean age 52 years, mean EF = 33%, New York Heart Association Class I–III, presenting syndrome—cardiac arrest (n = 28), syncope/near syncope (n = 12). At 2.5 years mean follow‐up, there were 16 deaths: one operative, three sudden, two incessant ventricular tachycardia/ventricular fibrillation (VT/VF), six heart failure, and four noncardiac. The actuarial mortality at 1 and 4 years was 0% and 14% for sudden death, 11% and 34% for cardiac death. The projected mortality was 52% and 78% for same time intervals (P < 0.01). No useful baseline variable predicted who would or would not receive an ICD shock in follow‐up. ICD therapy appears effective in reducing sudden death mortality in this high risk population.</description><subject>Cardiomyopathy, Dilated - mortality</subject><subject>Cardiomyopathy, Dilated - therapy</subject><subject>Death, Sudden - epidemiology</subject><subject>Death, Sudden, Cardiac - epidemiology</subject><subject>dilated Cardiomyopathy</subject><subject>Electric Countershock - instrumentation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>implantable Cardioverter defibrillator</subject><subject>Life Tables</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Prostheses and Implants</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Tachycardia - mortality</subject><subject>Tachycardia - therapy</subject><subject>Time Factors</subject><issn>0147-8389</issn><issn>1540-8159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkUFv0zAUxy0EGmXwEZAsDtyS2UkcO5yY2q0bVKOHbkhcLCd5JS5JnNkubT4M35VkqcYZX3x47_977-mH0AdKQjq8i11IWUICQVkW0iyjoc9JxIUIjy_Q7Ln0Es0ITXggYpG9Rm-c2xFCUpKwM3RGeURpxmfoz8q0P4MN2AZfm7o2h-C-w2aL18praL3DB-0rfGda7YoKGl3gha6VhxLPlS21aXrTKV_1WLUlfhgSVhf7Wlm8UUXVK2ur3leNVg5vLDzlnoC3TVer1qu8hhPoN1gPFi9gq3Or62GGse4terVVtYN3p_8c3V9fbeY3werb8nZ-uQqKhGQsKKOSKEGzKGYZB5WwMo0LlZc0B8YhFjnZJhw4B1YmPCYcQBS5iCKaQsJUyeJz9HHidtY87sF52Qz3wrBFC2bvJI8Y5yyJhsZPU2NhjXMWtrKzulG2l5TI0Y3cyVGAHAXI0Y08uZHHIfz-NGWfN1D-i04yhvrnqX7QNfT_QZbry_kVzch4SDAhtPNwfEYo-0umPOZMfr9byoevP5aLdP1Fivgv_tqy7g</recordid><startdate>199111</startdate><enddate>199111</enddate><creator>FAZIO, GREGORY</creator><creator>VELTRI, ENRICO P.</creator><creator>TOMASELLI, GORDON</creator><creator>LEWIS, RICHARD</creator><creator>GRIFFITH, LAWRENCE S.C.</creator><creator>GUARNIERI, THOMAS</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199111</creationdate><title>Long-Term Follow-Up of Patients with Nonischemic Dilated Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators</title><author>FAZIO, GREGORY ; VELTRI, ENRICO P. ; TOMASELLI, GORDON ; LEWIS, RICHARD ; GRIFFITH, LAWRENCE S.C. ; GUARNIERI, THOMAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4095-d2d0a81923597ea45d63cabd1be57e38b0f47e77e5d47307ee8cb82216e45ad53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Cardiomyopathy, Dilated - mortality</topic><topic>Cardiomyopathy, Dilated - therapy</topic><topic>Death, Sudden - epidemiology</topic><topic>Death, Sudden, Cardiac - epidemiology</topic><topic>dilated Cardiomyopathy</topic><topic>Electric Countershock - instrumentation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>implantable Cardioverter defibrillator</topic><topic>Life Tables</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Prostheses and Implants</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Tachycardia - mortality</topic><topic>Tachycardia - therapy</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FAZIO, GREGORY</creatorcontrib><creatorcontrib>VELTRI, ENRICO P.</creatorcontrib><creatorcontrib>TOMASELLI, GORDON</creatorcontrib><creatorcontrib>LEWIS, RICHARD</creatorcontrib><creatorcontrib>GRIFFITH, LAWRENCE S.C.</creatorcontrib><creatorcontrib>GUARNIERI, THOMAS</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pacing and clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FAZIO, GREGORY</au><au>VELTRI, ENRICO P.</au><au>TOMASELLI, GORDON</au><au>LEWIS, RICHARD</au><au>GRIFFITH, LAWRENCE S.C.</au><au>GUARNIERI, THOMAS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Follow-Up of Patients with Nonischemic Dilated Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators</atitle><jtitle>Pacing and clinical electrophysiology</jtitle><addtitle>Pacing Clin Electrophysiol</addtitle><date>1991-11</date><risdate>1991</risdate><volume>14</volume><issue>11</issue><spage>1905</spage><epage>1910</epage><pages>1905-1910</pages><issn>0147-8389</issn><eissn>1540-8159</eissn><abstract>We analyzed our 10‐year cumulative experience of 40 consecutive patients with idiopathic dilated Cardiomyopathy and associated ventricular tachyarrhythmias, treated with implantable Cardioverter defibrillators. Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50% with no defineable etiology. Patient characteristics included: 24 male, mean age 52 years, mean EF = 33%, New York Heart Association Class I–III, presenting syndrome—cardiac arrest (n = 28), syncope/near syncope (n = 12). At 2.5 years mean follow‐up, there were 16 deaths: one operative, three sudden, two incessant ventricular tachycardia/ventricular fibrillation (VT/VF), six heart failure, and four noncardiac. The actuarial mortality at 1 and 4 years was 0% and 14% for sudden death, 11% and 34% for cardiac death. The projected mortality was 52% and 78% for same time intervals (P < 0.01). No useful baseline variable predicted who would or would not receive an ICD shock in follow‐up. ICD therapy appears effective in reducing sudden death mortality in this high risk population.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1721197</pmid><doi>10.1111/j.1540-8159.1991.tb02788.x</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0147-8389 |
| ispartof | Pacing and clinical electrophysiology, 1991-11, Vol.14 (11), p.1905-1910 |
| issn | 0147-8389 1540-8159 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cardiomyopathy, Dilated - mortality Cardiomyopathy, Dilated - therapy Death, Sudden - epidemiology Death, Sudden, Cardiac - epidemiology dilated Cardiomyopathy Electric Countershock - instrumentation Female Follow-Up Studies Humans implantable Cardioverter defibrillator Life Tables Male Middle Aged Prognosis Prostheses and Implants Regression Analysis Risk Factors Tachycardia - mortality Tachycardia - therapy Time Factors |
| title | Long-Term Follow-Up of Patients with Nonischemic Dilated Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators |
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