Combination therapy of malignant glioma cells with 2-5A-antisense telomerase RNA and recombinant adenovirus p53

Malignant gliomas of astrocytic origin have commonly expressed several features such as alterations in the tumor-suppressor gene p53 or p16 or the acquisition of telomerase activity, which are distinctive from astrocytes. Therefore, restoration of the tumor-suppressor gene or telomerase inhibition i...

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Veröffentlicht in:	Gene therapy 2000-12, Vol.7 (24), p.2071-2079
Hauptverfasser:	KOMATA, T, KONDO, Y, KOGA, S, KO, S. C, CHUNG, L. W. K, KONDO, S
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-oligoadenylate Adenoviridae - genetics Adenovirus Adenoviruses Animals Antisense oligonucleotides Antisense RNA Antitumor activity Apoptosis Astrocytes Biological and medical sciences Biotechnology Brain tumors Caspase CDKN2 gene Central Nervous System Neoplasms - pathology Central Nervous System Neoplasms - therapy CIP gene Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics Flow Cytometry Fundamental and applied biological sciences. Psychology Gene therapy Genes, p16 Genes, p53 Genetic Therapy - methods Genetic Vectors - administration & dosage Glioma Glioma - pathology Glioma - therapy Glioma cells Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Male Mice Mice, Nude Mutants Neoplasms, Experimental - therapy p16 gene p16 Protein p16CDKN2 gene p21 gene p21WAF1/CIP gene p53 gene p53 Protein RNA, Antisense - administration & dosage Telomerase Telomerase - genetics Tumor Cells, Cultured Tumors WAF1 gene
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