Catalytic heterogenity of polyclonal RNA-hydrolyzing IgM from sera of patients with lupus erythematosus

Various catalytically active IgG antibodies or abzymes have been detected recently in the sera of patients with several autoimmune pathologies including systemic lupus erythematosus (SLE), where their presence is most probably associated with autoimmunization. Here we show for the first time that Ig...

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Veröffentlicht in:	Medical science monitor 2000-05, Vol.6 (3), p.460-470
Hauptverfasser:	Andrievskaya, O A, Buneva, V N, Naumov, V A, Nevinsky, G A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Catalytic - blood Antibodies, Catalytic - isolation & purification Catalysis Humans Immunoglobulin Fab Fragments - blood Immunoglobulin G - blood Immunoglobulin M - blood Immunoglobulin M - isolation & purification Kinetics Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - immunology Reference Values Ribonucleases - metabolism RNA - metabolism Substrate Specificity
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