Selectin GMP-140 (CD62; PADGEM) binds to sialosyl-Le(a) and sialosyl-Le(x), and sulfated glycans modulate this binding

GMP-140 (CD62; PADGEM) is a member of the selectin family expressed highly at the surface of platelets and endothelial cells by agonists such as thrombin or phorbol esters. Previous studies indicate that the lectin domain of GMP-140 recognizes sialosyl-Le(x) (SLex) and to a lesser extent Le(x) (Poll...

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Veröffentlicht in:	Biochemical and biophysical research communications 1991-12, Vol.181 (3), p.1223-1230
Hauptverfasser:	Handa, K, Nudelman, E D, Stroud, M R, Shiozawa, T, Hakomori, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Antigens, CD - metabolism Blood Platelets - physiology Cell Line Chondroitin Sulfates - pharmacology Dextran Sulfate - pharmacology Humans Kinetics Lewis X Antigen - isolation & purification Lewis X Antigen - metabolism Models, Biological Oligosaccharides - isolation & purification Oligosaccharides - metabolism P-Selectin Platelet Activation Platelet Membrane Glycoproteins - metabolism Polysaccharides - pharmacology Thrombin - pharmacology
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