The Dileucine Motif Within the Tail of MPR46 is Required for Sorting of the Receptor in Endosomes

The cytoplasmic tail of MPR46 carries a leucine‐based motif that is required for the sorting of lysosomal enzymes by the receptor. In addition, it is one of three independent, but functionally redundant, internalization signals present in the cytoplasmic tail of MPR46. We have analyzed a mutant of M...

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Veröffentlicht in:	Traffic (Copenhagen, Denmark) Denmark), 2000-08, Vol.1 (8), p.631-640
Hauptverfasser:	Tikkanen, Ritva, Obermüller, Stefanie, Denzer, Kristin, Pungitore, Rodolfo, Geuze, Hans J., Von Figura, Kurt, Höning, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Amino Acid Motifs - physiology Animals Cell Membrane - metabolism Cell Membrane - ultrastructure Cells, Cultured - metabolism clathrin endosome Endosomes - metabolism Endosomes - ultrastructure Golgi Humans Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure Leucine - metabolism mannose‐6‐phosphate receptor Mutation - physiology Protein Transport - physiology Receptor, IGF Type 2 - chemistry Receptor, IGF Type 2 - genetics Receptor, IGF Type 2 - metabolism sorting trans-Golgi Network - metabolism trans-Golgi Network - ultrastructure Transfection
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