Multiple pathways of thrombin-induced platelet activation differentiated by desensitization and a thrombin exosite inhibitor

Recently a thrombin receptor with a unique mechanism of activation was cloned from a megakaryocyte-like cell line (Vu et al., Cell 64 :1057–1068, 1991). Thrombin cleaves a portion of this receptor creating a new N-terminus that acts as a “tethered-ligand” to activate the receptor. A thrombin recepto...

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Veröffentlicht in:	Biochemical and biophysical research communications 1991-12, Vol.181 (2), p.636-643
Hauptverfasser:	Seiler, Steven M., Goldenberg, Harold J., Michel, Inge M., Hunt, John T., Zavoico, George B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Blood coagulation. Blood cells Drug Tolerance Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology Molecular Sequence Data Peptide Fragments - chemistry Peptide Fragments - pharmacology Peptides - pharmacology Platelet Platelet Activation - drug effects Signal Transduction Thrombin - antagonists & inhibitors Thrombin - pharmacology
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