Fidelity of mammalian DNA replication and replicative DNA polymerases

Current models suggest that two or more DNA polymerases may be required for high-fidelity semiconservative DNA replication in eukaryotic cells. In the present study, we directly compare the fidelity of SV40 origin-dependent DNA replication in human cell extracts to the fidelity of mammalian DNA poly...

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Veröffentlicht in:	Biochemistry (Easton) 1991-12, Vol.30 (51), p.11751-11759
Hauptverfasser:	Thomas, David C, Roberts, John D, Sabatino, Ralph D, Myers, Thomas W, Tan, Cheng Keat, Downey, Kathleen M, So, Antero G, Bambara, Robert A, Kunkel, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences DNA - genetics DNA Polymerase II - metabolism DNA Polymerase III DNA Replication DNA-Directed DNA Polymerase - metabolism Escherichia coli - enzymology Escherichia coli - genetics Fundamental and applied biological sciences. Psychology HeLa Cells Humans Models, Genetic Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutation Replication Thymus Gland - enzymology
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