Sensory nerve pathology in amyotrophic lateral sclerosis

A detailed morphometric study was performed on sural nerve biopsies to determine the consistency of sensory nerve pathology in amyotrophic lateral sclerosis (ALS) and to seek a correlation between the severity of peripheral nerve pathology and disease duration. Nerve biopsies from patients with ALS...

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Veröffentlicht in:Acta neuropathologica 1991-01, Vol.82 (4), p.316-320
Hauptverfasser: HEADS, T, POLLOCK, M, ROBERTSON, A, SUTHERLAND, W. H. F, ALLPRESS, S
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container_issue 4
container_start_page 316
container_title Acta neuropathologica
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creator HEADS, T
POLLOCK, M
ROBERTSON, A
SUTHERLAND, W. H. F
ALLPRESS, S
description A detailed morphometric study was performed on sural nerve biopsies to determine the consistency of sensory nerve pathology in amyotrophic lateral sclerosis (ALS) and to seek a correlation between the severity of peripheral nerve pathology and disease duration. Nerve biopsies from patients with ALS consistently showed evidence of early axonal atrophy, increased remyelination and a shift in the diameter distributions curve towards smaller fiber diameters. Importantly, the severity of sensory nerve pathology in ALS patients correlated with disease duration. The peripheral nerve sodium pump concentration of patients was not reduced. It is concluded that an ingravescent dorsal root ganglion neuronopathy is seen in the incipient stages of ALS, preferentially affecting the largest neurons and resulting in turn in progressive axonal atrophy, secondary demyelination-remyelination and finally in nerve fiber degeneration. Etiologically, a parallel involvement of motor and sensory neurons suggests a more widespread metabolic disturbance in ALS than simply "sick" motor neurons.
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subjects Adult
Aged
Amyotrophic Lateral Sclerosis - enzymology
Amyotrophic Lateral Sclerosis - pathology
Binding Sites - drug effects
Biological and medical sciences
Female
Humans
Male
Medical sciences
Microscopy, Electron
Middle Aged
Myelin Sheath - ultrastructure
Neurology
Neurons, Afferent - enzymology
Neurons, Afferent - pathology
Ouabain - metabolism
Sodium-Potassium-Exchanging ATPase - metabolism
Sural Nerve - enzymology
Sural Nerve - metabolism
Sural Nerve - ultrastructure
title Sensory nerve pathology in amyotrophic lateral sclerosis
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