Concanavalin A induced apoptosis in murine macrophage PU5-1.8 cells through clustering of mitochondria and release of cytochrome c

Concanavalin A (ConA), normally a mitogen of T-lymphocytes, was found to be a cell cycle-independent apoptosis-inducing agent in cultured murine macrophage PU5-1.8 cells. This assertion is based on the following observations: (1) ConA increased the number of cells with hypodiploid DNA in a dose depe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Apoptosis (London) 2000-10, Vol.5 (4), p.369-377
Hauptverfasser:	Suen, Y K, Fung, K P, Choy, Y M, Lee, C Y, Chan, C W, Kong, S K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Cell cycle Cell Cycle - drug effects Cell Line Concanavalin A - pharmacology Cytochrome Cytochrome c Group - metabolism Cytochrome c Group - secretion Cytotoxicity Deoxyribonucleic acid DNA DNA - analysis DNA Fragmentation Electrophoresis Electroporation Flow Cytometry Fluorescent Dyes - metabolism Lymphocytes Macrophages - drug effects Macrophages - physiology Methylmannosides - pharmacology Mice Mitochondria Mitochondria - drug effects Mitochondria - enzymology Mitochondria - metabolism Organic Chemicals
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!