Wall thickness and constrictive responses of the caudal artery in rats with renovascular hypertension
In rats with hypertension modeled by the one kidney-one clamp method, constrictory responses of the isolated caudal artery to norepinephrine differed under various perfusion conditions. Vascular reactions in hypertensive rats were more potent at a constant flow rate, and less potent at a constant pr...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2000-08, Vol.130 (8), p.749-751 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Vlasova, M A Borovik, A S Timin, E N Chernyaev, A L Mikhaleva, L M Tarasova, O S Rodionov, I M |
| description | In rats with hypertension modeled by the one kidney-one clamp method, constrictory responses of the isolated caudal artery to norepinephrine differed under various perfusion conditions. Vascular reactions in hypertensive rats were more potent at a constant flow rate, and less potent at a constant pressure compared to those in normotensive rats. Previous experiments demonstrated similar changes in constrictory responses of the caudal artery in spontaneously hypertensive rats. It is assumed that these peculiarities of the vascular reactivity during hypertension are determined by thickening of the smooth muscle layer of the vascular wall. |
| doi_str_mv | 10.1007/BF02766084 |
| format | Article |
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Vascular reactions in hypertensive rats were more potent at a constant flow rate, and less potent at a constant pressure compared to those in normotensive rats. Previous experiments demonstrated similar changes in constrictory responses of the caudal artery in spontaneously hypertensive rats. It is assumed that these peculiarities of the vascular reactivity during hypertension are determined by thickening of the smooth muscle layer of the vascular wall.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/BF02766084</identifier><identifier>PMID: 11177233</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Hypertension ; Hypertension, Renovascular - pathology ; Hypertension, Renovascular - physiopathology ; In Vitro Techniques ; Kidneys ; Male ; Muscle, Smooth, Vascular - pathology ; Norepinephrine ; Norepinephrine - pharmacology ; Perfusion ; Rats ; Rats, Wistar ; Renal Artery - drug effects ; Renal Artery - pathology ; Renal Artery - physiopathology ; Smooth muscle ; Vascular Resistance - drug effects ; Vasoconstriction - drug effects ; Vasoconstriction - physiology</subject><ispartof>Bulletin of experimental biology and medicine, 2000-08, Vol.130 (8), p.749-751</ispartof><rights>Kluwer Academic/Plenum Publishers 2000.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-9121df4e80dea5c5685ebb6b8b91e1e208a95b5d367ef13d9096757e4d8d0b1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11177233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vlasova, M A</creatorcontrib><creatorcontrib>Borovik, A S</creatorcontrib><creatorcontrib>Timin, E N</creatorcontrib><creatorcontrib>Chernyaev, A L</creatorcontrib><creatorcontrib>Mikhaleva, L M</creatorcontrib><creatorcontrib>Tarasova, O S</creatorcontrib><creatorcontrib>Rodionov, I M</creatorcontrib><title>Wall thickness and constrictive responses of the caudal artery in rats with renovascular hypertension</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>In rats with hypertension modeled by the one kidney-one clamp method, constrictory responses of the isolated caudal artery to norepinephrine differed under various perfusion conditions. 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| subjects | Animals Hypertension Hypertension, Renovascular - pathology Hypertension, Renovascular - physiopathology In Vitro Techniques Kidneys Male Muscle, Smooth, Vascular - pathology Norepinephrine Norepinephrine - pharmacology Perfusion Rats Rats, Wistar Renal Artery - drug effects Renal Artery - pathology Renal Artery - physiopathology Smooth muscle Vascular Resistance - drug effects Vasoconstriction - drug effects Vasoconstriction - physiology |
| title | Wall thickness and constrictive responses of the caudal artery in rats with renovascular hypertension |
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