Deletion of the 19kDa antigen does not alter the protective efficacy of BCG
Expression of the Mycobacterium tuberculosis 19kDa lipoprotein in saprophytic mycobacteria has been found to reduce their ability to prime a protective response to subsequent virulent challenge in the mouse model. The present study was designed to test whether 19kDa expression has an analogous detri...
Gespeichert in:
| Veröffentlicht in: | Tubercle and lung disease 2000-01, Vol.80 (6), p.243-247 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 247 |
|---|---|
| container_issue | 6 |
| container_start_page | 243 |
| container_title | Tubercle and lung disease |
| container_volume | 80 |
| creator | Yeremeev, V.V. Stewart, G.R. Neyrolles, O. Skrabal, K. Avdienko, V.G. Apt, A.S. Young, D.B. |
| description | Expression of the Mycobacterium tuberculosis 19kDa lipoprotein in saprophytic mycobacteria has been found to reduce their ability to prime a protective response to subsequent virulent challenge in the mouse model. The present study was designed to test whether 19kDa expression has an analogous detrimental effect on the efficacy of BCG vaccination. In contrast to the results in saprophytes, neither overexpression of the 19kDa antigen, nor deletion of the endogenous 19kDa gene altered the ability of BCG to protect against M. tuberculosis challenge in a mouse model. |
| doi_str_mv | 10.1054/tuld.2000.0252 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72559872</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0962847900902521</els_id><sourcerecordid>17860072</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-df31ea16a7d0fdc205a8950e861d71369ce30e3726abb83a6c37bf71b9b2c8483</originalsourceid><addsrcrecordid>eNqFkDtPwzAURi0EoqWwMqJMbCl-xI-M0EJBVGIBic1y7BswpAnETqX-e5K2EhNiusv5jq4OQucETwnm2VXsKjelGOMpppweoDHhjKaU5K-HaIxzQVOVyXyETkL46CmaiewYjQghgkrBx-hxDhVE39RJUybxHRKSf85NYuro36BOXAMhqZuYmCpCuwW-2iaCjX4NCZSlt8Zuhu3NbHGKjkpTBTjb3wl6ubt9nt2ny6fFw-x6mVomSUxdyQgYIox0uHSWYm5UzjEoQZwkTOQWGAYmqTBFoZgR_awoJSnyglqVKTZBlztv_8p3ByHqlQ8WqsrU0HRBS8p5riT9FyRSCYy34HQH2rYJoYVSf7V-ZdqNJlgPnfXQWQ-d9dC5H1zszV2xAveL78P2gNoB0IdYe2h1sB5qC863fT3tGv-X-wfqnIrv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17860072</pqid></control><display><type>article</type><title>Deletion of the 19kDa antigen does not alter the protective efficacy of BCG</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Yeremeev, V.V. ; Stewart, G.R. ; Neyrolles, O. ; Skrabal, K. ; Avdienko, V.G. ; Apt, A.S. ; Young, D.B.</creator><creatorcontrib>Yeremeev, V.V. ; Stewart, G.R. ; Neyrolles, O. ; Skrabal, K. ; Avdienko, V.G. ; Apt, A.S. ; Young, D.B.</creatorcontrib><description>Expression of the Mycobacterium tuberculosis 19kDa lipoprotein in saprophytic mycobacteria has been found to reduce their ability to prime a protective response to subsequent virulent challenge in the mouse model. The present study was designed to test whether 19kDa expression has an analogous detrimental effect on the efficacy of BCG vaccination. In contrast to the results in saprophytes, neither overexpression of the 19kDa antigen, nor deletion of the endogenous 19kDa gene altered the ability of BCG to protect against M. tuberculosis challenge in a mouse model.</description><identifier>ISSN: 0962-8479</identifier><identifier>EISSN: 1532-219X</identifier><identifier>DOI: 10.1054/tuld.2000.0252</identifier><identifier>PMID: 11162765</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>19kDa antigen ; Animals ; Antigens, Bacterial - genetics ; Antigens, Bacterial - metabolism ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; BCG ; BCG Vaccine - genetics ; Blotting, Western ; Colony Count, Microbial ; Electrophoresis, Agar Gel ; Electroporation ; Female ; Gene Deletion ; Gene Expression ; lipoproteins ; Mice ; Mice, Inbred C57BL ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - immunology ; Polymerase Chain Reaction ; Treatment Outcome ; Tuberculosis - prevention & control</subject><ispartof>Tubercle and lung disease, 2000-01, Vol.80 (6), p.243-247</ispartof><rights>2000 Harcourt Publishers Ltd</rights><rights>Copyright 2000 Harcourt Publishers Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-df31ea16a7d0fdc205a8950e861d71369ce30e3726abb83a6c37bf71b9b2c8483</citedby><cites>FETCH-LOGICAL-c371t-df31ea16a7d0fdc205a8950e861d71369ce30e3726abb83a6c37bf71b9b2c8483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11162765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeremeev, V.V.</creatorcontrib><creatorcontrib>Stewart, G.R.</creatorcontrib><creatorcontrib>Neyrolles, O.</creatorcontrib><creatorcontrib>Skrabal, K.</creatorcontrib><creatorcontrib>Avdienko, V.G.</creatorcontrib><creatorcontrib>Apt, A.S.</creatorcontrib><creatorcontrib>Young, D.B.</creatorcontrib><title>Deletion of the 19kDa antigen does not alter the protective efficacy of BCG</title><title>Tubercle and lung disease</title><addtitle>Tuber Lung Dis</addtitle><description>Expression of the Mycobacterium tuberculosis 19kDa lipoprotein in saprophytic mycobacteria has been found to reduce their ability to prime a protective response to subsequent virulent challenge in the mouse model. The present study was designed to test whether 19kDa expression has an analogous detrimental effect on the efficacy of BCG vaccination. In contrast to the results in saprophytes, neither overexpression of the 19kDa antigen, nor deletion of the endogenous 19kDa gene altered the ability of BCG to protect against M. tuberculosis challenge in a mouse model.</description><subject>19kDa antigen</subject><subject>Animals</subject><subject>Antigens, Bacterial - genetics</subject><subject>Antigens, Bacterial - metabolism</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>BCG</subject><subject>BCG Vaccine - genetics</subject><subject>Blotting, Western</subject><subject>Colony Count, Microbial</subject><subject>Electrophoresis, Agar Gel</subject><subject>Electroporation</subject><subject>Female</subject><subject>Gene Deletion</subject><subject>Gene Expression</subject><subject>lipoproteins</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - immunology</subject><subject>Polymerase Chain Reaction</subject><subject>Treatment Outcome</subject><subject>Tuberculosis - prevention & control</subject><issn>0962-8479</issn><issn>1532-219X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAURi0EoqWwMqJMbCl-xI-M0EJBVGIBic1y7BswpAnETqX-e5K2EhNiusv5jq4OQucETwnm2VXsKjelGOMpppweoDHhjKaU5K-HaIxzQVOVyXyETkL46CmaiewYjQghgkrBx-hxDhVE39RJUybxHRKSf85NYuro36BOXAMhqZuYmCpCuwW-2iaCjX4NCZSlt8Zuhu3NbHGKjkpTBTjb3wl6ubt9nt2ny6fFw-x6mVomSUxdyQgYIox0uHSWYm5UzjEoQZwkTOQWGAYmqTBFoZgR_awoJSnyglqVKTZBlztv_8p3ByHqlQ8WqsrU0HRBS8p5riT9FyRSCYy34HQH2rYJoYVSf7V-ZdqNJlgPnfXQWQ-d9dC5H1zszV2xAveL78P2gNoB0IdYe2h1sB5qC863fT3tGv-X-wfqnIrv</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Yeremeev, V.V.</creator><creator>Stewart, G.R.</creator><creator>Neyrolles, O.</creator><creator>Skrabal, K.</creator><creator>Avdienko, V.G.</creator><creator>Apt, A.S.</creator><creator>Young, D.B.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>Deletion of the 19kDa antigen does not alter the protective efficacy of BCG</title><author>Yeremeev, V.V. ; Stewart, G.R. ; Neyrolles, O. ; Skrabal, K. ; Avdienko, V.G. ; Apt, A.S. ; Young, D.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-df31ea16a7d0fdc205a8950e861d71369ce30e3726abb83a6c37bf71b9b2c8483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>19kDa antigen</topic><topic>Animals</topic><topic>Antigens, Bacterial - genetics</topic><topic>Antigens, Bacterial - metabolism</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>BCG</topic><topic>BCG Vaccine - genetics</topic><topic>Blotting, Western</topic><topic>Colony Count, Microbial</topic><topic>Electrophoresis, Agar Gel</topic><topic>Electroporation</topic><topic>Female</topic><topic>Gene Deletion</topic><topic>Gene Expression</topic><topic>lipoproteins</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - immunology</topic><topic>Polymerase Chain Reaction</topic><topic>Treatment Outcome</topic><topic>Tuberculosis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeremeev, V.V.</creatorcontrib><creatorcontrib>Stewart, G.R.</creatorcontrib><creatorcontrib>Neyrolles, O.</creatorcontrib><creatorcontrib>Skrabal, K.</creatorcontrib><creatorcontrib>Avdienko, V.G.</creatorcontrib><creatorcontrib>Apt, A.S.</creatorcontrib><creatorcontrib>Young, D.B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Tubercle and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeremeev, V.V.</au><au>Stewart, G.R.</au><au>Neyrolles, O.</au><au>Skrabal, K.</au><au>Avdienko, V.G.</au><au>Apt, A.S.</au><au>Young, D.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deletion of the 19kDa antigen does not alter the protective efficacy of BCG</atitle><jtitle>Tubercle and lung disease</jtitle><addtitle>Tuber Lung Dis</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>80</volume><issue>6</issue><spage>243</spage><epage>247</epage><pages>243-247</pages><issn>0962-8479</issn><eissn>1532-219X</eissn><abstract>Expression of the Mycobacterium tuberculosis 19kDa lipoprotein in saprophytic mycobacteria has been found to reduce their ability to prime a protective response to subsequent virulent challenge in the mouse model. The present study was designed to test whether 19kDa expression has an analogous detrimental effect on the efficacy of BCG vaccination. In contrast to the results in saprophytes, neither overexpression of the 19kDa antigen, nor deletion of the endogenous 19kDa gene altered the ability of BCG to protect against M. tuberculosis challenge in a mouse model.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>11162765</pmid><doi>10.1054/tuld.2000.0252</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0962-8479 |
| ispartof | Tubercle and lung disease, 2000-01, Vol.80 (6), p.243-247 |
| issn | 0962-8479 1532-219X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72559872 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 19kDa antigen Animals Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism BCG BCG Vaccine - genetics Blotting, Western Colony Count, Microbial Electrophoresis, Agar Gel Electroporation Female Gene Deletion Gene Expression lipoproteins Mice Mice, Inbred C57BL Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Polymerase Chain Reaction Treatment Outcome Tuberculosis - prevention & control |
| title | Deletion of the 19kDa antigen does not alter the protective efficacy of BCG |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T21%3A37%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deletion%20of%20the%2019kDa%20antigen%20does%20not%20alter%20the%20protective%20efficacy%20of%20BCG&rft.jtitle=Tubercle%20and%20lung%20disease&rft.au=Yeremeev,%20V.V.&rft.date=2000-01-01&rft.volume=80&rft.issue=6&rft.spage=243&rft.epage=247&rft.pages=243-247&rft.issn=0962-8479&rft.eissn=1532-219X&rft_id=info:doi/10.1054/tuld.2000.0252&rft_dat=%3Cproquest_cross%3E17860072%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17860072&rft_id=info:pmid/11162765&rft_els_id=S0962847900902521&rfr_iscdi=true |