Effect of calcium and calcium antagonists on 45Ca influx and cellular growth of human prostatic tumor cells

Calcium and calmodulin play significant roles in DNA synthesis and cell proliferation. In this work the effects of verapamil, trifluoperazine, and tamoxifen on 45Ca uptake and cell growth in human prostatic tumor cells (DU 145) and human fibroblast cells (1 BR) were studied. Although the maximum pro...

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Veröffentlicht in:	The Prostate 1991, Vol.19 (4), p.299-311
Hauptverfasser:	Batra, Satish, Popper, Lars D., Hartley-Asp, Beryl
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium - metabolism Calcium - pharmacology Calcium Channel Blockers - pharmacology calcium channels Calcium Channels - drug effects Calcium Radioisotopes Calmodulin - antagonists & inhibitors Cell Division - drug effects cell proliferation Extracellular Space - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Humans Kinetics Lanthanum - pharmacology Male Medical sciences Pharmacology. Drug treatments Potassium - pharmacology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology tamoxifen Tamoxifen - pharmacology Trifluoperazine - pharmacology Tumor Cells, Cultured Urinary system verapamil Verapamil - pharmacology
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