Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment
Previous reports have shown elevated plasma total homocysteine (tHcy) levels in elderly person with impaired cognition. To study the association between cognitive status and plasma tHcy levels in centenarians. Cross-sectional survey. Centenarians living in two northern Italian provinces. Thirteen co...
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| Veröffentlicht in: | Mechanisms of ageing and development 2000-12, Vol.121 (1-3), p.251-261 |
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| creator | RAVAGLIA, Giovanni FORTI, Paola CAVALLI, Giancarlo MAIOLI, Fabiola VETTORI, Chiara GROSSI, Gabriele BARGOSSI, Alberto Mario CALDARERA, Marcello FRANCESCHI, Claudio FACCHINI, Andrea MARIANI, Erminia |
| description | Previous reports have shown elevated plasma total homocysteine (tHcy) levels in elderly person with impaired cognition.
To study the association between cognitive status and plasma tHcy levels in centenarians.
Cross-sectional survey.
Centenarians living in two northern Italian provinces.
Thirteen cognitively normal centenarians, ten cognitively impaired not-demented centenarians, and 34 demented centenarians with a clinical diagnosis of Alzheimer's disease (AD).
Blood levels of homocysteine's biological determinants vitamin B12, folate, and vitamin B6.
Elevated plasma tHcy levels (>17 micromol/l) were common in the general population (77% of normal centenarians, 100% of cognitively impaired not-demented centenarians, 82% of AD centenarians). Demented centenarians had the lowest folate serum levels. Low or borderline vitamin B12 serum levels ( |
| format | Article |
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To study the association between cognitive status and plasma tHcy levels in centenarians.
Cross-sectional survey.
Centenarians living in two northern Italian provinces.
Thirteen cognitively normal centenarians, ten cognitively impaired not-demented centenarians, and 34 demented centenarians with a clinical diagnosis of Alzheimer's disease (AD).
Blood levels of homocysteine's biological determinants vitamin B12, folate, and vitamin B6.
Elevated plasma tHcy levels (>17 micromol/l) were common in the general population (77% of normal centenarians, 100% of cognitively impaired not-demented centenarians, 82% of AD centenarians). Demented centenarians had the lowest folate serum levels. Low or borderline vitamin B12 serum levels (<221 pmol/l) and low vitamin B6 plasma levels (<11.7 nmol/l) were found in 33 and 66% of all centenarians independently of cognitive status. Among demented centenarians only plasma tHcy correlated inversely with both serum vitamin B12 and folate. No significant difference was found for plasma tHcy levels among the three diagnostic groups, even after adjusting for B vitamin levels.
Hyperhomocysteinemia is very common among centenarians, probably due to vitamin deficiencies, but does not seem to be associated with cognitive impairment.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>PMID: 11164478</identifier><identifier>CODEN: MAGDA3</identifier><language>eng</language><publisher>Shannon: Elsevier Science</publisher><subject>Aged ; Aged, 80 and over ; Aging - blood ; Alzheimer Disease - blood ; Biological and medical sciences ; Cognition Disorders - blood ; Cross-Sectional Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia - blood ; Dementia, Vascular - blood ; Female ; Folic Acid - blood ; Health Surveys ; Homocysteine - blood ; Humans ; Male ; Medical sciences ; Neurology ; Pyridoxine - blood ; Reference Values ; Vitamin B 12 - blood</subject><ispartof>Mechanisms of ageing and development, 2000-12, Vol.121 (1-3), p.251-261</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=880883$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11164478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RAVAGLIA, Giovanni</creatorcontrib><creatorcontrib>FORTI, Paola</creatorcontrib><creatorcontrib>CAVALLI, Giancarlo</creatorcontrib><creatorcontrib>MAIOLI, Fabiola</creatorcontrib><creatorcontrib>VETTORI, Chiara</creatorcontrib><creatorcontrib>GROSSI, Gabriele</creatorcontrib><creatorcontrib>BARGOSSI, Alberto Mario</creatorcontrib><creatorcontrib>CALDARERA, Marcello</creatorcontrib><creatorcontrib>FRANCESCHI, Claudio</creatorcontrib><creatorcontrib>FACCHINI, Andrea</creatorcontrib><creatorcontrib>MARIANI, Erminia</creatorcontrib><title>Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>Previous reports have shown elevated plasma total homocysteine (tHcy) levels in elderly person with impaired cognition.
To study the association between cognitive status and plasma tHcy levels in centenarians.
Cross-sectional survey.
Centenarians living in two northern Italian provinces.
Thirteen cognitively normal centenarians, ten cognitively impaired not-demented centenarians, and 34 demented centenarians with a clinical diagnosis of Alzheimer's disease (AD).
Blood levels of homocysteine's biological determinants vitamin B12, folate, and vitamin B6.
Elevated plasma tHcy levels (>17 micromol/l) were common in the general population (77% of normal centenarians, 100% of cognitively impaired not-demented centenarians, 82% of AD centenarians). Demented centenarians had the lowest folate serum levels. Low or borderline vitamin B12 serum levels (<221 pmol/l) and low vitamin B6 plasma levels (<11.7 nmol/l) were found in 33 and 66% of all centenarians independently of cognitive status. Among demented centenarians only plasma tHcy correlated inversely with both serum vitamin B12 and folate. No significant difference was found for plasma tHcy levels among the three diagnostic groups, even after adjusting for B vitamin levels.
Hyperhomocysteinemia is very common among centenarians, probably due to vitamin deficiencies, but does not seem to be associated with cognitive impairment.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - blood</subject><subject>Alzheimer Disease - blood</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - blood</subject><subject>Cross-Sectional Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia - blood</subject><subject>Dementia, Vascular - blood</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Health Surveys</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Pyridoxine - blood</subject><subject>Reference Values</subject><subject>Vitamin B 12 - blood</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90E1LxDAQBuAgiruu_gUJCN4KSZMmucqyfsCCFz3XaTJ1I21Sm3Rl_71FV09zmOd9GeaELLnRZaFKrk7JkjGpCyW0XJCLlD4YY1yW6pwsOOdKSm2W5G3T4R4yOjp0kHqgu9hHe0gZfUA677BL1AdqMWQMMHoIicKINMRMIaVo_U_6y-cdtfE9-Oz3SH0_gB_7OXRJzlroEl4d54q83m9e1o_F9vnhaX23LQaudC4Uzmc2ohLcoWxAG-WsE6ZiqpSVA-MapaRrdausZkJaXgqphXVQiQqgAbEit7-9wxg_J0y57n2y2HUQME6p1mVVGanKGV4f4dT06Oph9D2Mh_rvJzO4OQJIFrp2hGB9-nfGMGOE-Abet2zN</recordid><startdate>20001220</startdate><enddate>20001220</enddate><creator>RAVAGLIA, Giovanni</creator><creator>FORTI, Paola</creator><creator>CAVALLI, Giancarlo</creator><creator>MAIOLI, Fabiola</creator><creator>VETTORI, Chiara</creator><creator>GROSSI, Gabriele</creator><creator>BARGOSSI, Alberto Mario</creator><creator>CALDARERA, Marcello</creator><creator>FRANCESCHI, Claudio</creator><creator>FACCHINI, Andrea</creator><creator>MARIANI, Erminia</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20001220</creationdate><title>Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment</title><author>RAVAGLIA, Giovanni ; FORTI, Paola ; CAVALLI, Giancarlo ; MAIOLI, Fabiola ; VETTORI, Chiara ; GROSSI, Gabriele ; BARGOSSI, Alberto Mario ; CALDARERA, Marcello ; FRANCESCHI, Claudio ; FACCHINI, Andrea ; MARIANI, Erminia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p167t-6e374b3531de4ba786dcd38506245da8db664df7f6c7034c123473cda535aaba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - blood</topic><topic>Alzheimer Disease - blood</topic><topic>Biological and medical sciences</topic><topic>Cognition Disorders - blood</topic><topic>Cross-Sectional Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia - blood</topic><topic>Dementia, Vascular - blood</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>Health Surveys</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Pyridoxine - blood</topic><topic>Reference Values</topic><topic>Vitamin B 12 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RAVAGLIA, Giovanni</creatorcontrib><creatorcontrib>FORTI, Paola</creatorcontrib><creatorcontrib>CAVALLI, Giancarlo</creatorcontrib><creatorcontrib>MAIOLI, Fabiola</creatorcontrib><creatorcontrib>VETTORI, Chiara</creatorcontrib><creatorcontrib>GROSSI, Gabriele</creatorcontrib><creatorcontrib>BARGOSSI, Alberto Mario</creatorcontrib><creatorcontrib>CALDARERA, Marcello</creatorcontrib><creatorcontrib>FRANCESCHI, Claudio</creatorcontrib><creatorcontrib>FACCHINI, Andrea</creatorcontrib><creatorcontrib>MARIANI, Erminia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RAVAGLIA, Giovanni</au><au>FORTI, Paola</au><au>CAVALLI, Giancarlo</au><au>MAIOLI, Fabiola</au><au>VETTORI, Chiara</au><au>GROSSI, Gabriele</au><au>BARGOSSI, Alberto Mario</au><au>CALDARERA, Marcello</au><au>FRANCESCHI, Claudio</au><au>FACCHINI, Andrea</au><au>MARIANI, Erminia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>2000-12-20</date><risdate>2000</risdate><volume>121</volume><issue>1-3</issue><spage>251</spage><epage>261</epage><pages>251-261</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><coden>MAGDA3</coden><abstract>Previous reports have shown elevated plasma total homocysteine (tHcy) levels in elderly person with impaired cognition.
To study the association between cognitive status and plasma tHcy levels in centenarians.
Cross-sectional survey.
Centenarians living in two northern Italian provinces.
Thirteen cognitively normal centenarians, ten cognitively impaired not-demented centenarians, and 34 demented centenarians with a clinical diagnosis of Alzheimer's disease (AD).
Blood levels of homocysteine's biological determinants vitamin B12, folate, and vitamin B6.
Elevated plasma tHcy levels (>17 micromol/l) were common in the general population (77% of normal centenarians, 100% of cognitively impaired not-demented centenarians, 82% of AD centenarians). Demented centenarians had the lowest folate serum levels. Low or borderline vitamin B12 serum levels (<221 pmol/l) and low vitamin B6 plasma levels (<11.7 nmol/l) were found in 33 and 66% of all centenarians independently of cognitive status. Among demented centenarians only plasma tHcy correlated inversely with both serum vitamin B12 and folate. No significant difference was found for plasma tHcy levels among the three diagnostic groups, even after adjusting for B vitamin levels.
Hyperhomocysteinemia is very common among centenarians, probably due to vitamin deficiencies, but does not seem to be associated with cognitive impairment.</abstract><cop>Shannon</cop><pub>Elsevier Science</pub><pmid>11164478</pmid><tpages>11</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Aging - blood Alzheimer Disease - blood Biological and medical sciences Cognition Disorders - blood Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - blood Dementia, Vascular - blood Female Folic Acid - blood Health Surveys Homocysteine - blood Humans Male Medical sciences Neurology Pyridoxine - blood Reference Values Vitamin B 12 - blood |
| title | Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment |
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