DNA aneuploidy in invasive carcinoma of the uterine cervix
Forty cases of squamous cell carcinoma and twenty cases of adenocarcinoma of the cervix were subjected to DNA ploidy analysis to find out the frequency of aneuploid DNA pattern in different types of invasive carcinoma of the uterine cervix and their possible correlation with the clinical stage and a...
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Veröffentlicht in: | Indian journal of pathology & microbiology 2000-07, Vol.43 (3), p.265-269 |
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description | Forty cases of squamous cell carcinoma and twenty cases of adenocarcinoma of the cervix were subjected to DNA ploidy analysis to find out the frequency of aneuploid DNA pattern in different types of invasive carcinoma of the uterine cervix and their possible correlation with the clinical stage and age of the patients. From the DNA analysis an increasing trend of DNA aneuploidy was observed from well differentiated (63.6%) to moderately differentiated (70.8%) to poorly differentiated squamous cell carcinoma (83.3%). However, 85% adenocarcinomas of endocervix showed aneuploid DNA pattern. It indicates that aneuploidy increases with tumour dedifferentiation and further confirms the importance of DNA ploidy as a high risk indicator. |
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From the DNA analysis an increasing trend of DNA aneuploidy was observed from well differentiated (63.6%) to moderately differentiated (70.8%) to poorly differentiated squamous cell carcinoma (83.3%). However, 85% adenocarcinomas of endocervix showed aneuploid DNA pattern. 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From the DNA analysis an increasing trend of DNA aneuploidy was observed from well differentiated (63.6%) to moderately differentiated (70.8%) to poorly differentiated squamous cell carcinoma (83.3%). However, 85% adenocarcinomas of endocervix showed aneuploid DNA pattern. It indicates that aneuploidy increases with tumour dedifferentiation and further confirms the importance of DNA ploidy as a high risk indicator.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aneuploidy</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cervix Uteri - pathology</subject><subject>DNA, Neoplasm - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0377-4929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j0tLAzEcxHNQbG39CpKTt4U8_9n1VuoTil7seclrMbIvk81iv70LVhiYw_wYZi7QmnClClGxaoWuU_oiBAST_AqtKGW0BEXW6P7hbYd17_PYDsGdcOgXzTqF2WOrow390Gk8NHj69DhPPoZ-CXycw88WXTa6Tf7m7Bt0fHr82L8Uh_fn1_3uUIyUsamwDpQCVlJwAhy3BiTX0ijXgDWCgKuo4wY0lMKYxgNRTBBlmbVUyYqXfIPu_nrHOHxnn6a6C8n6tl1mDznViklZclIt4O0ZzKbzrh5j6HQ81f9v-S8M507g</recordid><startdate>200007</startdate><enddate>200007</enddate><creator>Kashyap, V</creator><creator>Bhambhani, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200007</creationdate><title>DNA aneuploidy in invasive carcinoma of the uterine cervix</title><author>Kashyap, V ; Bhambhani, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-cd67762816d46d3cb653a5b7df6cb406d91d3b6a684bbfe6072407c2cc1759383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aneuploidy</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cervix Uteri - pathology</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashyap, V</creatorcontrib><creatorcontrib>Bhambhani, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of pathology & microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kashyap, V</au><au>Bhambhani, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA aneuploidy in invasive carcinoma of the uterine cervix</atitle><jtitle>Indian journal of pathology & microbiology</jtitle><addtitle>Indian J Pathol Microbiol</addtitle><date>2000-07</date><risdate>2000</risdate><volume>43</volume><issue>3</issue><spage>265</spage><epage>269</epage><pages>265-269</pages><issn>0377-4929</issn><abstract>Forty cases of squamous cell carcinoma and twenty cases of adenocarcinoma of the cervix were subjected to DNA ploidy analysis to find out the frequency of aneuploid DNA pattern in different types of invasive carcinoma of the uterine cervix and their possible correlation with the clinical stage and age of the patients. 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subjects | Adenocarcinoma - genetics Adenocarcinoma - pathology Adult Aged Aneuploidy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cervix Uteri - pathology DNA, Neoplasm - analysis Female Humans Middle Aged Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology |
title | DNA aneuploidy in invasive carcinoma of the uterine cervix |
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