DNA aneuploidy in invasive carcinoma of the uterine cervix

Forty cases of squamous cell carcinoma and twenty cases of adenocarcinoma of the cervix were subjected to DNA ploidy analysis to find out the frequency of aneuploid DNA pattern in different types of invasive carcinoma of the uterine cervix and their possible correlation with the clinical stage and a...

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Veröffentlicht in:Indian journal of pathology & microbiology 2000-07, Vol.43 (3), p.265-269
Hauptverfasser: Kashyap, V, Bhambhani, S
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description Forty cases of squamous cell carcinoma and twenty cases of adenocarcinoma of the cervix were subjected to DNA ploidy analysis to find out the frequency of aneuploid DNA pattern in different types of invasive carcinoma of the uterine cervix and their possible correlation with the clinical stage and age of the patients. From the DNA analysis an increasing trend of DNA aneuploidy was observed from well differentiated (63.6%) to moderately differentiated (70.8%) to poorly differentiated squamous cell carcinoma (83.3%). However, 85% adenocarcinomas of endocervix showed aneuploid DNA pattern. It indicates that aneuploidy increases with tumour dedifferentiation and further confirms the importance of DNA ploidy as a high risk indicator.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adult
Aged
Aneuploidy
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Cervix Uteri - pathology
DNA, Neoplasm - analysis
Female
Humans
Middle Aged
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - pathology
title DNA aneuploidy in invasive carcinoma of the uterine cervix
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