Prevalence of HIV infection in seronegative high-risk individuals examined by virus isolation and PCR
HIV seronegative individuals with high-risk behavior were tested for HIV infection by sensitive virus isolation techniques using T4 lymphocytes and monocyte/macrophages, and by detection of proviral DNA using PCR with three different sets of nested primers. No evidence of HIV infection was found amo...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1988) 1991, Vol.4 (11), p.1107-1111 |
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| container_issue | 11 |
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| container_title | Journal of acquired immune deficiency syndromes (1988) |
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| creator | NIELSEN, C TEGLBJÆRG, L. S PEDERSEN, C LUNDGREN, J. D NIELSEN, C. M VESTERGAARD, B. F |
| description | HIV seronegative individuals with high-risk behavior were tested for HIV infection by sensitive virus isolation techniques using T4 lymphocytes and monocyte/macrophages, and by detection of proviral DNA using PCR with three different sets of nested primers. No evidence of HIV infection was found among the 31 seronegative high-risk subjects, either by virus isolation of by PCR (97.5% confidence limits, 0-11). Our results indicate that ongoing HIV infection in seronegative persons at high risk of infection is a rare event. |
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S ; PEDERSEN, C ; LUNDGREN, J. D ; NIELSEN, C. M ; VESTERGAARD, B. F</creator><creatorcontrib>NIELSEN, C ; TEGLBJÆRG, L. S ; PEDERSEN, C ; LUNDGREN, J. D ; NIELSEN, C. M ; VESTERGAARD, B. F</creatorcontrib><description>HIV seronegative individuals with high-risk behavior were tested for HIV infection by sensitive virus isolation techniques using T4 lymphocytes and monocyte/macrophages, and by detection of proviral DNA using PCR with three different sets of nested primers. No evidence of HIV infection was found among the 31 seronegative high-risk subjects, either by virus isolation of by PCR (97.5% confidence limits, 0-11). Our results indicate that ongoing HIV infection in seronegative persons at high risk of infection is a rare event.</description><identifier>ISSN: 0894-9255</identifier><identifier>EISSN: 2331-2289</identifier><identifier>PMID: 1684386</identifier><language>eng</language><publisher>New York, NY: Raven Press</publisher><subject>Acquired Immunodeficiency Syndrome - diagnosis ; AIDS/HIV ; Base Sequence ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - chemistry ; Female ; HIV Seropositivity - diagnosis ; HIV Seroprevalence ; HIV-1 - isolation & purification ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Male ; Medical sciences ; Molecular Sequence Data ; Polymerase Chain Reaction ; Risk Factors</subject><ispartof>Journal of acquired immune deficiency syndromes (1988), 1991, Vol.4 (11), p.1107-1111</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5140707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1684386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NIELSEN, C</creatorcontrib><creatorcontrib>TEGLBJÆRG, L. S</creatorcontrib><creatorcontrib>PEDERSEN, C</creatorcontrib><creatorcontrib>LUNDGREN, J. D</creatorcontrib><creatorcontrib>NIELSEN, C. M</creatorcontrib><creatorcontrib>VESTERGAARD, B. F</creatorcontrib><title>Prevalence of HIV infection in seronegative high-risk individuals examined by virus isolation and PCR</title><title>Journal of acquired immune deficiency syndromes (1988)</title><addtitle>J Acquir Immune Defic Syndr (1988)</addtitle><description>HIV seronegative individuals with high-risk behavior were tested for HIV infection by sensitive virus isolation techniques using T4 lymphocytes and monocyte/macrophages, and by detection of proviral DNA using PCR with three different sets of nested primers. No evidence of HIV infection was found among the 31 seronegative high-risk subjects, either by virus isolation of by PCR (97.5% confidence limits, 0-11). Our results indicate that ongoing HIV infection in seronegative persons at high risk of infection is a rare event.</description><subject>Acquired Immunodeficiency Syndrome - diagnosis</subject><subject>AIDS/HIV</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - chemistry</subject><subject>Female</subject><subject>HIV Seropositivity - diagnosis</subject><subject>HIV Seroprevalence</subject><subject>HIV-1 - isolation & purification</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Risk Factors</subject><issn>0894-9255</issn><issn>2331-2289</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUhoMoc05_gpAL8a6QJm0-LmWoGwgOUW9Llpxs0TadSVvcv7do8eq8nOfhvXhP0JwylmeUSnWK5kSqIlO0LM_RRUofhJRSCTZDs5zLgkk-R7CJMOgaggHcOrxav2MfHJjOt2FMOEFsA-x05wfAe7_bZ9Gnz5FYP3jb6zph-NaND2Dx9ogHH_uEfWpr_dugg8Wb5cslOnOjClfTXaC3h_vX5Sp7en5cL--esgNlZZcpyAmjTAC3ijMlpWRAiCkY1ZoYyvn4tErQgumcEW2dtdQZ5SQxhEsHbIFu_3oPsf3qIXVV45OButYB2j5VYpxCSMJH8XoS-20DtjpE3-h4rKZdRn4zcZ2Mrl3Uwfj0r5V5QQQR7AeBkmyX</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>NIELSEN, C</creator><creator>TEGLBJÆRG, L. S</creator><creator>PEDERSEN, C</creator><creator>LUNDGREN, J. 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F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of HIV infection in seronegative high-risk individuals examined by virus isolation and PCR</atitle><jtitle>Journal of acquired immune deficiency syndromes (1988)</jtitle><addtitle>J Acquir Immune Defic Syndr (1988)</addtitle><date>1991</date><risdate>1991</risdate><volume>4</volume><issue>11</issue><spage>1107</spage><epage>1111</epage><pages>1107-1111</pages><issn>0894-9255</issn><eissn>2331-2289</eissn><abstract>HIV seronegative individuals with high-risk behavior were tested for HIV infection by sensitive virus isolation techniques using T4 lymphocytes and monocyte/macrophages, and by detection of proviral DNA using PCR with three different sets of nested primers. No evidence of HIV infection was found among the 31 seronegative high-risk subjects, either by virus isolation of by PCR (97.5% confidence limits, 0-11). Our results indicate that ongoing HIV infection in seronegative persons at high risk of infection is a rare event.</abstract><cop>New York, NY</cop><pub>Raven Press</pub><pmid>1684386</pmid><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0894-9255 |
| ispartof | Journal of acquired immune deficiency syndromes (1988), 1991, Vol.4 (11), p.1107-1111 |
| issn | 0894-9255 2331-2289 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72557806 |
| source | Ovid Lippincott Williams and Wilkins Journal Legacy Archive; MEDLINE; EZB Electronic Journals Library; Journals@Ovid Complete |
| subjects | Acquired Immunodeficiency Syndrome - diagnosis AIDS/HIV Base Sequence Biological and medical sciences CD4-Positive T-Lymphocytes - chemistry Female HIV Seropositivity - diagnosis HIV Seroprevalence HIV-1 - isolation & purification Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Male Medical sciences Molecular Sequence Data Polymerase Chain Reaction Risk Factors |
| title | Prevalence of HIV infection in seronegative high-risk individuals examined by virus isolation and PCR |
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