Covariation of GC content and the silent site substitution rate in rodents: implications for methodology and for the evolution of isochores

Many attempts to test selectionist and neutralist models employ estimates of synonymous (Ks) and non-synonymous (Ka) substitution rates of orthologous genes. For example, a stronger Ka-Ks correlation than expected under neutrality has been argued to indicate a role for selection and the absence of a...

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Veröffentlicht in:	Gene 2000-12, Vol.261 (1), p.107-114
Hauptverfasser:	Hurst, L D, Williams, E J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Composition DNA - genetics DNA - metabolism DNA Methylation Evolution, Molecular Genetic Variation Genome isochores Mice Mutation Proteins - genetics Rats Rodentia - genetics
Online-Zugang:	Volltext
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