Autoimmunity to human thyroglobulin: Respective epitopic specificity patterns of anti‐human thyroglobulin autoantibodies in patients with sjögren's syndrome and patients with hashimoto's thyroiditis
We evaluated the epitopic specificity pattern of anti‐human thyroglobulin (anti‐hTg) autoantibodies from patients with primary Sjögren's syndrome (SS). All of the primary SS sera tested contained both IgG and IgM anti‐hTg autoantibodies recognizing at least 1 region on hTg; in 65% of the cases,...
Gespeichert in:
| Veröffentlicht in: | Arthritis and rheumatism 1991-12, Vol.34 (12), p.1585-1593 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1593 |
|---|---|
| container_issue | 12 |
| container_start_page | 1585 |
| container_title | Arthritis and rheumatism |
| container_volume | 34 |
| creator | Bouanani, Majida Bataille, Regis Piechaczyk, Martine Salhi, Sharon Lynn Pau, Bernard Bastide, Madeleine |
| description | We evaluated the epitopic specificity pattern of anti‐human thyroglobulin (anti‐hTg) autoantibodies from patients with primary Sjögren's syndrome (SS). All of the primary SS sera tested contained both IgG and IgM anti‐hTg autoantibodies recognizing at least 1 region on hTg; in 65% of the cases, 3 or more regions were recognized. A strong recognition of region II, as is seen in Hashimoto's thyroiditis, was associated with thyroid disorder in primary SS. These results emphasize the importance of region II in autoimmune thyroid disease. |
| doi_str_mv | 10.1002/art.1780341218 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72551145</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72551145</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2958-b4895ccf0311afb8dc2198d3e72c1df94ca24f44803814eda0e7156f79080d93</originalsourceid><addsrcrecordid>eNqFkc-K1TAUxoMo43V0607ISle95qStbd1dBv_BgDDcfUmT0-kZ2qQmqUN3PoJPMy8wK1_DJzHXOzAigquQ833f75B8jD0HsQUh5Gvl4xaqWuQFSKgfsA2UsskE5PCQbYQQRZaXDTxmT0K4SleZl_kJO4FKiqasN-zHbomOpmmxFFceHR-WSVkeh9W7y9F1y0j2Lb_AMKOO9BU5zhTdTJofJtSTPuRmFSN6G7jrubKRfn77_g8OV2nXQe6cIQw8TVKQ0MbArykOPFzd3lx6tK8CD6s13k2YcOYv16DCQJOLLtl-88lQpPCUPerVGPDZ3XnK9u_f7c8-ZuefP3w6251nWqYXZ11RN6XWvcgBVN_VRktoapNjJTWYvim0kkVfFOlHayjQKIEVlG_6qhG1ME1-yl4esbN3XxYMsZ0oaBxHZdEtoa1kWQIUZTJuj0btXQge-3b2NCm_tiDaQ3Vtqq69ry4FXtyRl25Cc28_dpX05qhf04jrf2jt7mL_B_sX36CuxA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72551145</pqid></control><display><type>article</type><title>Autoimmunity to human thyroglobulin: Respective epitopic specificity patterns of anti‐human thyroglobulin autoantibodies in patients with sjögren's syndrome and patients with hashimoto's thyroiditis</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Bouanani, Majida ; Bataille, Regis ; Piechaczyk, Martine ; Salhi, Sharon Lynn ; Pau, Bernard ; Bastide, Madeleine</creator><creatorcontrib>Bouanani, Majida ; Bataille, Regis ; Piechaczyk, Martine ; Salhi, Sharon Lynn ; Pau, Bernard ; Bastide, Madeleine</creatorcontrib><description>We evaluated the epitopic specificity pattern of anti‐human thyroglobulin (anti‐hTg) autoantibodies from patients with primary Sjögren's syndrome (SS). All of the primary SS sera tested contained both IgG and IgM anti‐hTg autoantibodies recognizing at least 1 region on hTg; in 65% of the cases, 3 or more regions were recognized. A strong recognition of region II, as is seen in Hashimoto's thyroiditis, was associated with thyroid disorder in primary SS. These results emphasize the importance of region II in autoimmune thyroid disease.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780341218</identifier><identifier>PMID: 1720958</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Antibodies, Monoclonal ; Antibody Specificity ; Autoantibodies - immunology ; Autoimmunity ; Enzyme-Linked Immunosorbent Assay ; Epitopes - immunology ; Female ; Humans ; Immunoglobulin A - analysis ; Immunoglobulin G - analysis ; Male ; Middle Aged ; Sjogren's Syndrome - blood ; Sjogren's Syndrome - immunology ; Thyroglobulin - immunology ; Thyroiditis, Autoimmune - blood ; Thyroiditis, Autoimmune - immunology</subject><ispartof>Arthritis and rheumatism, 1991-12, Vol.34 (12), p.1585-1593</ispartof><rights>Copyright © 1991 American College of Rheumatology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2958-b4895ccf0311afb8dc2198d3e72c1df94ca24f44803814eda0e7156f79080d93</citedby><cites>FETCH-LOGICAL-c2958-b4895ccf0311afb8dc2198d3e72c1df94ca24f44803814eda0e7156f79080d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.1780341218$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.1780341218$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1720958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouanani, Majida</creatorcontrib><creatorcontrib>Bataille, Regis</creatorcontrib><creatorcontrib>Piechaczyk, Martine</creatorcontrib><creatorcontrib>Salhi, Sharon Lynn</creatorcontrib><creatorcontrib>Pau, Bernard</creatorcontrib><creatorcontrib>Bastide, Madeleine</creatorcontrib><title>Autoimmunity to human thyroglobulin: Respective epitopic specificity patterns of anti‐human thyroglobulin autoantibodies in patients with sjögren's syndrome and patients with hashimoto's thyroiditis</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>We evaluated the epitopic specificity pattern of anti‐human thyroglobulin (anti‐hTg) autoantibodies from patients with primary Sjögren's syndrome (SS). All of the primary SS sera tested contained both IgG and IgM anti‐hTg autoantibodies recognizing at least 1 region on hTg; in 65% of the cases, 3 or more regions were recognized. A strong recognition of region II, as is seen in Hashimoto's thyroiditis, was associated with thyroid disorder in primary SS. These results emphasize the importance of region II in autoimmune thyroid disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Monoclonal</subject><subject>Antibody Specificity</subject><subject>Autoantibodies - immunology</subject><subject>Autoimmunity</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epitopes - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin A - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Sjogren's Syndrome - blood</subject><subject>Sjogren's Syndrome - immunology</subject><subject>Thyroglobulin - immunology</subject><subject>Thyroiditis, Autoimmune - blood</subject><subject>Thyroiditis, Autoimmune - immunology</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-K1TAUxoMo43V0607ISle95qStbd1dBv_BgDDcfUmT0-kZ2qQmqUN3PoJPMy8wK1_DJzHXOzAigquQ833f75B8jD0HsQUh5Gvl4xaqWuQFSKgfsA2UsskE5PCQbYQQRZaXDTxmT0K4SleZl_kJO4FKiqasN-zHbomOpmmxFFceHR-WSVkeh9W7y9F1y0j2Lb_AMKOO9BU5zhTdTJofJtSTPuRmFSN6G7jrubKRfn77_g8OV2nXQe6cIQw8TVKQ0MbArykOPFzd3lx6tK8CD6s13k2YcOYv16DCQJOLLtl-88lQpPCUPerVGPDZ3XnK9u_f7c8-ZuefP3w6251nWqYXZ11RN6XWvcgBVN_VRktoapNjJTWYvim0kkVfFOlHayjQKIEVlG_6qhG1ME1-yl4esbN3XxYMsZ0oaBxHZdEtoa1kWQIUZTJuj0btXQge-3b2NCm_tiDaQ3Vtqq69ry4FXtyRl25Cc28_dpX05qhf04jrf2jt7mL_B_sX36CuxA</recordid><startdate>199112</startdate><enddate>199112</enddate><creator>Bouanani, Majida</creator><creator>Bataille, Regis</creator><creator>Piechaczyk, Martine</creator><creator>Salhi, Sharon Lynn</creator><creator>Pau, Bernard</creator><creator>Bastide, Madeleine</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199112</creationdate><title>Autoimmunity to human thyroglobulin: Respective epitopic specificity patterns of anti‐human thyroglobulin autoantibodies in patients with sjögren's syndrome and patients with hashimoto's thyroiditis</title><author>Bouanani, Majida ; Bataille, Regis ; Piechaczyk, Martine ; Salhi, Sharon Lynn ; Pau, Bernard ; Bastide, Madeleine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2958-b4895ccf0311afb8dc2198d3e72c1df94ca24f44803814eda0e7156f79080d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Monoclonal</topic><topic>Antibody Specificity</topic><topic>Autoantibodies - immunology</topic><topic>Autoimmunity</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epitopes - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin A - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Sjogren's Syndrome - blood</topic><topic>Sjogren's Syndrome - immunology</topic><topic>Thyroglobulin - immunology</topic><topic>Thyroiditis, Autoimmune - blood</topic><topic>Thyroiditis, Autoimmune - immunology</topic><toplevel>online_resources</toplevel><creatorcontrib>Bouanani, Majida</creatorcontrib><creatorcontrib>Bataille, Regis</creatorcontrib><creatorcontrib>Piechaczyk, Martine</creatorcontrib><creatorcontrib>Salhi, Sharon Lynn</creatorcontrib><creatorcontrib>Pau, Bernard</creatorcontrib><creatorcontrib>Bastide, Madeleine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouanani, Majida</au><au>Bataille, Regis</au><au>Piechaczyk, Martine</au><au>Salhi, Sharon Lynn</au><au>Pau, Bernard</au><au>Bastide, Madeleine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoimmunity to human thyroglobulin: Respective epitopic specificity patterns of anti‐human thyroglobulin autoantibodies in patients with sjögren's syndrome and patients with hashimoto's thyroiditis</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1991-12</date><risdate>1991</risdate><volume>34</volume><issue>12</issue><spage>1585</spage><epage>1593</epage><pages>1585-1593</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><abstract>We evaluated the epitopic specificity pattern of anti‐human thyroglobulin (anti‐hTg) autoantibodies from patients with primary Sjögren's syndrome (SS). All of the primary SS sera tested contained both IgG and IgM anti‐hTg autoantibodies recognizing at least 1 region on hTg; in 65% of the cases, 3 or more regions were recognized. A strong recognition of region II, as is seen in Hashimoto's thyroiditis, was associated with thyroid disorder in primary SS. These results emphasize the importance of region II in autoimmune thyroid disease.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>1720958</pmid><doi>10.1002/art.1780341218</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0004-3591 |
| ispartof | Arthritis and rheumatism, 1991-12, Vol.34 (12), p.1585-1593 |
| issn | 0004-3591 1529-0131 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72551145 |
| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Adult Aged Antibodies, Monoclonal Antibody Specificity Autoantibodies - immunology Autoimmunity Enzyme-Linked Immunosorbent Assay Epitopes - immunology Female Humans Immunoglobulin A - analysis Immunoglobulin G - analysis Male Middle Aged Sjogren's Syndrome - blood Sjogren's Syndrome - immunology Thyroglobulin - immunology Thyroiditis, Autoimmune - blood Thyroiditis, Autoimmune - immunology |
| title | Autoimmunity to human thyroglobulin: Respective epitopic specificity patterns of anti‐human thyroglobulin autoantibodies in patients with sjögren's syndrome and patients with hashimoto's thyroiditis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T06%3A52%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Autoimmunity%20to%20human%20thyroglobulin:%20Respective%20epitopic%20specificity%20patterns%20of%20anti%E2%80%90human%20thyroglobulin%20autoantibodies%20in%20patients%20with%20sj%C3%B6gren's%20syndrome%20and%20patients%20with%20hashimoto's%20thyroiditis&rft.jtitle=Arthritis%20and%20rheumatism&rft.au=Bouanani,%20Majida&rft.date=1991-12&rft.volume=34&rft.issue=12&rft.spage=1585&rft.epage=1593&rft.pages=1585-1593&rft.issn=0004-3591&rft.eissn=1529-0131&rft_id=info:doi/10.1002/art.1780341218&rft_dat=%3Cproquest_cross%3E72551145%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72551145&rft_id=info:pmid/1720958&rfr_iscdi=true |