Cellular localization of müllerian inhibiting substance messenger ribonucleic acid during human ovarian follicular development
Müllerian inhibiting substance is expressed in the human reproductive system and has been associated with oocyte meiotic arrest. In situ hybridization was used to selectively localize ovarian cells containing high levels of müllerian inhibiting substance messenger ribonucleic acid, a müllerian inhib...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1991-12, Vol.165 (6), p.1881-1886 |
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| container_end_page | 1886 |
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| container_issue | 6 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 165 |
| creator | Whitman, Gail F. Pantazis, Cooley G. |
| description | Müllerian inhibiting substance is expressed in the human reproductive system and has been associated with oocyte meiotic arrest. In situ hybridization was used to selectively localize ovarian cells containing high levels of müllerian inhibiting substance messenger ribonucleic acid, a müllerian inhibiting substance precursor, during different stages of human follicular development. Müllerian inhibiting substance transcript was noted in the granulosa cells of primordial, primary, and antral follicles. Surprisingly, transcript was also identified within the cytoplasm of oocytes and throughout the ovarian stroma. Controls included sense oligoprobe, positive and negative tissue controls, and treatments minus the detection antibody. Localization of transcript within the cytoplasm demonstrates that active transcription of müllerian inhibiting substance messenger ribonucleic acid occurs within both fetal and adult human female gonads. The presence of müllerian inhibiting substance messenger ribonucleic acid within oocyte cytoplasm could implicate an autocrine role for müllerian inhibiting substance-derived peptides in the establishment of oocyte competence. (AM J OBSTET GYNECOL 1991;165:1881-6.) |
| doi_str_mv | 10.1016/0002-9378(91)90050-2 |
| format | Article |
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In situ hybridization was used to selectively localize ovarian cells containing high levels of müllerian inhibiting substance messenger ribonucleic acid, a müllerian inhibiting substance precursor, during different stages of human follicular development. Müllerian inhibiting substance transcript was noted in the granulosa cells of primordial, primary, and antral follicles. Surprisingly, transcript was also identified within the cytoplasm of oocytes and throughout the ovarian stroma. Controls included sense oligoprobe, positive and negative tissue controls, and treatments minus the detection antibody. Localization of transcript within the cytoplasm demonstrates that active transcription of müllerian inhibiting substance messenger ribonucleic acid occurs within both fetal and adult human female gonads. The presence of müllerian inhibiting substance messenger ribonucleic acid within oocyte cytoplasm could implicate an autocrine role for müllerian inhibiting substance-derived peptides in the establishment of oocyte competence. (AM J OBSTET GYNECOL 1991;165:1881-6.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(91)90050-2</identifier><identifier>PMID: 1750488</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Adult ; Age Factors ; Anti-Mullerian Hormone ; Biological and medical sciences ; digoxigenin ; Female ; Fundamental and applied biological sciences. Psychology ; Glycoproteins ; Growth Inhibitors - genetics ; Hormone metabolism and regulation ; Humans ; in situ hybridization ; Infant ; Mammalian female genital system ; messenger ribonucleic acid (mRNA) ; Müllerian inhibiting substance (MIS) ; Nucleic Acid Hybridization ; oocyte competence ; Ovary - chemistry ; RNA, Messenger - analysis ; Testicular Hormones - genetics ; Vertebrates: reproduction</subject><ispartof>American journal of obstetrics and gynecology, 1991-12, Vol.165 (6), p.1881-1886</ispartof><rights>1991 Mosby</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-3a13379b934eafb505340b32d0501672171b49af19fd4ec86222777ad397c1b33</citedby><cites>FETCH-LOGICAL-c386t-3a13379b934eafb505340b32d0501672171b49af19fd4ec86222777ad397c1b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(91)90050-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5163365$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1750488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whitman, Gail F.</creatorcontrib><creatorcontrib>Pantazis, Cooley G.</creatorcontrib><title>Cellular localization of müllerian inhibiting substance messenger ribonucleic acid during human ovarian follicular development</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Müllerian inhibiting substance is expressed in the human reproductive system and has been associated with oocyte meiotic arrest. In situ hybridization was used to selectively localize ovarian cells containing high levels of müllerian inhibiting substance messenger ribonucleic acid, a müllerian inhibiting substance precursor, during different stages of human follicular development. Müllerian inhibiting substance transcript was noted in the granulosa cells of primordial, primary, and antral follicles. Surprisingly, transcript was also identified within the cytoplasm of oocytes and throughout the ovarian stroma. Controls included sense oligoprobe, positive and negative tissue controls, and treatments minus the detection antibody. Localization of transcript within the cytoplasm demonstrates that active transcription of müllerian inhibiting substance messenger ribonucleic acid occurs within both fetal and adult human female gonads. The presence of müllerian inhibiting substance messenger ribonucleic acid within oocyte cytoplasm could implicate an autocrine role for müllerian inhibiting substance-derived peptides in the establishment of oocyte competence. (AM J OBSTET GYNECOL 1991;165:1881-6.)</description><subject>Adult</subject><subject>Age Factors</subject><subject>Anti-Mullerian Hormone</subject><subject>Biological and medical sciences</subject><subject>digoxigenin</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycoproteins</subject><subject>Growth Inhibitors - genetics</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>in situ hybridization</subject><subject>Infant</subject><subject>Mammalian female genital system</subject><subject>messenger ribonucleic acid (mRNA)</subject><subject>Müllerian inhibiting substance (MIS)</subject><subject>Nucleic Acid Hybridization</subject><subject>oocyte competence</subject><subject>Ovary - chemistry</subject><subject>RNA, Messenger - analysis</subject><subject>Testicular Hormones - genetics</subject><subject>Vertebrates: reproduction</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMuKFDEUhoMoYzv6BgpZiOiiNJeqSmUzIM14gQE3ug65nJqJpJI2qWrQjS82u3kxU93NuJtVCOf7_-R8CL2k5D0ltP9ACGGN5GJ4K-k7SUhHGvYIbSiRoumHfniMNvfIU_SslJ_rlUl2hs6o6Eg7DBv0dwshLEFnHJLVwf_Rs08RpxFPd7chQPY6Yh9vvPGzj9e4LKbMOlrAE5QC8Royzt6kuNgA3mJtvcNuySt7s0w1nPb6UDKmELw9POVgDyHtJojzc_Rk1KHAi9N5jn58uvy-_dJcffv8dfvxqrF86OeGa8q5kEbyFvRoOtLxlhjOXN2a9oJRQU0r9Ujl6FqwQ88YE0Jox6Ww1HB-jt4ce3c5_VqgzGryxdbddYS0FCVY15GBrWB7BG1OpWQY1S77SeffihK1elerRbVKVZKqg3fFauzVqX8xE7j_oaPoOn99mutSPY-5OvTlHutoz3nfVeziiEF1sfeQVbEeqm7nM9hZueQf_sc_mJihdQ</recordid><startdate>19911201</startdate><enddate>19911201</enddate><creator>Whitman, Gail F.</creator><creator>Pantazis, Cooley G.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19911201</creationdate><title>Cellular localization of müllerian inhibiting substance messenger ribonucleic acid during human ovarian follicular development</title><author>Whitman, Gail F. ; Pantazis, Cooley G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-3a13379b934eafb505340b32d0501672171b49af19fd4ec86222777ad397c1b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Anti-Mullerian Hormone</topic><topic>Biological and medical sciences</topic><topic>digoxigenin</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycoproteins</topic><topic>Growth Inhibitors - genetics</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>in situ hybridization</topic><topic>Infant</topic><topic>Mammalian female genital system</topic><topic>messenger ribonucleic acid (mRNA)</topic><topic>Müllerian inhibiting substance (MIS)</topic><topic>Nucleic Acid Hybridization</topic><topic>oocyte competence</topic><topic>Ovary - chemistry</topic><topic>RNA, Messenger - analysis</topic><topic>Testicular Hormones - genetics</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitman, Gail F.</creatorcontrib><creatorcontrib>Pantazis, Cooley G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whitman, Gail F.</au><au>Pantazis, Cooley G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular localization of müllerian inhibiting substance messenger ribonucleic acid during human ovarian follicular development</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>165</volume><issue>6</issue><spage>1881</spage><epage>1886</epage><pages>1881-1886</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Müllerian inhibiting substance is expressed in the human reproductive system and has been associated with oocyte meiotic arrest. In situ hybridization was used to selectively localize ovarian cells containing high levels of müllerian inhibiting substance messenger ribonucleic acid, a müllerian inhibiting substance precursor, during different stages of human follicular development. Müllerian inhibiting substance transcript was noted in the granulosa cells of primordial, primary, and antral follicles. Surprisingly, transcript was also identified within the cytoplasm of oocytes and throughout the ovarian stroma. Controls included sense oligoprobe, positive and negative tissue controls, and treatments minus the detection antibody. Localization of transcript within the cytoplasm demonstrates that active transcription of müllerian inhibiting substance messenger ribonucleic acid occurs within both fetal and adult human female gonads. The presence of müllerian inhibiting substance messenger ribonucleic acid within oocyte cytoplasm could implicate an autocrine role for müllerian inhibiting substance-derived peptides in the establishment of oocyte competence. (AM J OBSTET GYNECOL 1991;165:1881-6.)</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>1750488</pmid><doi>10.1016/0002-9378(91)90050-2</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1991-12, Vol.165 (6), p.1881-1886 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Age Factors Anti-Mullerian Hormone Biological and medical sciences digoxigenin Female Fundamental and applied biological sciences. Psychology Glycoproteins Growth Inhibitors - genetics Hormone metabolism and regulation Humans in situ hybridization Infant Mammalian female genital system messenger ribonucleic acid (mRNA) Müllerian inhibiting substance (MIS) Nucleic Acid Hybridization oocyte competence Ovary - chemistry RNA, Messenger - analysis Testicular Hormones - genetics Vertebrates: reproduction |
| title | Cellular localization of müllerian inhibiting substance messenger ribonucleic acid during human ovarian follicular development |
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