Heart Failure Augments the Cardiovascular and Renal Effects of Neutral Endopeptidase Inhibition in Rats

We compared the cardiovascular and renal actions of the neutral endopeptidase (NEP) inhibitor, SQ 28,603, in normal rats and in rats with healed myocardial infarcts. The infarcted rats were studied in the conscious state 8 weeks after ligation of the left main coronary artery and 4 h after placement...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1991-09, Vol.18 (3), p.308-316
Hauptverfasser:	Trippodo, Nick C, Gabel, Robert A, Harvey, Charlotte M, Asaad, Magdi M, Rogers, W Lynn
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Animals Biological and medical sciences Blood Pressure - drug effects Body Weight - drug effects Cardiovascular system Central Venous Pressure - drug effects Heart Failure - metabolism Heart Failure - physiopathology Heart Rate - drug effects Hemodynamics - drug effects Kidney - drug effects Male Medical sciences Miscellaneous Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Neprilysin - antagonists & inhibitors Neprilysin - pharmacology Pharmacology. Drug treatments Protease Inhibitors - pharmacology Rats Rats, Inbred Strains
Online-Zugang:	Volltext
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