IL-6 promoter polymorphisms in rheumatoid arthritis
We investigated the possible association between the IL-6 promoter polymorphisms, at positions -622 and -174, and susceptiblity to, and/or outcome of, rheumatoid arthritis (RA). A total of 163 patients with RA and 157 healthy controls were genotyped for IL-6 using a PCR-RFLP method. The -622 and -17...
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| Veröffentlicht in: | Genes and immunity 2000-06, Vol.1 (5), p.338-340 |
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| creator | Pascual, M Nieto, A Matarán, L Balsa, A Pascual-Salcedo, D Martín, J |
| description | We investigated the possible association between the IL-6 promoter polymorphisms, at positions -622 and -174, and susceptiblity to, and/or outcome of, rheumatoid arthritis (RA). A total of 163 patients with RA and 157 healthy controls were genotyped for IL-6 using a PCR-RFLP method. The -622 and -174 alleles were in complete linkage disequilibrium. No difference was observed in the distribution of IL-6 promoter genotype or allele frequencies between RA patients and controls. However, a significant difference in the mean age at disease onset between IL-6 genotypes was observed. The present data appear to rule out an important role of IL-6 promoter polymorphisms in the susceptibility to RA. However, IL-6 genotypes may contribute to the pathogenesis of the disease by influencing the age at disease onset. |
| doi_str_mv | 10.1038/sj.gene.6363677 |
| format | Article |
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A total of 163 patients with RA and 157 healthy controls were genotyped for IL-6 using a PCR-RFLP method. The -622 and -174 alleles were in complete linkage disequilibrium. No difference was observed in the distribution of IL-6 promoter genotype or allele frequencies between RA patients and controls. However, a significant difference in the mean age at disease onset between IL-6 genotypes was observed. The present data appear to rule out an important role of IL-6 promoter polymorphisms in the susceptibility to RA. However, IL-6 genotypes may contribute to the pathogenesis of the disease by influencing the age at disease onset.</description><identifier>ISSN: 1466-4879</identifier><identifier>EISSN: 1476-5470</identifier><identifier>DOI: 10.1038/sj.gene.6363677</identifier><identifier>PMID: 11196696</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Adult ; Age of Onset ; Alleles ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; Case-Control Studies ; Cytokines ; Gene Frequency ; Genes ; Genotype ; Genotype & phenotype ; Humans ; Interleukin 6 ; Interleukin-6 - genetics ; Linkage Disequilibrium ; Middle Aged ; Pathogenesis ; Polymerase Chain Reaction ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Promoter Regions, Genetic ; Restriction fragment length polymorphism ; Rheumatoid arthritis ; Tumor necrosis factor-TNF</subject><ispartof>Genes and immunity, 2000-06, Vol.1 (5), p.338-340</ispartof><rights>Copyright Nature Publishing Group Jun 2000</rights><rights>Macmillan Publishers Limited 2000.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-d17898f708c666db906980bf6f09a66e5b31760d461b21a7805c2c993b04f9713</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11196696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pascual, M</creatorcontrib><creatorcontrib>Nieto, A</creatorcontrib><creatorcontrib>Matarán, L</creatorcontrib><creatorcontrib>Balsa, A</creatorcontrib><creatorcontrib>Pascual-Salcedo, D</creatorcontrib><creatorcontrib>Martín, J</creatorcontrib><title>IL-6 promoter polymorphisms in rheumatoid arthritis</title><title>Genes and immunity</title><addtitle>Genes Immun</addtitle><description>We investigated the possible association between the IL-6 promoter polymorphisms, at positions -622 and -174, and susceptiblity to, and/or outcome of, rheumatoid arthritis (RA). A total of 163 patients with RA and 157 healthy controls were genotyped for IL-6 using a PCR-RFLP method. The -622 and -174 alleles were in complete linkage disequilibrium. No difference was observed in the distribution of IL-6 promoter genotype or allele frequencies between RA patients and controls. However, a significant difference in the mean age at disease onset between IL-6 genotypes was observed. The present data appear to rule out an important role of IL-6 promoter polymorphisms in the susceptibility to RA. However, IL-6 genotypes may contribute to the pathogenesis of the disease by influencing the age at disease onset.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Alleles</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Case-Control Studies</subject><subject>Cytokines</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - genetics</subject><subject>Linkage Disequilibrium</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Promoter Regions, Genetic</subject><subject>Restriction fragment length polymorphism</subject><subject>Rheumatoid arthritis</subject><subject>Tumor necrosis factor-TNF</subject><issn>1466-4879</issn><issn>1476-5470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0c1LwzAYBvAgitPp2ZsUBW_d8jbpm-Qow4_BwIueQz9S19I2NWkP--_N2EAQRHJ4c_jl4Q0PITdAF0CZXPpm8Wl6s0AWjhAn5AK4wDjlgp7u74gxl0LNyKX3DaWAgOqczABAISq8IGy9iTEanO3saFw02HbXWTdsa9_5qO4jtzVTl422LqPMjVtXj7W_ImdV1npzfZxz8vH89L56jTdvL-vV4yYuOE_HuAQhlawElQUilrmiqCTNK6yoyhBNmjMQSEuOkCeQCUnTIimUYjnllRLA5uThkBvW-5qMH3VX-8K0bdYbO3ktkpSnwMS_ECQIRdMkwPtfsLGT68MndIIcBAtpaVB3fyqQUiWBBbQ8oMJZ752p9ODqLnM7DVTvu9G-0ftu9LGb8OL2GDvlnSl__LEM9g0_Togd</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Pascual, M</creator><creator>Nieto, A</creator><creator>Matarán, L</creator><creator>Balsa, A</creator><creator>Pascual-Salcedo, D</creator><creator>Martín, J</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>IL-6 promoter polymorphisms in rheumatoid arthritis</title><author>Pascual, M ; Nieto, A ; Matarán, L ; Balsa, A ; Pascual-Salcedo, D ; Martín, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-d17898f708c666db906980bf6f09a66e5b31760d461b21a7805c2c993b04f9713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Alleles</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Case-Control Studies</topic><topic>Cytokines</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - genetics</topic><topic>Linkage Disequilibrium</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Promoter Regions, Genetic</topic><topic>Restriction fragment length polymorphism</topic><topic>Rheumatoid arthritis</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pascual, M</creatorcontrib><creatorcontrib>Nieto, A</creatorcontrib><creatorcontrib>Matarán, L</creatorcontrib><creatorcontrib>Balsa, A</creatorcontrib><creatorcontrib>Pascual-Salcedo, D</creatorcontrib><creatorcontrib>Martín, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genes and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pascual, M</au><au>Nieto, A</au><au>Matarán, L</au><au>Balsa, A</au><au>Pascual-Salcedo, D</au><au>Martín, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-6 promoter polymorphisms in rheumatoid arthritis</atitle><jtitle>Genes and immunity</jtitle><addtitle>Genes Immun</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>1</volume><issue>5</issue><spage>338</spage><epage>340</epage><pages>338-340</pages><issn>1466-4879</issn><eissn>1476-5470</eissn><abstract>We investigated the possible association between the IL-6 promoter polymorphisms, at positions -622 and -174, and susceptiblity to, and/or outcome of, rheumatoid arthritis (RA). A total of 163 patients with RA and 157 healthy controls were genotyped for IL-6 using a PCR-RFLP method. The -622 and -174 alleles were in complete linkage disequilibrium. No difference was observed in the distribution of IL-6 promoter genotype or allele frequencies between RA patients and controls. However, a significant difference in the mean age at disease onset between IL-6 genotypes was observed. The present data appear to rule out an important role of IL-6 promoter polymorphisms in the susceptibility to RA. However, IL-6 genotypes may contribute to the pathogenesis of the disease by influencing the age at disease onset.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>11196696</pmid><doi>10.1038/sj.gene.6363677</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Age of Onset Alleles Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Case-Control Studies Cytokines Gene Frequency Genes Genotype Genotype & phenotype Humans Interleukin 6 Interleukin-6 - genetics Linkage Disequilibrium Middle Aged Pathogenesis Polymerase Chain Reaction Polymorphism Polymorphism, Genetic Polymorphism, Restriction Fragment Length Promoter Regions, Genetic Restriction fragment length polymorphism Rheumatoid arthritis Tumor necrosis factor-TNF |
| title | IL-6 promoter polymorphisms in rheumatoid arthritis |
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