Blood pressure responses to whole-body cold exposure : effect of carvedilol
The aim of this study was to test the effects of carvedilol on blood pressure (BP) and heart rate (HR) during whole-body cold exposure in hypertensive and normotensive subjects. Ten hypertensive and twelve normotensive subjects were exposed to cold (-15 degrees C, wind 3.5 m/s) three times for 15 mi...
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| Veröffentlicht in: | European journal of clinical pharmacology 2000-12, Vol.56 (9-10), p.637-642 |
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| container_title | European journal of clinical pharmacology |
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| creator | KOMULAINEN, Silja TÄHTINEN, Tuula RINTAMÄKI, Hannu VIROKANNAS, Hannu KEINÄNEN-KIUKAANNIEMI, Sirkka |
| description | The aim of this study was to test the effects of carvedilol on blood pressure (BP) and heart rate (HR) during whole-body cold exposure in hypertensive and normotensive subjects.
Ten hypertensive and twelve normotensive subjects were exposed to cold (-15 degrees C, wind 3.5 m/s) three times for 15 min with a 1-week interval between the exposures. The study design was made according to a randomised double-blind, crossover method. Before the cold exposures the subjects ingested carvedilol or placebo once a day (carvedilol 12.5 mg/day for 2 days and then 25 mg/day for 5 days) for 1 week. The systolic (SBP) and diastolic (DBP) blood pressure and HR were measured every 3 min during the test procedures using an indirect ambulatory blood pressure monitor device (ABPM-02, Meditech Co.).
In the hypertensive group, the cold exposure increased SBP/DBP from 119/75 mmHg to 143/96 mmHg during carvedilol treatment (P |
| doi_str_mv | 10.1007/s002280000208 |
| format | Article |
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Ten hypertensive and twelve normotensive subjects were exposed to cold (-15 degrees C, wind 3.5 m/s) three times for 15 min with a 1-week interval between the exposures. The study design was made according to a randomised double-blind, crossover method. Before the cold exposures the subjects ingested carvedilol or placebo once a day (carvedilol 12.5 mg/day for 2 days and then 25 mg/day for 5 days) for 1 week. The systolic (SBP) and diastolic (DBP) blood pressure and HR were measured every 3 min during the test procedures using an indirect ambulatory blood pressure monitor device (ABPM-02, Meditech Co.).
In the hypertensive group, the cold exposure increased SBP/DBP from 119/75 mmHg to 143/96 mmHg during carvedilol treatment (P<0.001) and from 132/85 mmHg to 159/106 mmHg during placebo (P<0.001). In the normotensive group the cold exposure increased SBP/DBP from 112/72 mmHg to 142/93 mmHg during carvedilol treatment (P<0.001) and from 121/75 mmHg to 147/98 mmHg during placebo (P<0.001). In the hypertensive group, the levels of SBP, DBP and MAP (mean arterial pressure) were significantly lower with carvedilol than with placebo during the cold exposure although carvedilol did not affect the cold-induced rise of the BP. The BPs were lower also with carvedilol in the normotensive group than the placebo during the cold exposure, but the differences were smaller than in the hypertensive group. Carvedilol decreased the BP more the higher the initial mean SBP/DBP was with placebo during the cold exposure.
Carvedilol reduced the BP during the cold exposure, especially in the hypertensive subjects but also in normotensive ones, without effect on the cold-induced rise of the BP.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s002280000208</identifier><identifier>PMID: 11214769</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Adult ; Antihypertensive agents ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Carbazoles - pharmacology ; Cardiovascular system ; Carvedilol ; Clinical trials ; Cold ; Cold Temperature ; Cross-Over Studies ; Double-Blind Method ; Female ; Heart rate ; Heart Rate - drug effects ; Hot Temperature ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Propanolamines - pharmacology ; Wind</subject><ispartof>European journal of clinical pharmacology, 2000-12, Vol.56 (9-10), p.637-642</ispartof><rights>2001 INIST-CNRS</rights><rights>Springer-Verlag 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-79a5ec5e2c6a8457642a17234b3dbb0c2bfda15b9ab4b74598a188b8e0568fd13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=857450$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11214769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOMULAINEN, Silja</creatorcontrib><creatorcontrib>TÄHTINEN, Tuula</creatorcontrib><creatorcontrib>RINTAMÄKI, Hannu</creatorcontrib><creatorcontrib>VIROKANNAS, Hannu</creatorcontrib><creatorcontrib>KEINÄNEN-KIUKAANNIEMI, Sirkka</creatorcontrib><title>Blood pressure responses to whole-body cold exposure : effect of carvedilol</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>The aim of this study was to test the effects of carvedilol on blood pressure (BP) and heart rate (HR) during whole-body cold exposure in hypertensive and normotensive subjects.
Ten hypertensive and twelve normotensive subjects were exposed to cold (-15 degrees C, wind 3.5 m/s) three times for 15 min with a 1-week interval between the exposures. The study design was made according to a randomised double-blind, crossover method. Before the cold exposures the subjects ingested carvedilol or placebo once a day (carvedilol 12.5 mg/day for 2 days and then 25 mg/day for 5 days) for 1 week. The systolic (SBP) and diastolic (DBP) blood pressure and HR were measured every 3 min during the test procedures using an indirect ambulatory blood pressure monitor device (ABPM-02, Meditech Co.).
In the hypertensive group, the cold exposure increased SBP/DBP from 119/75 mmHg to 143/96 mmHg during carvedilol treatment (P<0.001) and from 132/85 mmHg to 159/106 mmHg during placebo (P<0.001). In the normotensive group the cold exposure increased SBP/DBP from 112/72 mmHg to 142/93 mmHg during carvedilol treatment (P<0.001) and from 121/75 mmHg to 147/98 mmHg during placebo (P<0.001). In the hypertensive group, the levels of SBP, DBP and MAP (mean arterial pressure) were significantly lower with carvedilol than with placebo during the cold exposure although carvedilol did not affect the cold-induced rise of the BP. The BPs were lower also with carvedilol in the normotensive group than the placebo during the cold exposure, but the differences were smaller than in the hypertensive group. Carvedilol decreased the BP more the higher the initial mean SBP/DBP was with placebo during the cold exposure.
Carvedilol reduced the BP during the cold exposure, especially in the hypertensive subjects but also in normotensive ones, without effect on the cold-induced rise of the BP.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Adult</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Carbazoles - pharmacology</subject><subject>Cardiovascular system</subject><subject>Carvedilol</subject><subject>Clinical trials</subject><subject>Cold</subject><subject>Cold Temperature</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Heart rate</subject><subject>Heart Rate - drug effects</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Propanolamines - pharmacology</subject><subject>Wind</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90ctPHDEMB-AIgWC75ci1ilQJ9TJg5zHJ9AaoDwRSL-15lGQ86qLsZprstOW_Jy2rPjjgiy-ffpZtxk4QzhDAnBcAISzUEmD32AKVFA2Cwn22AJDYtJ2BI_ailDsA1B3IQ3aEKFCZtluwm8uY0sCnTKXMmXjtU9oUKnyb-I-vKVLj03DPQ4oDp59T-q3echpHClueRh5c_k7DKqb4kh2MLhY63vUl-_L-3eerj83tpw_XVxe3TZDGbhvTOU1Bkwits0qbVgmHRkjl5eA9BOHHwaH2nfPKG6U769Babwl0a8cB5ZKdPuZOOX2bqWz79aoEitFtKM2lN0IrJayo8M2zEIW0iAasrvT1E3qX5rypa1RlW6OwrddcsuZRhZxKyTT2U16tXb7vEfpf7-j_e0f1r3aps1_T8Ffv7v_PWFeCi2N2m7Aqf5zVdX-QD4vOj4A</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>KOMULAINEN, Silja</creator><creator>TÄHTINEN, Tuula</creator><creator>RINTAMÄKI, Hannu</creator><creator>VIROKANNAS, Hannu</creator><creator>KEINÄNEN-KIUKAANNIEMI, Sirkka</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Blood pressure responses to whole-body cold exposure : effect of carvedilol</title><author>KOMULAINEN, Silja ; TÄHTINEN, Tuula ; RINTAMÄKI, Hannu ; VIROKANNAS, Hannu ; KEINÄNEN-KIUKAANNIEMI, Sirkka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-79a5ec5e2c6a8457642a17234b3dbb0c2bfda15b9ab4b74598a188b8e0568fd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Adult</topic><topic>Antihypertensive agents</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Carbazoles - pharmacology</topic><topic>Cardiovascular system</topic><topic>Carvedilol</topic><topic>Clinical trials</topic><topic>Cold</topic><topic>Cold Temperature</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Heart rate</topic><topic>Heart Rate - drug effects</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Propanolamines - pharmacology</topic><topic>Wind</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOMULAINEN, Silja</creatorcontrib><creatorcontrib>TÄHTINEN, Tuula</creatorcontrib><creatorcontrib>RINTAMÄKI, Hannu</creatorcontrib><creatorcontrib>VIROKANNAS, Hannu</creatorcontrib><creatorcontrib>KEINÄNEN-KIUKAANNIEMI, Sirkka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOMULAINEN, Silja</au><au>TÄHTINEN, Tuula</au><au>RINTAMÄKI, Hannu</au><au>VIROKANNAS, Hannu</au><au>KEINÄNEN-KIUKAANNIEMI, Sirkka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood pressure responses to whole-body cold exposure : effect of carvedilol</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>56</volume><issue>9-10</issue><spage>637</spage><epage>642</epage><pages>637-642</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>The aim of this study was to test the effects of carvedilol on blood pressure (BP) and heart rate (HR) during whole-body cold exposure in hypertensive and normotensive subjects.
Ten hypertensive and twelve normotensive subjects were exposed to cold (-15 degrees C, wind 3.5 m/s) three times for 15 min with a 1-week interval between the exposures. The study design was made according to a randomised double-blind, crossover method. Before the cold exposures the subjects ingested carvedilol or placebo once a day (carvedilol 12.5 mg/day for 2 days and then 25 mg/day for 5 days) for 1 week. The systolic (SBP) and diastolic (DBP) blood pressure and HR were measured every 3 min during the test procedures using an indirect ambulatory blood pressure monitor device (ABPM-02, Meditech Co.).
In the hypertensive group, the cold exposure increased SBP/DBP from 119/75 mmHg to 143/96 mmHg during carvedilol treatment (P<0.001) and from 132/85 mmHg to 159/106 mmHg during placebo (P<0.001). In the normotensive group the cold exposure increased SBP/DBP from 112/72 mmHg to 142/93 mmHg during carvedilol treatment (P<0.001) and from 121/75 mmHg to 147/98 mmHg during placebo (P<0.001). In the hypertensive group, the levels of SBP, DBP and MAP (mean arterial pressure) were significantly lower with carvedilol than with placebo during the cold exposure although carvedilol did not affect the cold-induced rise of the BP. The BPs were lower also with carvedilol in the normotensive group than the placebo during the cold exposure, but the differences were smaller than in the hypertensive group. Carvedilol decreased the BP more the higher the initial mean SBP/DBP was with placebo during the cold exposure.
Carvedilol reduced the BP during the cold exposure, especially in the hypertensive subjects but also in normotensive ones, without effect on the cold-induced rise of the BP.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>11214769</pmid><doi>10.1007/s002280000208</doi><tpages>6</tpages></addata></record> |
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| subjects | Adrenergic beta-Antagonists - pharmacology Adult Antihypertensive agents Biological and medical sciences Blood pressure Blood Pressure - drug effects Carbazoles - pharmacology Cardiovascular system Carvedilol Clinical trials Cold Cold Temperature Cross-Over Studies Double-Blind Method Female Heart rate Heart Rate - drug effects Hot Temperature Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Propanolamines - pharmacology Wind |
| title | Blood pressure responses to whole-body cold exposure : effect of carvedilol |
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