Synthesis and calcium antagonistic activity of 2,6,6-trimethyl-3-carbomethoxy(ethoxy)-4-aryl-1,4,5,6,7,8-hexahydroquinoline derivatives

Twelve new 2,6,6-trimethyl-3-carbomethoxy(ethoxy)-4-aryl-1,4,5,6,7,8-hexahydroquinoline derivatives have been prepared. Their structures were confirmed by IR, 1H NMR, mass and elemental analysis. The calcium antagonistic activity of these compounds was tested in rat aortic rings precontracted with 3...

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Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 2000-11, Vol.55 (11), p.665-668
Hauptverfasser:	SIMSEK, Rahime, ISMAILOGLU, U. Burcin, SAFAK, Cihat, SAHIN-ERDEMLI, Inci
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Dihydropyridine Animals Aorta, Thoracic - drug effects Biological and medical sciences Calcium antagonistic activity Calcium Channel Blockers - chemical synthesis Calcium Channel Blockers - pharmacology Cardiovascular system Dihydropyridines - chemical synthesis Dihydropyridines - pharmacology Hexahydroquinoline In Vitro Techniques Magnetic Resonance Spectroscopy Male Mass Spectrometry Medical sciences Miscellaneous Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Pharmacology Pharmacology. Drug treatments Quinolines - chemistry Quinolines - pharmacology Rats Spectra Spectrophotometry, Infrared Spectroscopy, Fourier Transform Infrared
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