Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes

Susceptibility as opposed to resistance of mouse strains (e.g., BALB/c vs C57BL/6) to Leishmania major has been attributed to a defective Th1 and a predominant Th2-response, resulting in increased IL-4 and IgE production, and decreased interferon gamma (IFN gamma) production, macrophage activation a...

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Veröffentlicht in:	Genes and immunity 2000-02, Vol.1 (3), p.200-206
Hauptverfasser:	Lipoldová, M, Svobodová, M, Krulová, M, Havelková, H, Badalová, J, Nohýnková, E, Holán, V, Hart, A A, Volf, P, Demant, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Congenic Cell activation Female g-Interferon Genetic Linkage Genotype Genotypes Hybridization, Genetic Hybrids Immunoglobulin E In Vitro Techniques Inbreeding Interleukin 4 Leishmania major Leishmaniasis Leishmaniasis, Cutaneous - genetics Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - pathology Linkage analysis Lymphocyte Activation Lymphocytes T Macrophages Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred Strains Parasitic diseases Phenotype Phenotypes Polymorphism, Genetic Species Specificity Strains (organisms) Susceptibility Th1 Cells - immunology Th2 Cells - immunology γ-Interferon
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