Identification and characterization of a 19q12 amplicon in esophageal adenocarcinomas reveals Cyclin E as the best candidate gene for this amplicon

Genomic DNA amplification in tumors is frequently associated with an increased gene copy number of oncogenes or other cancer-related genes. We have used a two-dimensional whole-genome scanning technique to identify gene amplification events in esophageal adenocarcinomas. A multicopy genomic fragment...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-12, Vol.60 (24), p.7021-7027
Hauptverfasser:	LIN LIN, PRESCOTT, Michael S, ZHOUQIN ZHU, PUJA SINGH, CHUN, Sang Y, KUICK, Rork D, HANASH, Samir M, ORRINGER, Mark B, GLOVER, Thomas W, BEER, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Biological and medical sciences Blotting, Southern Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology chromosome 19 Chromosome Mapping Chromosomes, Human, Pair 19 Cloning, Molecular Contig Mapping Cyclin E - biosynthesis Cyclin E - genetics Electrophoresis, Gel, Two-Dimensional Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophagus Esophagus - metabolism Esophagus - pathology Expressed Sequence Tags Gastroenterology. Liver. Pancreas. Abdomen Humans Lung Neoplasms - genetics Medical sciences Models, Genetic Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Stomach Neoplasms - genetics Stomach Neoplasms - pathology Tumors
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