Changes in CREB-phosphorylation during recovery from major depression
For decades psychiatrists have been looking for biological state markers measurable by easy blood test in order to follow up and predict early on treatment response in patients with major depression. In the present study we investigated whether or not measuring CREB (cAMP-response-element-binding-pr...
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| Veröffentlicht in: | Journal of psychiatric research 2002-11, Vol.36 (6), p.369-375 |
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| creator | Koch, Jakob M Kell, Susanne Hinze-Selch, Dunja Aldenhoff, Josef B |
| description | For decades psychiatrists have been looking for biological state markers measurable by easy blood test in order to follow up and predict early on treatment response in patients with major depression. In the present study we investigated whether or not measuring CREB (cAMP-response-element-binding-protein) phosphorylation in peripheral blood T lymphocytes is a state marker of treatment response. CREB is an ubiquitous key-element of intracellular signal transduction cascades and its transcriptional activity depends on phosphorylation at Ser-133. Several studies in animals demonstrated that the transcriptional activity of CREB is up-regulated by antidepressant treatment. Therefore, it has been hypothesized that antidepressant treatment exerts its therapeutic effect by this mechanism. In the present study, we investigated CREB-phosphorylation in T-lymphocytes of 20 patients before and in the end of week one and two of either psychopharmacological or psychotherapeutic treatment. After two weeks, 15 patients fulfilled the criteria of treatment response (i.e. 30% reduction in HAMD score compared to baseline), whereas five patients did not. In the end of week two, the responders showed a significant increase in CREB-phosphorylation (
P=0.018) compared to the non-responders. This was true for all patients with either treatment regimen. In conclusion, these results indicate for the first time that the increase in CREB-phosphorylation might be a molecular state marker for the response to antidepressant treatment. |
| doi_str_mv | 10.1016/S0022-3956(02)00056-0 |
| format | Article |
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P=0.018) compared to the non-responders. This was true for all patients with either treatment regimen. In conclusion, these results indicate for the first time that the increase in CREB-phosphorylation might be a molecular state marker for the response to antidepressant treatment.</description><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic AMP Response Element-Binding Protein - metabolism</subject><subject>Cyclic AMP-responsive DNA-binding protein (CREB)</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - metabolism</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Individual psychotherapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuronal plasticity</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphorylation</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Psychotherapies. Psychological and clinical counseling</subject><subject>Psychotherapy</subject><subject>Recovery of Function</subject><subject>Signal Transduction - physiology</subject><subject>State marker</subject><subject>Treatment response</subject><subject>Treatments</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ElLxDAUwPEgio7LR1B6UfRQfdmayUl0GBcYEFzOIW1fNdI2YzIjzLc3s6BHDyGX33sJf0KOKVxSoMXVCwBjOdeyOAd2AQCyyGGLDOhQ6ZxypbfJ4Jfskf0YPxNSjIpdskcZ15yDHJDx6MP27xgz12ej5_FtPv3wMZ2waO3M-T6r58H171nAyn9jWGRN8F3W2U8fshqnAWNM6pDsNLaNeLS5D8jb3fh19JBPnu4fRzeTvBJSzfJSSts0YKVQiolaCAABXNkSJIoSa9FIIZQuG6i1RQrFUAtQGoalFLLUih-Qs_XeafBfc4wz07lYYdvaHv08GsUkLyQTCco1rIKPMWBjpsF1NiwMBbPsZ1b9zDKOAWZW_QykuZPNA_Oyw_pvahMsgdMNsLGybRNsX7n45wTVXOphctdrhynHt8NgYuWwr7B2KeXM1N7985UfVhKLSA</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Koch, Jakob M</creator><creator>Kell, Susanne</creator><creator>Hinze-Selch, Dunja</creator><creator>Aldenhoff, Josef B</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Changes in CREB-phosphorylation during recovery from major depression</title><author>Koch, Jakob M ; Kell, Susanne ; Hinze-Selch, Dunja ; Aldenhoff, Josef B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-b55aff0a547724d44004037ab05e4bed4f54479bf0d9ae10689407908b545b973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antidepressants</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic AMP Response Element-Binding Protein - metabolism</topic><topic>Cyclic AMP-responsive DNA-binding protein (CREB)</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Depressive Disorder, Major - metabolism</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Individual psychotherapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuronal plasticity</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphorylation</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Psychotherapies. Psychological and clinical counseling</topic><topic>Psychotherapy</topic><topic>Recovery of Function</topic><topic>Signal Transduction - physiology</topic><topic>State marker</topic><topic>Treatment response</topic><topic>Treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koch, Jakob M</creatorcontrib><creatorcontrib>Kell, Susanne</creatorcontrib><creatorcontrib>Hinze-Selch, Dunja</creatorcontrib><creatorcontrib>Aldenhoff, Josef B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koch, Jakob M</au><au>Kell, Susanne</au><au>Hinze-Selch, Dunja</au><au>Aldenhoff, Josef B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in CREB-phosphorylation during recovery from major depression</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>36</volume><issue>6</issue><spage>369</spage><epage>375</epage><pages>369-375</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><coden>JPYRA3</coden><abstract>For decades psychiatrists have been looking for biological state markers measurable by easy blood test in order to follow up and predict early on treatment response in patients with major depression. In the present study we investigated whether or not measuring CREB (cAMP-response-element-binding-protein) phosphorylation in peripheral blood T lymphocytes is a state marker of treatment response. CREB is an ubiquitous key-element of intracellular signal transduction cascades and its transcriptional activity depends on phosphorylation at Ser-133. Several studies in animals demonstrated that the transcriptional activity of CREB is up-regulated by antidepressant treatment. Therefore, it has been hypothesized that antidepressant treatment exerts its therapeutic effect by this mechanism. In the present study, we investigated CREB-phosphorylation in T-lymphocytes of 20 patients before and in the end of week one and two of either psychopharmacological or psychotherapeutic treatment. After two weeks, 15 patients fulfilled the criteria of treatment response (i.e. 30% reduction in HAMD score compared to baseline), whereas five patients did not. 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| subjects | Antidepressants Antidepressive Agents - therapeutic use Biological and medical sciences Blotting, Western Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-responsive DNA-binding protein (CREB) Depressive Disorder, Major - drug therapy Depressive Disorder, Major - metabolism DNA-Binding Proteins - metabolism Female Humans Individual psychotherapy Male Medical sciences Middle Aged Neuronal plasticity Neuronal Plasticity - physiology Neuropharmacology Pharmacology. Drug treatments Phosphorylation Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychotherapies. Psychological and clinical counseling Psychotherapy Recovery of Function Signal Transduction - physiology State marker Treatment response Treatments |
| title | Changes in CREB-phosphorylation during recovery from major depression |
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