Dissociation of analgesic and rewarding effects of endomorphin-1 in rats
The μ-receptor is the primary mediator of the effects of morphine and the endogenous opiates, endomorphin-1 and endomorphin-2. Here we demonstrate a dissociation of the analgesic and rewarding effects of endomorphin-1 in rats. Tail-flick results revealed that endomorphin-1 produced significant analg...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2000-12, Vol.21 (12), p.1871-1874 |
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| container_issue | 12 |
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| container_title | Peptides (New York, N.Y. : 1980) |
| container_volume | 21 |
| creator | Wilson, Aimee M Soignier, R.Denis Zadina, James E Kastin, Abba J Nores, William L Olson, Richard D Olson, Gayle A |
| description | The μ-receptor is the primary mediator of the effects of morphine and the endogenous opiates, endomorphin-1 and endomorphin-2. Here we demonstrate a dissociation of the analgesic and rewarding effects of endomorphin-1 in rats. Tail-flick results revealed that endomorphin-1 produced significant analgesic effects within 10-min after injection. However, it failed to show reward properties in the standard 45- min conditioned place preference (CPP) paradigm or in an abbreviated 10-min pairing which paralleled the time frame of the tail-flick findings. Morphine induced both analgesia and reward. Endomorphin-1 therefore is the first mu opiate shown to produce potent analgesia in the absence of reward behavior, and thus may have significant clinical potential. |
| doi_str_mv | 10.1016/S0196-9781(00)00340-5 |
| format | Article |
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Here we demonstrate a dissociation of the analgesic and rewarding effects of endomorphin-1 in rats. Tail-flick results revealed that endomorphin-1 produced significant analgesic effects within 10-min after injection. However, it failed to show reward properties in the standard 45- min conditioned place preference (CPP) paradigm or in an abbreviated 10-min pairing which paralleled the time frame of the tail-flick findings. Morphine induced both analgesia and reward. Endomorphin-1 therefore is the first mu opiate shown to produce potent analgesia in the absence of reward behavior, and thus may have significant clinical potential.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/S0196-9781(00)00340-5</identifier><identifier>PMID: 11150648</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Analgesics - pharmacology ; Animals ; Male ; Morphine - pharmacology ; Oligopeptides - pharmacology ; Rats ; Rats, Sprague-Dawley ; Reward ; Time Factors</subject><ispartof>Peptides (New York, N.Y. : 1980), 2000-12, Vol.21 (12), p.1871-1874</ispartof><rights>2000 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-3b88f6e37ac030006bdbcbe04ebc5b12c04c0cf0a2a4a3a3b4b96dedc5b327d53</citedby><cites>FETCH-LOGICAL-c505t-3b88f6e37ac030006bdbcbe04ebc5b12c04c0cf0a2a4a3a3b4b96dedc5b327d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196978100003405$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11150648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilson, Aimee M</creatorcontrib><creatorcontrib>Soignier, R.Denis</creatorcontrib><creatorcontrib>Zadina, James E</creatorcontrib><creatorcontrib>Kastin, Abba J</creatorcontrib><creatorcontrib>Nores, William L</creatorcontrib><creatorcontrib>Olson, Richard D</creatorcontrib><creatorcontrib>Olson, Gayle A</creatorcontrib><title>Dissociation of analgesic and rewarding effects of endomorphin-1 in rats</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>The μ-receptor is the primary mediator of the effects of morphine and the endogenous opiates, endomorphin-1 and endomorphin-2. 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Endomorphin-1 therefore is the first mu opiate shown to produce potent analgesia in the absence of reward behavior, and thus may have significant clinical potential.</description><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Male</subject><subject>Morphine - pharmacology</subject><subject>Oligopeptides - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reward</subject><subject>Time Factors</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaCsECwC49jOY4VQeUqVWABry49JMUrjYqcg_p6krWDJyiP5zNyZQ8gxhQsKNL98BlrlaVWU9AzgHIBxSMUOGdOyYKmgebVLxr_IiBzE-A4AnFflPhlRSgXkvByThxsXozdOdc63ia8T1apmjtGZvrJJwC8VrGvnCdY1mi4OCLbWL3xYvrk2pYlrk6C6eEj2atVEPNq-E_J6d_syfUhnT_eP0-tZagSILmW6LOscWaEMsH6hXFttNAJHbYSmmQFuwNSgMsUVU0xzXeUWbf_JssIKNiGnm7nL4D9WGDu5cNFg06gW_SrKIhNMlAXtQbEBTfAxBqzlMriFCt-SghwUyrVCOfiRAHKtUA4BJ9uAlV6g_evaOuuBqw2A_ZmfDoOMxmFr0LrQK5LWu38ifgBxnYEz</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Wilson, Aimee M</creator><creator>Soignier, R.Denis</creator><creator>Zadina, James E</creator><creator>Kastin, Abba J</creator><creator>Nores, William L</creator><creator>Olson, Richard D</creator><creator>Olson, Gayle A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Dissociation of analgesic and rewarding effects of endomorphin-1 in rats</title><author>Wilson, Aimee M ; Soignier, R.Denis ; Zadina, James E ; Kastin, Abba J ; Nores, William L ; Olson, Richard D ; Olson, Gayle A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-3b88f6e37ac030006bdbcbe04ebc5b12c04c0cf0a2a4a3a3b4b96dedc5b327d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Male</topic><topic>Morphine - pharmacology</topic><topic>Oligopeptides - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reward</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, Aimee M</creatorcontrib><creatorcontrib>Soignier, R.Denis</creatorcontrib><creatorcontrib>Zadina, James E</creatorcontrib><creatorcontrib>Kastin, Abba J</creatorcontrib><creatorcontrib>Nores, William L</creatorcontrib><creatorcontrib>Olson, Richard D</creatorcontrib><creatorcontrib>Olson, Gayle A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, Aimee M</au><au>Soignier, R.Denis</au><au>Zadina, James E</au><au>Kastin, Abba J</au><au>Nores, William L</au><au>Olson, Richard D</au><au>Olson, Gayle A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dissociation of analgesic and rewarding effects of endomorphin-1 in rats</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>21</volume><issue>12</issue><spage>1871</spage><epage>1874</epage><pages>1871-1874</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>The μ-receptor is the primary mediator of the effects of morphine and the endogenous opiates, endomorphin-1 and endomorphin-2. 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| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2000-12, Vol.21 (12), p.1871-1874 |
| issn | 0196-9781 1873-5169 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analgesics - pharmacology Animals Male Morphine - pharmacology Oligopeptides - pharmacology Rats Rats, Sprague-Dawley Reward Time Factors |
| title | Dissociation of analgesic and rewarding effects of endomorphin-1 in rats |
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