Methodology of clinical trials in hand osteoarthritis: Conventional and proposed tools
Summary Although very common, hand osteoarthritis (OA) is rarely the focus of clinical trials aimed at determining whether a drug is effective on its symptoms and/or anatomical progression. Besides the common difficulties met in trials in OA in general, the highly unpredictable course of hand OA pre...
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| Veröffentlicht in: | Osteoarthritis and cartilage 2000-01, Vol.8, p.S64-S69 |
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| container_title | Osteoarthritis and cartilage |
| container_volume | 8 |
| creator | Lequesne, M.G. Maheu, E. |
| description | Summary
Although very common, hand osteoarthritis (OA) is rarely the focus of clinical trials aimed at determining whether a drug is effective on its symptoms and/or anatomical progression. Besides the common difficulties met in trials in OA in general, the highly unpredictable course of hand OA presents specific challenges. However, hand OA is beginning to be considered as a potential model for the study of drugs in OA, since researchers now have at their disposal new clinical tools and radiological methods to assess with better accuracy and sensitivity either its symptomatic activity or its anatomical course.
The now well-known consensual recommendations for the design and conduct of clinical trials in OA are reviewed, and the specific clinical tools and radiological methods available for the assessment of hand OA detailed. Some specific recommendations for the design of clinical trials in hand OA and the selection of patients for such trials are proposed, taking into account the particularities of this location of OA. |
| doi_str_mv | 10.1053/joca.1999.0340 |
| format | Article |
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Although very common, hand osteoarthritis (OA) is rarely the focus of clinical trials aimed at determining whether a drug is effective on its symptoms and/or anatomical progression. Besides the common difficulties met in trials in OA in general, the highly unpredictable course of hand OA presents specific challenges. However, hand OA is beginning to be considered as a potential model for the study of drugs in OA, since researchers now have at their disposal new clinical tools and radiological methods to assess with better accuracy and sensitivity either its symptomatic activity or its anatomical course.
The now well-known consensual recommendations for the design and conduct of clinical trials in OA are reviewed, and the specific clinical tools and radiological methods available for the assessment of hand OA detailed. Some specific recommendations for the design of clinical trials in hand OA and the selection of patients for such trials are proposed, taking into account the particularities of this location of OA.</description><identifier>ISSN: 1063-4584</identifier><identifier>EISSN: 1522-9653</identifier><identifier>DOI: 10.1053/joca.1999.0340</identifier><identifier>PMID: 11156498</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Clinical trials ; Hand Deformities, Acquired - diagnosis ; Hand Deformities, Acquired - drug therapy ; Hand OA ; Humans ; Methodology ; New assessment tools ; Osteoarthritis - diagnosis ; Osteoarthritis - drug therapy ; Patient Selection ; Research Design ; Sensitivity and Specificity ; Treatment Outcome</subject><ispartof>Osteoarthritis and cartilage, 2000-01, Vol.8, p.S64-S69</ispartof><rights>2000 OsteoArthritis Research Society International</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-ef7fdd70a25886fa163e26d363cecf5b64e1dcfd42c82f2241b1f75bc06144cd3</citedby><cites>FETCH-LOGICAL-c380t-ef7fdd70a25886fa163e26d363cecf5b64e1dcfd42c82f2241b1f75bc06144cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1063458499800181$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11156498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lequesne, M.G.</creatorcontrib><creatorcontrib>Maheu, E.</creatorcontrib><title>Methodology of clinical trials in hand osteoarthritis: Conventional and proposed tools</title><title>Osteoarthritis and cartilage</title><addtitle>Osteoarthritis Cartilage</addtitle><description>Summary
Although very common, hand osteoarthritis (OA) is rarely the focus of clinical trials aimed at determining whether a drug is effective on its symptoms and/or anatomical progression. Besides the common difficulties met in trials in OA in general, the highly unpredictable course of hand OA presents specific challenges. However, hand OA is beginning to be considered as a potential model for the study of drugs in OA, since researchers now have at their disposal new clinical tools and radiological methods to assess with better accuracy and sensitivity either its symptomatic activity or its anatomical course.
The now well-known consensual recommendations for the design and conduct of clinical trials in OA are reviewed, and the specific clinical tools and radiological methods available for the assessment of hand OA detailed. Some specific recommendations for the design of clinical trials in hand OA and the selection of patients for such trials are proposed, taking into account the particularities of this location of OA.</description><subject>Clinical trials</subject><subject>Hand Deformities, Acquired - diagnosis</subject><subject>Hand Deformities, Acquired - drug therapy</subject><subject>Hand OA</subject><subject>Humans</subject><subject>Methodology</subject><subject>New assessment tools</subject><subject>Osteoarthritis - diagnosis</subject><subject>Osteoarthritis - drug therapy</subject><subject>Patient Selection</subject><subject>Research Design</subject><subject>Sensitivity and Specificity</subject><subject>Treatment Outcome</subject><issn>1063-4584</issn><issn>1522-9653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqWwMqJMbCn-bsKGKr6kIhZgtRz7TF2lcbHdSv33JGolJqa74Xnf0z0IXRM8JViwu1Uwekrqup5ixvEJGhNBaVlLwU77HUtWclHxEbpIaYUxZoTgczQihAjJ62qMvt4gL4MNbfjeF8EVpvWdN7otcvS6TYXviqXubBFShqBjXkaffbov5qHbQZd96Hp2ADYxbEICW-QQ2nSJzlwfh6vjnKDPp8eP-Uu5eH9-nT8sSsMqnEtwM2ftDGsqqko6TSQDKi2TzIBxopEciDXOcmoq6ijlpCFuJhqDJeHcWDZBt4fe_vzPFlJWa58MtK3uIGyTmlHBhCSsB6cH0MSQUgSnNtGvddwrgtVgUg0m1WBSDSb7wM2xeduswf7hR3U9UB0A6P_beYgqGQ-dAesjmKxs8P91_wK-pYQx</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Lequesne, M.G.</creator><creator>Maheu, E.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>Methodology of clinical trials in hand osteoarthritis: Conventional and proposed tools</title><author>Lequesne, M.G. ; Maheu, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-ef7fdd70a25886fa163e26d363cecf5b64e1dcfd42c82f2241b1f75bc06144cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Clinical trials</topic><topic>Hand Deformities, Acquired - diagnosis</topic><topic>Hand Deformities, Acquired - drug therapy</topic><topic>Hand OA</topic><topic>Humans</topic><topic>Methodology</topic><topic>New assessment tools</topic><topic>Osteoarthritis - diagnosis</topic><topic>Osteoarthritis - drug therapy</topic><topic>Patient Selection</topic><topic>Research Design</topic><topic>Sensitivity and Specificity</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lequesne, M.G.</creatorcontrib><creatorcontrib>Maheu, E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoarthritis and cartilage</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lequesne, M.G.</au><au>Maheu, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methodology of clinical trials in hand osteoarthritis: Conventional and proposed tools</atitle><jtitle>Osteoarthritis and cartilage</jtitle><addtitle>Osteoarthritis Cartilage</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>8</volume><spage>S64</spage><epage>S69</epage><pages>S64-S69</pages><issn>1063-4584</issn><eissn>1522-9653</eissn><abstract>Summary
Although very common, hand osteoarthritis (OA) is rarely the focus of clinical trials aimed at determining whether a drug is effective on its symptoms and/or anatomical progression. Besides the common difficulties met in trials in OA in general, the highly unpredictable course of hand OA presents specific challenges. However, hand OA is beginning to be considered as a potential model for the study of drugs in OA, since researchers now have at their disposal new clinical tools and radiological methods to assess with better accuracy and sensitivity either its symptomatic activity or its anatomical course.
The now well-known consensual recommendations for the design and conduct of clinical trials in OA are reviewed, and the specific clinical tools and radiological methods available for the assessment of hand OA detailed. Some specific recommendations for the design of clinical trials in hand OA and the selection of patients for such trials are proposed, taking into account the particularities of this location of OA.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11156498</pmid><doi>10.1053/joca.1999.0340</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Osteoarthritis and cartilage, 2000-01, Vol.8, p.S64-S69 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Clinical trials Hand Deformities, Acquired - diagnosis Hand Deformities, Acquired - drug therapy Hand OA Humans Methodology New assessment tools Osteoarthritis - diagnosis Osteoarthritis - drug therapy Patient Selection Research Design Sensitivity and Specificity Treatment Outcome |
| title | Methodology of clinical trials in hand osteoarthritis: Conventional and proposed tools |
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