Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve β-catenin and cyclin D1 down-regulation

Exisulind and its analogues are inhibitors of cyclic GMP phosphodiesterases (PDEs) that have been shown to activate and induce protein kinase G, resulting in the induction of apoptosis in colon cancer cells. These drugs also reduce β-catenin protein levels and decrease cyclin D1 mRNA levels in SW480...

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Veröffentlicht in:	Biochemical pharmacology 2002-11, Vol.64 (9), p.1325-1336
Hauptverfasser:	Li, Han, Liu, Li, David, Mary L., Whitehead, Clark M., Chen, Ming, Fetter, John R., Sperl, Gerhard J., Pamukcu, Rifat, Thompson, W.Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - metabolism Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis beta Catenin Biological and medical sciences Caspase 3 Caspases - metabolism cGMP Colon cancer Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Cyclin D1 Cyclin D1 - metabolism Cysteine Endopeptidases - metabolism Cytoskeletal Proteins - metabolism Down-Regulation Familial adenomatous polyposis General aspects Humans Medical sciences Multienzyme Complexes - metabolism Pharmacology. Drug treatments Proteasome Endopeptidase Complex Protein Biosynthesis - drug effects Signal Transduction Sulindac - analogs & derivatives Sulindac - pharmacology Sulindac sulfone Trans-Activators - metabolism Tumor Cells, Cultured Ubiquitin - metabolism
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