Caspase-8 in apoptosis: the beginning of "the end"?

Caspase-8 is a member of the cysteine proteases, which are implicated in apoptosis and cytokine processing. Like all caspases, caspase-8 is synthesized as an inactive single polypeptide chain zymogen procaspase and is activated by proteolytic cleavage, through either autoactivation after recruitment...

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Veröffentlicht in:	IUBMB life 2000-08, Vol.50 (2), p.85-90
Hauptverfasser:	Kruidering, M, Evan, G I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Apoptosis Apoptotic Protease-Activating Factor 1 Arabidopsis Proteins Caspase 8 Caspase 9 Caspases - metabolism Caspases - physiology Cytochrome c Group - metabolism Enzyme Activation Fatty Acid Desaturases - metabolism Humans Ligands Mice Mice, Knockout Proteins - metabolism
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