Angiotensin converting enzyme DD genotype is associated with hypertensive crisis
OBJECTIVEThe genetic background of hypertensive crisis is unknown. We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis. DESIGNPopulation-based case-control study. SETTINGEmergency department at a tertiary care university...
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| Veröffentlicht in: | Critical care medicine 2002-10, Vol.30 (10), p.2236-2241 |
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| creator | Sunder-Plassmann, Gere Kittler, Harald Eberle, Corinna Hirschl, Michael M Woisetschläger, Christian Derhaschnig, Ulla Laggner, Anton N Hörl, Walter H Födinger, Manuela |
| description | OBJECTIVEThe genetic background of hypertensive crisis is unknown. We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis.
DESIGNPopulation-based case-control study.
SETTINGEmergency department at a tertiary care university hospital.
PATIENTSA total of 182 patients with essential hypertension who were admitted to an emergency department for treatment of hypertensive crisis and 182 age- and sex-matched healthy individuals.
INTERVENTIONSNone.
MEASUREMENTSAnalysis of polymorphisms in genes coding for angiotensinogen (AGT 704T→C), angiotensin II receptor 1 (AGTR1 1166A→C), renin (REN 2646G→A), renin-binding protein (RENBP 61T→C), α-adducin (ADD1 1378G→T), β-2-adrenergic receptor (ADRB2 46A→G, 79C→G), and angiotensin I converting enzyme (ACE I/D) was performed by polymerase chain reaction and restriction fragment length polymorphism analysis.
MAIN RESULTSAmong patients, the ACE I/D polymorphism showed a deviation from Hardy-Weinberg equilibrium (p = .01). In controls, all polymorphisms were in the Hardy-Weinberg equilibrium. The frequency of the DD genotype was increased in patients (n = 70, 38.5%) vs. controls (n = 51; 28.0%;p = .03; odds ratio, 1.61; 95% confidence interval, 1.03–2.50), which was due to the DD genotype in 40 male patients (44%) vs. 23 in male controls (25.3%;p = .004; odds ratio, 3.48; 95% confidence interval, 1.47–8.30). There were no differences in genotype distributions among other polymorphisms.
CONCLUSIONWe demonstrate a possible association of the ACE DD genotype with hypertensive crisis in men. |
| doi_str_mv | 10.1097/00003246-200210000-00010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72526694</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72526694</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3860-93c7d5bfea87b213cc54f3fc700a0f45637444eca9cc7f1f84c19dbfc234dd443</originalsourceid><addsrcrecordid>eNp1kU1vGyEQhlGVqnGT_IWKS3LbFhjYXY5Rkn5IkdpDe0aYHWySNesw61jur-86dptTkRCa0fPOSA-McSk-SmGbT2I6oHRdKSGU3FfVdKV4w2bSwFQoCydsJoQVFWgLp-w90cNEaNPAO3YqFVhtjZixH9d5kYYRM6XMw5CfsYwpLzjm37sV8ttbvsA8jLs18kTcEw0h-RE7vk3jki-nfnkJPyMPJVGic_Y2-p7w4viesV-f737efK3uv3_5dnN9XwVoa1FZCE1n5hF928yVhBCMjhBDI4QXUZsaGq01Bm9DaKKMrQ7SdvMYFOiu0xrO2NVh7roMTxuk0a0SBex7n3HYkGuUUXVt92B7AEMZiApGty5p5cvOSeH2Nt1fm-6fTfdic4p-OO7YzFfYvQaP-ibg8gh4Cr6PxeeQ6JXTYKA1auL0gdsO_YiFHvvNFotbou_Hpfvfb8IfhpGNKA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72526694</pqid></control><display><type>article</type><title>Angiotensin converting enzyme DD genotype is associated with hypertensive crisis</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Sunder-Plassmann, Gere ; Kittler, Harald ; Eberle, Corinna ; Hirschl, Michael M ; Woisetschläger, Christian ; Derhaschnig, Ulla ; Laggner, Anton N ; Hörl, Walter H ; Födinger, Manuela</creator><creatorcontrib>Sunder-Plassmann, Gere ; Kittler, Harald ; Eberle, Corinna ; Hirschl, Michael M ; Woisetschläger, Christian ; Derhaschnig, Ulla ; Laggner, Anton N ; Hörl, Walter H ; Födinger, Manuela</creatorcontrib><description>OBJECTIVEThe genetic background of hypertensive crisis is unknown. We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis.
DESIGNPopulation-based case-control study.
SETTINGEmergency department at a tertiary care university hospital.
PATIENTSA total of 182 patients with essential hypertension who were admitted to an emergency department for treatment of hypertensive crisis and 182 age- and sex-matched healthy individuals.
INTERVENTIONSNone.
MEASUREMENTSAnalysis of polymorphisms in genes coding for angiotensinogen (AGT 704T→C), angiotensin II receptor 1 (AGTR1 1166A→C), renin (REN 2646G→A), renin-binding protein (RENBP 61T→C), α-adducin (ADD1 1378G→T), β-2-adrenergic receptor (ADRB2 46A→G, 79C→G), and angiotensin I converting enzyme (ACE I/D) was performed by polymerase chain reaction and restriction fragment length polymorphism analysis.
MAIN RESULTSAmong patients, the ACE I/D polymorphism showed a deviation from Hardy-Weinberg equilibrium (p = .01). In controls, all polymorphisms were in the Hardy-Weinberg equilibrium. The frequency of the DD genotype was increased in patients (n = 70, 38.5%) vs. controls (n = 51; 28.0%;p = .03; odds ratio, 1.61; 95% confidence interval, 1.03–2.50), which was due to the DD genotype in 40 male patients (44%) vs. 23 in male controls (25.3%;p = .004; odds ratio, 3.48; 95% confidence interval, 1.47–8.30). There were no differences in genotype distributions among other polymorphisms.
CONCLUSIONWe demonstrate a possible association of the ACE DD genotype with hypertensive crisis in men.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-200210000-00010</identifier><identifier>PMID: 12394950</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</publisher><subject>Angiotensinogen - genetics ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Calmodulin-Binding Proteins - genetics ; Carbohydrate Epimerases - genetics ; Cardiology. Vascular system ; Carrier Proteins - genetics ; Case-Control Studies ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Emergencies ; Female ; Gene Frequency ; Genotype ; Humans ; Hypertension - genetics ; Hypertension - metabolism ; Male ; Medical sciences ; Middle Aged ; Peptidyl-Dipeptidase A - genetics ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Receptor, Angiotensin, Type 1 ; Receptors, Adrenergic, beta-2 - genetics ; Receptors, Angiotensin - genetics ; Renin - genetics ; Renin-Angiotensin System - genetics</subject><ispartof>Critical care medicine, 2002-10, Vol.30 (10), p.2236-2241</ispartof><rights>2002 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3860-93c7d5bfea87b213cc54f3fc700a0f45637444eca9cc7f1f84c19dbfc234dd443</citedby><cites>FETCH-LOGICAL-c3860-93c7d5bfea87b213cc54f3fc700a0f45637444eca9cc7f1f84c19dbfc234dd443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14353852$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12394950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sunder-Plassmann, Gere</creatorcontrib><creatorcontrib>Kittler, Harald</creatorcontrib><creatorcontrib>Eberle, Corinna</creatorcontrib><creatorcontrib>Hirschl, Michael M</creatorcontrib><creatorcontrib>Woisetschläger, Christian</creatorcontrib><creatorcontrib>Derhaschnig, Ulla</creatorcontrib><creatorcontrib>Laggner, Anton N</creatorcontrib><creatorcontrib>Hörl, Walter H</creatorcontrib><creatorcontrib>Födinger, Manuela</creatorcontrib><title>Angiotensin converting enzyme DD genotype is associated with hypertensive crisis</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>OBJECTIVEThe genetic background of hypertensive crisis is unknown. We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis.
DESIGNPopulation-based case-control study.
SETTINGEmergency department at a tertiary care university hospital.
PATIENTSA total of 182 patients with essential hypertension who were admitted to an emergency department for treatment of hypertensive crisis and 182 age- and sex-matched healthy individuals.
INTERVENTIONSNone.
MEASUREMENTSAnalysis of polymorphisms in genes coding for angiotensinogen (AGT 704T→C), angiotensin II receptor 1 (AGTR1 1166A→C), renin (REN 2646G→A), renin-binding protein (RENBP 61T→C), α-adducin (ADD1 1378G→T), β-2-adrenergic receptor (ADRB2 46A→G, 79C→G), and angiotensin I converting enzyme (ACE I/D) was performed by polymerase chain reaction and restriction fragment length polymorphism analysis.
MAIN RESULTSAmong patients, the ACE I/D polymorphism showed a deviation from Hardy-Weinberg equilibrium (p = .01). In controls, all polymorphisms were in the Hardy-Weinberg equilibrium. The frequency of the DD genotype was increased in patients (n = 70, 38.5%) vs. controls (n = 51; 28.0%;p = .03; odds ratio, 1.61; 95% confidence interval, 1.03–2.50), which was due to the DD genotype in 40 male patients (44%) vs. 23 in male controls (25.3%;p = .004; odds ratio, 3.48; 95% confidence interval, 1.47–8.30). There were no differences in genotype distributions among other polymorphisms.
CONCLUSIONWe demonstrate a possible association of the ACE DD genotype with hypertensive crisis in men.</description><subject>Angiotensinogen - genetics</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Calmodulin-Binding Proteins - genetics</subject><subject>Carbohydrate Epimerases - genetics</subject><subject>Cardiology. Vascular system</subject><subject>Carrier Proteins - genetics</subject><subject>Case-Control Studies</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Emergencies</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Hypertension - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Receptor, Angiotensin, Type 1</subject><subject>Receptors, Adrenergic, beta-2 - genetics</subject><subject>Receptors, Angiotensin - genetics</subject><subject>Renin - genetics</subject><subject>Renin-Angiotensin System - genetics</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1vGyEQhlGVqnGT_IWKS3LbFhjYXY5Rkn5IkdpDe0aYHWySNesw61jur-86dptTkRCa0fPOSA-McSk-SmGbT2I6oHRdKSGU3FfVdKV4w2bSwFQoCydsJoQVFWgLp-w90cNEaNPAO3YqFVhtjZixH9d5kYYRM6XMw5CfsYwpLzjm37sV8ttbvsA8jLs18kTcEw0h-RE7vk3jki-nfnkJPyMPJVGic_Y2-p7w4viesV-f737efK3uv3_5dnN9XwVoa1FZCE1n5hF928yVhBCMjhBDI4QXUZsaGq01Bm9DaKKMrQ7SdvMYFOiu0xrO2NVh7roMTxuk0a0SBex7n3HYkGuUUXVt92B7AEMZiApGty5p5cvOSeH2Nt1fm-6fTfdic4p-OO7YzFfYvQaP-ibg8gh4Cr6PxeeQ6JXTYKA1auL0gdsO_YiFHvvNFotbou_Hpfvfb8IfhpGNKA</recordid><startdate>200210</startdate><enddate>200210</enddate><creator>Sunder-Plassmann, Gere</creator><creator>Kittler, Harald</creator><creator>Eberle, Corinna</creator><creator>Hirschl, Michael M</creator><creator>Woisetschläger, Christian</creator><creator>Derhaschnig, Ulla</creator><creator>Laggner, Anton N</creator><creator>Hörl, Walter H</creator><creator>Födinger, Manuela</creator><general>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200210</creationdate><title>Angiotensin converting enzyme DD genotype is associated with hypertensive crisis</title><author>Sunder-Plassmann, Gere ; Kittler, Harald ; Eberle, Corinna ; Hirschl, Michael M ; Woisetschläger, Christian ; Derhaschnig, Ulla ; Laggner, Anton N ; Hörl, Walter H ; Födinger, Manuela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3860-93c7d5bfea87b213cc54f3fc700a0f45637444eca9cc7f1f84c19dbfc234dd443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Angiotensinogen - genetics</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Calmodulin-Binding Proteins - genetics</topic><topic>Carbohydrate Epimerases - genetics</topic><topic>Cardiology. Vascular system</topic><topic>Carrier Proteins - genetics</topic><topic>Case-Control Studies</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Emergencies</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Hypertension - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Receptor, Angiotensin, Type 1</topic><topic>Receptors, Adrenergic, beta-2 - genetics</topic><topic>Receptors, Angiotensin - genetics</topic><topic>Renin - genetics</topic><topic>Renin-Angiotensin System - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sunder-Plassmann, Gere</creatorcontrib><creatorcontrib>Kittler, Harald</creatorcontrib><creatorcontrib>Eberle, Corinna</creatorcontrib><creatorcontrib>Hirschl, Michael M</creatorcontrib><creatorcontrib>Woisetschläger, Christian</creatorcontrib><creatorcontrib>Derhaschnig, Ulla</creatorcontrib><creatorcontrib>Laggner, Anton N</creatorcontrib><creatorcontrib>Hörl, Walter H</creatorcontrib><creatorcontrib>Födinger, Manuela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sunder-Plassmann, Gere</au><au>Kittler, Harald</au><au>Eberle, Corinna</au><au>Hirschl, Michael M</au><au>Woisetschläger, Christian</au><au>Derhaschnig, Ulla</au><au>Laggner, Anton N</au><au>Hörl, Walter H</au><au>Födinger, Manuela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin converting enzyme DD genotype is associated with hypertensive crisis</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>2002-10</date><risdate>2002</risdate><volume>30</volume><issue>10</issue><spage>2236</spage><epage>2241</epage><pages>2236-2241</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>OBJECTIVEThe genetic background of hypertensive crisis is unknown. We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis.
DESIGNPopulation-based case-control study.
SETTINGEmergency department at a tertiary care university hospital.
PATIENTSA total of 182 patients with essential hypertension who were admitted to an emergency department for treatment of hypertensive crisis and 182 age- and sex-matched healthy individuals.
INTERVENTIONSNone.
MEASUREMENTSAnalysis of polymorphisms in genes coding for angiotensinogen (AGT 704T→C), angiotensin II receptor 1 (AGTR1 1166A→C), renin (REN 2646G→A), renin-binding protein (RENBP 61T→C), α-adducin (ADD1 1378G→T), β-2-adrenergic receptor (ADRB2 46A→G, 79C→G), and angiotensin I converting enzyme (ACE I/D) was performed by polymerase chain reaction and restriction fragment length polymorphism analysis.
MAIN RESULTSAmong patients, the ACE I/D polymorphism showed a deviation from Hardy-Weinberg equilibrium (p = .01). In controls, all polymorphisms were in the Hardy-Weinberg equilibrium. The frequency of the DD genotype was increased in patients (n = 70, 38.5%) vs. controls (n = 51; 28.0%;p = .03; odds ratio, 1.61; 95% confidence interval, 1.03–2.50), which was due to the DD genotype in 40 male patients (44%) vs. 23 in male controls (25.3%;p = .004; odds ratio, 3.48; 95% confidence interval, 1.47–8.30). There were no differences in genotype distributions among other polymorphisms.
CONCLUSIONWe demonstrate a possible association of the ACE DD genotype with hypertensive crisis in men.</abstract><cop>Hagerstown, MD</cop><pub>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</pub><pmid>12394950</pmid><doi>10.1097/00003246-200210000-00010</doi><tpages>6</tpages></addata></record> |
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| subjects | Angiotensinogen - genetics Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Calmodulin-Binding Proteins - genetics Carbohydrate Epimerases - genetics Cardiology. Vascular system Carrier Proteins - genetics Case-Control Studies Clinical manifestations. Epidemiology. Investigative techniques. Etiology Emergencies Female Gene Frequency Genotype Humans Hypertension - genetics Hypertension - metabolism Male Medical sciences Middle Aged Peptidyl-Dipeptidase A - genetics Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Receptor, Angiotensin, Type 1 Receptors, Adrenergic, beta-2 - genetics Receptors, Angiotensin - genetics Renin - genetics Renin-Angiotensin System - genetics |
| title | Angiotensin converting enzyme DD genotype is associated with hypertensive crisis |
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