Clone-forming activity of embryonal stem hemopoietic cells after transplantation to newborn or adult sublethally irradiated mice
Hemopoietic activity of stem hemopoietic cells from the liver of embryos was studied at different terms of intrauterine development. The fate of individual clones of hemopoietic cells marked by human adenosine deaminase gene was followed up in sublethally irradiated or newborn recipients. The effici...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2000-07, Vol.130 (7), p.709-711 |
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| creator | Drize, N I Chertkov, I L |
| description | Hemopoietic activity of stem hemopoietic cells from the liver of embryos was studied at different terms of intrauterine development. The fate of individual clones of hemopoietic cells marked by human adenosine deaminase gene was followed up in sublethally irradiated or newborn recipients. The efficiency of marker gene incorporation in primitive stem hemopoietic cells from the liver of 12-, 13-, and 17-day embryos was not high. Gene transfer was performed without cell prestimulation to division, and hence, these data show that primitive stem cells proliferate even in 17-day embryos. Cells from embryonal liver in all terms maintain hemopoiesis both in newborn and adult microenvironment, hemopoiesis being realized according to the clonal succession model, i. e. in the some way after transplantation of the bone marrow from adult mice. |
| doi_str_mv | 10.1007/BF02682112 |
| format | Article |
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Cells from embryonal liver in all terms maintain hemopoiesis both in newborn and adult microenvironment, hemopoiesis being realized according to the clonal succession model, i. e. in the some way after transplantation of the bone marrow from adult mice.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Cesium Radioisotopes</subject><subject>Clone Cells</subject><subject>Embryo, Mammalian - cytology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Liver - cytology</subject><subject>Liver - embryology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1rGzEQhkVoiF03l_6AInrIobCpRl-7PrYmTgOBXNLzotXOJjJayZW0Db71p3dNDIHMZRjm4YWZh5DPwK6Bsfr7zy3juuEA_IwsQdWiajiHD2TJ5m0lm6ZZkI85744j03BBFgAgmVqLJfm38TFgNcQ0uvBEjS3urysHGgeKY5cOMRhPc8GRPuMY99FhcZZa9D5TMxRMtCQT8t6bUExxMdASacCXLqZAY6Kmn3yheeo8lmfj_YG6lEzvTMGejs7iJ3I-GJ_x8tRX5Pf25nHzq7p_uL3b_LivrABWqloOUJtOsF7V2mjslWass3wuzZpG1v16baDWoOTaou6k0AoV7zRyK4UUYkWuXnP3Kf6ZMJd2dPl4hwkYp9zWXHGltZzBr-_AXZzS_IbcchCScyZhhr69QjbFnBMO7T650aRDC6w9SmnfpMzwl1Pi1I3Yv6EnC-I_KpuHnw</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Drize, N I</creator><creator>Chertkov, I L</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>Clone-forming activity of embryonal stem hemopoietic cells after transplantation to newborn or adult sublethally irradiated mice</title><author>Drize, N I ; Chertkov, I L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-74f17ab30d576a6ed5600bc2222608847d99a1761549ce6b4365e52b6e2c43433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Cesium Radioisotopes</topic><topic>Clone Cells</topic><topic>Embryo, Mammalian - cytology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Liver - cytology</topic><topic>Liver - embryology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drize, N I</creatorcontrib><creatorcontrib>Chertkov, I L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drize, N I</au><au>Chertkov, I L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clone-forming activity of embryonal stem hemopoietic cells after transplantation to newborn or adult sublethally irradiated mice</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><addtitle>Bull Exp Biol Med</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>130</volume><issue>7</issue><spage>709</spage><epage>711</epage><pages>709-711</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>Hemopoietic activity of stem hemopoietic cells from the liver of embryos was studied at different terms of intrauterine development. 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| subjects | Animals Animals, Newborn Cesium Radioisotopes Clone Cells Embryo, Mammalian - cytology Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - cytology Liver - cytology Liver - embryology Mice Mice, Inbred C57BL Mice, Inbred CBA |
| title | Clone-forming activity of embryonal stem hemopoietic cells after transplantation to newborn or adult sublethally irradiated mice |
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