Ziracin, a Novel Oligosaccharide Antibiotic
Ziracin is produced by Micromonospora carbonacea1) and is highly active against Grampositive bacteria. In particular it is highly active against methicillin resistant staphylococci and vancomycin resistant enterococci. Ziracin, C70H97NO38Cl2, contains two orthoester linkages, a nitro sugar, a methyl...
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| Veröffentlicht in: | Journal of antibiotics 2000/10/25, Vol.53(10), pp.1038-1044 |
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| container_title | Journal of antibiotics |
| container_volume | 53 |
| creator | GANGULY, A. K. |
| description | Ziracin is produced by Micromonospora carbonacea1) and is highly active against Grampositive bacteria. In particular it is highly active against methicillin resistant staphylococci and vancomycin resistant enterococci. Ziracin, C70H97NO38Cl2, contains two orthoester linkages, a nitro sugar, a methylene dioxy group, two aromatic ester residues and thirty five centres of assymmetries. In this paper a brief description of the structural elucidation of ziracin is presented along with the chemical modification of the antibiotic which has led to the identification of several potent antibacterials. |
| doi_str_mv | 10.7164/antibiotics.53.1038 |
| format | Article |
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Antiparasitic agents ; Applied microbiology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Gram-Positive Bacterial Infections - drug therapy ; Gram-Positive Bacterial Infections - microbiology ; Gram-Positive Cocci - drug effects ; Humans ; Medical sciences ; Microbiology ; Micromonospora carbonacea ; Molecular Structure ; oligosaccharides ; Oligosaccharides - chemistry ; Pharmacology. 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K.</creatorcontrib><title>Ziracin, a Novel Oligosaccharide Antibiotic</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Ziracin is produced by Micromonospora carbonacea1) and is highly active against Grampositive bacteria. In particular it is highly active against methicillin resistant staphylococci and vancomycin resistant enterococci. Ziracin, C70H97NO38Cl2, contains two orthoester linkages, a nitro sugar, a methylene dioxy group, two aromatic ester residues and thirty five centres of assymmetries. In this paper a brief description of the structural elucidation of ziracin is presented along with the chemical modification of the antibiotic which has led to the identification of several potent antibacterials.</description><subject>Aminoglycosides</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics (antibacterial agents, antifungal agents)</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gram-Positive Bacterial Infections - drug therapy</subject><subject>Gram-Positive Bacterial Infections - microbiology</subject><subject>Gram-Positive Cocci - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Micromonospora carbonacea</subject><subject>Molecular Structure</subject><subject>oligosaccharides</subject><subject>Oligosaccharides - chemistry</subject><subject>Pharmacology. 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Psychology</topic><topic>Gram-Positive Bacterial Infections - drug therapy</topic><topic>Gram-Positive Bacterial Infections - microbiology</topic><topic>Gram-Positive Cocci - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Micromonospora carbonacea</topic><topic>Molecular Structure</topic><topic>oligosaccharides</topic><topic>Oligosaccharides - chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Structure-Activity Relationship</topic><topic>ziracin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GANGULY, A. K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GANGULY, A. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ziracin, a Novel Oligosaccharide Antibiotic</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>2000</date><risdate>2000</risdate><volume>53</volume><issue>10</issue><spage>1038</spage><epage>1044</epage><pages>1038-1044</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Ziracin is produced by Micromonospora carbonacea1) and is highly active against Grampositive bacteria. In particular it is highly active against methicillin resistant staphylococci and vancomycin resistant enterococci. Ziracin, C70H97NO38Cl2, contains two orthoester linkages, a nitro sugar, a methylene dioxy group, two aromatic ester residues and thirty five centres of assymmetries. 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| ispartof | The Journal of Antibiotics, 2000/10/25, Vol.53(10), pp.1038-1044 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Aminoglycosides Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Applied microbiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - microbiology Gram-Positive Cocci - drug effects Humans Medical sciences Microbiology Micromonospora carbonacea Molecular Structure oligosaccharides Oligosaccharides - chemistry Pharmacology. Drug treatments Structure-Activity Relationship ziracin |
| title | Ziracin, a Novel Oligosaccharide Antibiotic |
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