Tailoring of immunosuppression in renal and liver allograft recipients displaying donor specific T-suppressor cells
Although transplantation tolerance cannot be yet reliably achieved in humans, there is evidence that active immunosuppression contributes to the maintenance of quiescence. However, the mechanism that underlies quiescence and the precise identity of regulatory cells are not completely understood. We...
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| Veröffentlicht in: | Human immunology 2002-11, Vol.63 (11), p.1010-1018 |
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| container_title | Human immunology |
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| creator | Cortesini, Raffaello Renna-Molajoni, Elvira Cinti, Paola Pretagostini, Renzo Ho, Eric Rossi, Paola Suciu-Foca Cortesini, Nicole |
| description | Although transplantation tolerance cannot be yet reliably achieved in humans, there is evidence that active immunosuppression contributes to the maintenance of quiescence. However, the mechanism that underlies quiescence and the precise identity of regulatory cells are not completely understood. We have demonstrated that allograft recipients who remain rejection-free display allospecific T-suppressor cells (Ts). Ts express the CD8
+ CD28
– phenotype, recognize major histocompatibility complex (MHC) class I antigens, and suppress the up-regulation of costimulatory molecules induced by CD40 ligation of donor antigen presenting cells. The presence of Ts is inversely correlated with T cell alloreactivity to donor MHC peptides, alloantibody production, and rejection. Monitoring of Ts has been successfully used in our studies for tailoring immunosuppression in kidney and liver allograft recipients. |
| doi_str_mv | 10.1016/S0198-8859(02)00442-1 |
| format | Article |
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+ CD28
– phenotype, recognize major histocompatibility complex (MHC) class I antigens, and suppress the up-regulation of costimulatory molecules induced by CD40 ligation of donor antigen presenting cells. The presence of Ts is inversely correlated with T cell alloreactivity to donor MHC peptides, alloantibody production, and rejection. Monitoring of Ts has been successfully used in our studies for tailoring immunosuppression in kidney and liver allograft recipients.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/S0198-8859(02)00442-1</identifier><identifier>PMID: 12392853</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antigen-Presenting Cells - physiology ; Female ; Humans ; Immunosuppression ; Kidney Transplantation - immunology ; liver transplantation ; Liver Transplantation - immunology ; Male ; Monitoring, Immunologic ; renal transplantation ; T suppressor cells ; T-Lymphocytes, Regulatory - immunology ; Transplantation, Homologous</subject><ispartof>Human immunology, 2002-11, Vol.63 (11), p.1010-1018</ispartof><rights>2002 American Society for Histocompatibility and Immunogenetics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-217095dbfe0d77d4b1f9c196a4ab1bf8c6b11c8e79ad7199bda0b6c010e3c9b93</citedby><cites>FETCH-LOGICAL-c392t-217095dbfe0d77d4b1f9c196a4ab1bf8c6b11c8e79ad7199bda0b6c010e3c9b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0198885902004421$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12392853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cortesini, Raffaello</creatorcontrib><creatorcontrib>Renna-Molajoni, Elvira</creatorcontrib><creatorcontrib>Cinti, Paola</creatorcontrib><creatorcontrib>Pretagostini, Renzo</creatorcontrib><creatorcontrib>Ho, Eric</creatorcontrib><creatorcontrib>Rossi, Paola</creatorcontrib><creatorcontrib>Suciu-Foca Cortesini, Nicole</creatorcontrib><title>Tailoring of immunosuppression in renal and liver allograft recipients displaying donor specific T-suppressor cells</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>Although transplantation tolerance cannot be yet reliably achieved in humans, there is evidence that active immunosuppression contributes to the maintenance of quiescence. However, the mechanism that underlies quiescence and the precise identity of regulatory cells are not completely understood. We have demonstrated that allograft recipients who remain rejection-free display allospecific T-suppressor cells (Ts). Ts express the CD8
+ CD28
– phenotype, recognize major histocompatibility complex (MHC) class I antigens, and suppress the up-regulation of costimulatory molecules induced by CD40 ligation of donor antigen presenting cells. The presence of Ts is inversely correlated with T cell alloreactivity to donor MHC peptides, alloantibody production, and rejection. Monitoring of Ts has been successfully used in our studies for tailoring immunosuppression in kidney and liver allograft recipients.</description><subject>Antigen-Presenting Cells - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppression</subject><subject>Kidney Transplantation - immunology</subject><subject>liver transplantation</subject><subject>Liver Transplantation - immunology</subject><subject>Male</subject><subject>Monitoring, Immunologic</subject><subject>renal transplantation</subject><subject>T suppressor cells</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Transplantation, Homologous</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS1E1S6lHwHkEyqHwIw3ieMTQlWhSJV6YDlb_pfKyLGDnVTqt8fbXeixp5FmfvNm9B4h7xA-IWD_-SegGJph6MQlsI8AbcsafEU2OHDRIPb9a7L5j5yRN6X8BgAOvD0lZ8i2gg3ddkPKTvmQso_3NI3UT9MaU1nnObtSfIrUR5pdVIGqaGnwDy5TFUK6z2pc6sT42bu4FGp9mYN63OvYFFOmZa7D0Ru6a_7p1a5xIZS35GRUobiLYz0nv75d765umtu77z-uvt42pn63NAw5iM7q0YHl3LYaR2FQ9KpVGvU4mF4jmsFxoSxHIbRVoHsDCG5rhBbbc_LhoDvn9Gd1ZZGTL_sPVHRpLZKzjrUIL4M49Iy1glWwO4Amp1KyG-Wc_aTyo0SQ-1jkUyxy77kEJp9ikVj33h8PrHpy9nnrmEMFvhwAV_148C7LYqqxxllfTV6kTf6FE38B4mqf9Q</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Cortesini, Raffaello</creator><creator>Renna-Molajoni, Elvira</creator><creator>Cinti, Paola</creator><creator>Pretagostini, Renzo</creator><creator>Ho, Eric</creator><creator>Rossi, Paola</creator><creator>Suciu-Foca Cortesini, Nicole</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Tailoring of immunosuppression in renal and liver allograft recipients displaying donor specific T-suppressor cells</title><author>Cortesini, Raffaello ; Renna-Molajoni, Elvira ; Cinti, Paola ; Pretagostini, Renzo ; Ho, Eric ; Rossi, Paola ; Suciu-Foca Cortesini, Nicole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-217095dbfe0d77d4b1f9c196a4ab1bf8c6b11c8e79ad7199bda0b6c010e3c9b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antigen-Presenting Cells - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppression</topic><topic>Kidney Transplantation - immunology</topic><topic>liver transplantation</topic><topic>Liver Transplantation - immunology</topic><topic>Male</topic><topic>Monitoring, Immunologic</topic><topic>renal transplantation</topic><topic>T suppressor cells</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cortesini, Raffaello</creatorcontrib><creatorcontrib>Renna-Molajoni, Elvira</creatorcontrib><creatorcontrib>Cinti, Paola</creatorcontrib><creatorcontrib>Pretagostini, Renzo</creatorcontrib><creatorcontrib>Ho, Eric</creatorcontrib><creatorcontrib>Rossi, Paola</creatorcontrib><creatorcontrib>Suciu-Foca Cortesini, Nicole</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cortesini, Raffaello</au><au>Renna-Molajoni, Elvira</au><au>Cinti, Paola</au><au>Pretagostini, Renzo</au><au>Ho, Eric</au><au>Rossi, Paola</au><au>Suciu-Foca Cortesini, Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tailoring of immunosuppression in renal and liver allograft recipients displaying donor specific T-suppressor cells</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>63</volume><issue>11</issue><spage>1010</spage><epage>1018</epage><pages>1010-1018</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>Although transplantation tolerance cannot be yet reliably achieved in humans, there is evidence that active immunosuppression contributes to the maintenance of quiescence. However, the mechanism that underlies quiescence and the precise identity of regulatory cells are not completely understood. We have demonstrated that allograft recipients who remain rejection-free display allospecific T-suppressor cells (Ts). Ts express the CD8
+ CD28
– phenotype, recognize major histocompatibility complex (MHC) class I antigens, and suppress the up-regulation of costimulatory molecules induced by CD40 ligation of donor antigen presenting cells. The presence of Ts is inversely correlated with T cell alloreactivity to donor MHC peptides, alloantibody production, and rejection. Monitoring of Ts has been successfully used in our studies for tailoring immunosuppression in kidney and liver allograft recipients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12392853</pmid><doi>10.1016/S0198-8859(02)00442-1</doi><tpages>9</tpages></addata></record> |
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| subjects | Antigen-Presenting Cells - physiology Female Humans Immunosuppression Kidney Transplantation - immunology liver transplantation Liver Transplantation - immunology Male Monitoring, Immunologic renal transplantation T suppressor cells T-Lymphocytes, Regulatory - immunology Transplantation, Homologous |
| title | Tailoring of immunosuppression in renal and liver allograft recipients displaying donor specific T-suppressor cells |
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