Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72–85

In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP 72–85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynam...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-12, Vol.10 (24), p.2713-2717
Hauptverfasser:	Tselios, Theodore, Daliani, Ioanna, Deraos, Spyros, Thymianou, Soteria, Matsoukas, Elisabeth, Troganis, Anastasios, Gerothanassis, Ioannis, Mouzaki, Athanasia, Mavromoustakos, Thomas, Probert, Lesley, Matsoukas, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Drug Design Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - prevention & control Epitopes - administration & dosage Epitopes - pharmacology Experimental and animal immunopathology. Animal models Guinea Pigs Immunization Immunopathology Medical sciences Models, Molecular Myelin Basic Protein - chemical synthesis Myelin Basic Protein - immunology Myelin Basic Protein - pharmacology Nuclear Magnetic Resonance, Biomolecular Peptide Fragments - chemical synthesis Peptide Fragments - immunology Peptide Fragments - pharmacology Peptides, Cyclic - chemical synthesis Peptides, Cyclic - immunology Peptides, Cyclic - pharmacology Rats Rats, Inbred Lew Spinal Cord - drug effects Spinal Cord - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!