Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72–85
In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP 72–85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynam...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2000-12, Vol.10 (24), p.2713-2717 |
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| creator | Tselios, Theodore Daliani, Ioanna Deraos, Spyros Thymianou, Soteria Matsoukas, Elisabeth Troganis, Anastasios Gerothanassis, Ioannis Mouzaki, Athanasia Mavromoustakos, Thomas Probert, Lesley Matsoukas, John |
| description | In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP
72–85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Ala
81MBP
72–85. The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with linear and cyclic agonist analogues MBP
72–85 and cyclo(2–9)MBP
72–85. |
| doi_str_mv | 10.1016/S0960-894X(00)00556-4 |
| format | Article |
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72–85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Ala
81MBP
72–85. The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with linear and cyclic agonist analogues MBP
72–85 and cyclo(2–9)MBP
72–85.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/S0960-894X(00)00556-4</identifier><identifier>PMID: 11133075</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Drug Design ; Encephalomyelitis, Autoimmune, Experimental - drug therapy ; Encephalomyelitis, Autoimmune, Experimental - pathology ; Encephalomyelitis, Autoimmune, Experimental - prevention & control ; Epitopes - administration & dosage ; Epitopes - pharmacology ; Experimental and animal immunopathology. Animal models ; Guinea Pigs ; Immunization ; Immunopathology ; Medical sciences ; Models, Molecular ; Myelin Basic Protein - chemical synthesis ; Myelin Basic Protein - immunology ; Myelin Basic Protein - pharmacology ; Nuclear Magnetic Resonance, Biomolecular ; Peptide Fragments - chemical synthesis ; Peptide Fragments - immunology ; Peptide Fragments - pharmacology ; Peptides, Cyclic - chemical synthesis ; Peptides, Cyclic - immunology ; Peptides, Cyclic - pharmacology ; Rats ; Rats, Inbred Lew ; Spinal Cord - drug effects ; Spinal Cord - pathology</subject><ispartof>Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (24), p.2713-2717</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-c1bb82f9bf9e116dde6d29b88524915fff92aa14a3fb1facb7c3612ef3712f053</citedby><cites>FETCH-LOGICAL-c389t-c1bb82f9bf9e116dde6d29b88524915fff92aa14a3fb1facb7c3612ef3712f053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0960-894X(00)00556-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=825700$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11133075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tselios, Theodore</creatorcontrib><creatorcontrib>Daliani, Ioanna</creatorcontrib><creatorcontrib>Deraos, Spyros</creatorcontrib><creatorcontrib>Thymianou, Soteria</creatorcontrib><creatorcontrib>Matsoukas, Elisabeth</creatorcontrib><creatorcontrib>Troganis, Anastasios</creatorcontrib><creatorcontrib>Gerothanassis, Ioannis</creatorcontrib><creatorcontrib>Mouzaki, Athanasia</creatorcontrib><creatorcontrib>Mavromoustakos, Thomas</creatorcontrib><creatorcontrib>Probert, Lesley</creatorcontrib><creatorcontrib>Matsoukas, John</creatorcontrib><title>Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72–85</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP
72–85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Ala
81MBP
72–85. The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with linear and cyclic agonist analogues MBP
72–85 and cyclo(2–9)MBP
72–85.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Drug Design</subject><subject>Encephalomyelitis, Autoimmune, Experimental - drug therapy</subject><subject>Encephalomyelitis, Autoimmune, Experimental - pathology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - prevention & control</subject><subject>Epitopes - administration & dosage</subject><subject>Epitopes - pharmacology</subject><subject>Experimental and animal immunopathology. Animal models</subject><subject>Guinea Pigs</subject><subject>Immunization</subject><subject>Immunopathology</subject><subject>Medical sciences</subject><subject>Models, Molecular</subject><subject>Myelin Basic Protein - chemical synthesis</subject><subject>Myelin Basic Protein - immunology</subject><subject>Myelin Basic Protein - pharmacology</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Peptide Fragments - chemical synthesis</subject><subject>Peptide Fragments - immunology</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptides, Cyclic - chemical synthesis</subject><subject>Peptides, Cyclic - immunology</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - pathology</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd2KFDEQhYMo7rj6CEpAkJmL1ko6SXdfybqMP7Ci4ArehXS6MkYy3b1Jj9h3voL4hj6JmR_WS6-KqnynUpxDyGMGzxkw9eITNAqKuhFflgArAClVIe6QBRNKFKUAeZcsbpEz8iClbwBMgBD3yRljrCyhkgvy6zqimbbYT3RwFH-MGP2-M4GaEDBuvKXYWxy_mjBsZwx-8oku1xfrFW1namg0kx_6zM60w-Q3PXbUzjZkncnjYbPD_eaDtKetSflhjMOEuVu-f_VxRXH00zAirfifn79r-ZDccyYkfHSq5-Tz6_X15dvi6sObd5cXV4Ut62YqLGvbmrumdQ0yproOVcebtq4lFw2TzrmGG8OEKV3LnLFtZUvFOLqyYtyBLM_Js-PefM3NDtOktz5ZDMH0OOySrrjkpVIqg_II2jikFNHpMXtk4qwZ6H0W-pCF3hutAfQhCy2y7snpg127xe6f6mR-Bp6eAJOsCS6a3vp0y9VcVgCZenmkMJvx3WPUyfp9JJ2PaCfdDf4_h_wFAxeoYQ</recordid><startdate>20001218</startdate><enddate>20001218</enddate><creator>Tselios, Theodore</creator><creator>Daliani, Ioanna</creator><creator>Deraos, Spyros</creator><creator>Thymianou, Soteria</creator><creator>Matsoukas, Elisabeth</creator><creator>Troganis, Anastasios</creator><creator>Gerothanassis, Ioannis</creator><creator>Mouzaki, Athanasia</creator><creator>Mavromoustakos, Thomas</creator><creator>Probert, Lesley</creator><creator>Matsoukas, John</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001218</creationdate><title>Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72–85</title><author>Tselios, Theodore ; Daliani, Ioanna ; Deraos, Spyros ; Thymianou, Soteria ; Matsoukas, Elisabeth ; Troganis, Anastasios ; Gerothanassis, Ioannis ; Mouzaki, Athanasia ; Mavromoustakos, Thomas ; Probert, Lesley ; Matsoukas, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-c1bb82f9bf9e116dde6d29b88524915fff92aa14a3fb1facb7c3612ef3712f053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Drug Design</topic><topic>Encephalomyelitis, Autoimmune, Experimental - drug therapy</topic><topic>Encephalomyelitis, Autoimmune, Experimental - pathology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - prevention & control</topic><topic>Epitopes - administration & dosage</topic><topic>Epitopes - pharmacology</topic><topic>Experimental and animal immunopathology. Animal models</topic><topic>Guinea Pigs</topic><topic>Immunization</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><topic>Models, Molecular</topic><topic>Myelin Basic Protein - chemical synthesis</topic><topic>Myelin Basic Protein - immunology</topic><topic>Myelin Basic Protein - pharmacology</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Peptide Fragments - chemical synthesis</topic><topic>Peptide Fragments - immunology</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peptides, Cyclic - chemical synthesis</topic><topic>Peptides, Cyclic - immunology</topic><topic>Peptides, Cyclic - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tselios, Theodore</creatorcontrib><creatorcontrib>Daliani, Ioanna</creatorcontrib><creatorcontrib>Deraos, Spyros</creatorcontrib><creatorcontrib>Thymianou, Soteria</creatorcontrib><creatorcontrib>Matsoukas, Elisabeth</creatorcontrib><creatorcontrib>Troganis, Anastasios</creatorcontrib><creatorcontrib>Gerothanassis, Ioannis</creatorcontrib><creatorcontrib>Mouzaki, Athanasia</creatorcontrib><creatorcontrib>Mavromoustakos, Thomas</creatorcontrib><creatorcontrib>Probert, Lesley</creatorcontrib><creatorcontrib>Matsoukas, John</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tselios, Theodore</au><au>Daliani, Ioanna</au><au>Deraos, Spyros</au><au>Thymianou, Soteria</au><au>Matsoukas, Elisabeth</au><au>Troganis, Anastasios</au><au>Gerothanassis, Ioannis</au><au>Mouzaki, Athanasia</au><au>Mavromoustakos, Thomas</au><au>Probert, Lesley</au><au>Matsoukas, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72–85</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2000-12-18</date><risdate>2000</risdate><volume>10</volume><issue>24</issue><spage>2713</spage><epage>2717</epage><pages>2713-2717</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP
72–85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Ala
81MBP
72–85. The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with linear and cyclic agonist analogues MBP
72–85 and cyclo(2–9)MBP
72–85.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11133075</pmid><doi>10.1016/S0960-894X(00)00556-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (24), p.2713-2717 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Drug Design Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - prevention & control Epitopes - administration & dosage Epitopes - pharmacology Experimental and animal immunopathology. Animal models Guinea Pigs Immunization Immunopathology Medical sciences Models, Molecular Myelin Basic Protein - chemical synthesis Myelin Basic Protein - immunology Myelin Basic Protein - pharmacology Nuclear Magnetic Resonance, Biomolecular Peptide Fragments - chemical synthesis Peptide Fragments - immunology Peptide Fragments - pharmacology Peptides, Cyclic - chemical synthesis Peptides, Cyclic - immunology Peptides, Cyclic - pharmacology Rats Rats, Inbred Lew Spinal Cord - drug effects Spinal Cord - pathology |
| title | Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72–85 |
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