The major cell surface glycoprotein procyclin is a receptor for induction of a novel form of cell death in African trypanosomes in vitro

Bloodstream forms (BSF) and procyclic culture forms (PCF) of African trypanosomes were incubated with a variety of lectins in vitro. Cessation of cell division and profound morphological changes were seen in procyclic forms but not in BSF after incubation with concanavalin A (Con A), wheat germ aggl...

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Veröffentlicht in:	Molecular and biochemical parasitology 2000-12, Vol.111 (2), p.333-349
Hauptverfasser:	Pearson, Terry W, Beecroft, Robert P, Welburn, Susan C, Ruepp, Stefan, Roditi, Isabel, Hwa, Kuo-Yuan, Englund, Paul T, Wells, Clive W, Murphy, Noel B
Format:	Artikel
Sprache:	eng
Schlagworte:	African trypanosomes Animals Antibodies, Monoclonal - immunology Cell death Cell Death - physiology Concanavalin A Concanavalin A - metabolism Culture Media Flow Cytometry Glycoprotein Lectin Lectins - metabolism Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Microscopy, Electron Procyclics Procyclin Protozoan Proteins Receptor Receptors, Cell Surface - metabolism Trypanosoma Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - physiology Trypanosoma congolense - genetics Trypanosoma congolense - physiology Tunicamycin - pharmacology
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