Histatin 5 inhibits inflammatory cytokine induction from human gingival fibroblasts by Porphyromonas gingivalis
Porphyromonas gingivalis is a gram‐negative rod associated with the progression of human periodontal disease. It has been demonstrated that outer‐membrane proteins as well as lipopolysaccharides from P. gingivalis ATCC 53977 can induce interleukin 6 (IL‐6) and IL‐8 from the cells of the periodontium...
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| Veröffentlicht in: | Oral microbiology and immunology 2000-12, Vol.15 (6), p.378-382 |
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| creator | Imatani, T. Kato, T. Minaguchi, K. Okuda, K. |
| description | Porphyromonas gingivalis is a gram‐negative rod associated with the progression of human periodontal disease. It has been demonstrated that outer‐membrane proteins as well as lipopolysaccharides from P. gingivalis ATCC 53977 can induce interleukin 6 (IL‐6) and IL‐8 from the cells of the periodontium in vitro. But, they cannot induce IL‐1 and tumor necrosis factor‐α from the cells. In the present study, we studied the effects of salivary protein on cytokine induction from human gingival fibroblasts by P. gingivalis outer‐membrane protein. Histatin 5 suppressed the IL‐6 and IL‐8 induction by P. gingivalis outer‐membrane protein. This activity was more effective when outer‐membrane protein was incubated with histatin 5 before addition to the cell culture. The present study indicates that histatin 5 restrains induction of inflammatory cytokines by periodontal pathogens and that histatin is one of the salivary proteins responsible for this activity. |
| doi_str_mv | 10.1034/j.1399-302x.2000.150607.x |
| format | Article |
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It has been demonstrated that outer‐membrane proteins as well as lipopolysaccharides from P. gingivalis ATCC 53977 can induce interleukin 6 (IL‐6) and IL‐8 from the cells of the periodontium in vitro. But, they cannot induce IL‐1 and tumor necrosis factor‐α from the cells. In the present study, we studied the effects of salivary protein on cytokine induction from human gingival fibroblasts by P. gingivalis outer‐membrane protein. Histatin 5 suppressed the IL‐6 and IL‐8 induction by P. gingivalis outer‐membrane protein. This activity was more effective when outer‐membrane protein was incubated with histatin 5 before addition to the cell culture. 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Psychology ; Gingiva - cytology ; Gingiva - metabolism ; Gingiva - microbiology ; histatin 5 ; Histatins ; Humans ; inflammatory cytokine ; inhibition ; Interleukin-6 - biosynthesis ; Interleukin-8 - biosynthesis ; Lipopolysaccharides ; Microbiology ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Porphyromonas gingivalis ; Porphyromonas gingivalis - drug effects ; Porphyromonas gingivalis - pathogenicity ; Porphyromonas gingivalis - physiology ; Salivary Proteins and Peptides - pharmacology ; Salivary Proteins and Peptides - physiology</subject><ispartof>Oral microbiology and immunology, 2000-12, Vol.15 (6), p.378-382</ispartof><rights>2001 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5337-f9af121ffdcb0994edf675a1cd362fc357afea002a1ee8e6ee7aa3732dedfd043</citedby><cites>FETCH-LOGICAL-c5337-f9af121ffdcb0994edf675a1cd362fc357afea002a1ee8e6ee7aa3732dedfd043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1399-302x.2000.150607.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1399-302x.2000.150607.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=808347$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11154435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imatani, T.</creatorcontrib><creatorcontrib>Kato, T.</creatorcontrib><creatorcontrib>Minaguchi, K.</creatorcontrib><creatorcontrib>Okuda, K.</creatorcontrib><title>Histatin 5 inhibits inflammatory cytokine induction from human gingival fibroblasts by Porphyromonas gingivalis</title><title>Oral microbiology and immunology</title><addtitle>Oral Microbiol Immunol</addtitle><description>Porphyromonas gingivalis is a gram‐negative rod associated with the progression of human periodontal disease. It has been demonstrated that outer‐membrane proteins as well as lipopolysaccharides from P. gingivalis ATCC 53977 can induce interleukin 6 (IL‐6) and IL‐8 from the cells of the periodontium in vitro. But, they cannot induce IL‐1 and tumor necrosis factor‐α from the cells. In the present study, we studied the effects of salivary protein on cytokine induction from human gingival fibroblasts by P. gingivalis outer‐membrane protein. Histatin 5 suppressed the IL‐6 and IL‐8 induction by P. gingivalis outer‐membrane protein. This activity was more effective when outer‐membrane protein was incubated with histatin 5 before addition to the cell culture. The present study indicates that histatin 5 restrains induction of inflammatory cytokines by periodontal pathogens and that histatin is one of the salivary proteins responsible for this activity.</description><subject>Bacterial Outer Membrane Proteins - physiology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cytokines - biosynthesis</subject><subject>Dentistry</subject><subject>Fibroblasts - metabolism</subject><subject>Fibroblasts - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gingiva - cytology</subject><subject>Gingiva - metabolism</subject><subject>Gingiva - microbiology</subject><subject>histatin 5</subject><subject>Histatins</subject><subject>Humans</subject><subject>inflammatory cytokine</subject><subject>inhibition</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Interleukin-8 - biosynthesis</subject><subject>Lipopolysaccharides</subject><subject>Microbiology</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Porphyromonas gingivalis</subject><subject>Porphyromonas gingivalis - drug effects</subject><subject>Porphyromonas gingivalis - pathogenicity</subject><subject>Porphyromonas gingivalis - physiology</subject><subject>Salivary Proteins and Peptides - pharmacology</subject><subject>Salivary Proteins and Peptides - physiology</subject><issn>0902-0055</issn><issn>1399-302X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi1ERZeWv4CCkLhl6484Xt9ALXQrtbSV-BIXa-LYXW-TeLET2Px7vMqyHOHk0fiZd6R5EHpF8JxgVpyt54RJmTNMt3OKcepyXGIx3z5Bsz8_356iGZaY5hhzfoyex7hOJC-lfIaOCSG8KBifIb90sYfedRnPXLdyletjKmwDbQu9D2Omx94_us6kbj3o3vkus8G32WpoocseXPfgfkKTWVcFXzUQ03w1Znc-bFZj4nwH8UC5eIqOLDTRvNi_J-jzh_efzpf59e3l1fm761xzxkRuJVhCibW1rrCUhaltKTgQXbOSWs24AGsAYwrEmIUpjREATDBaJ7LGBTtBb6bcTfA_BhN71bqoTdNAZ_wQlaCc0lLIf4JECFomOIFyAnXwMQZj1Sa4FsKoCFY7LWqtdsdXOy1qp0VNWtQ2zb7cLxmq1tR_J_ceEvB6D0DU0NgAnXbxwC3wghUiUW8n6pdrzPj_-9XtzdVUp4h8ikjazfYQAeFRlYIJrr5-vFQ3_MvF_Xd6p5bsN-iHvJM</recordid><startdate>200012</startdate><enddate>200012</enddate><creator>Imatani, T.</creator><creator>Kato, T.</creator><creator>Minaguchi, K.</creator><creator>Okuda, K.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200012</creationdate><title>Histatin 5 inhibits inflammatory cytokine induction from human gingival fibroblasts by Porphyromonas gingivalis</title><author>Imatani, T. ; Kato, T. ; Minaguchi, K. ; Okuda, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5337-f9af121ffdcb0994edf675a1cd362fc357afea002a1ee8e6ee7aa3732dedfd043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Bacterial Outer Membrane Proteins - physiology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Cytokines - biosynthesis</topic><topic>Dentistry</topic><topic>Fibroblasts - metabolism</topic><topic>Fibroblasts - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gingiva - cytology</topic><topic>Gingiva - metabolism</topic><topic>Gingiva - microbiology</topic><topic>histatin 5</topic><topic>Histatins</topic><topic>Humans</topic><topic>inflammatory cytokine</topic><topic>inhibition</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Interleukin-8 - biosynthesis</topic><topic>Lipopolysaccharides</topic><topic>Microbiology</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Porphyromonas gingivalis</topic><topic>Porphyromonas gingivalis - drug effects</topic><topic>Porphyromonas gingivalis - pathogenicity</topic><topic>Porphyromonas gingivalis - physiology</topic><topic>Salivary Proteins and Peptides - pharmacology</topic><topic>Salivary Proteins and Peptides - physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Imatani, T.</creatorcontrib><creatorcontrib>Kato, T.</creatorcontrib><creatorcontrib>Minaguchi, K.</creatorcontrib><creatorcontrib>Okuda, K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Oral microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imatani, T.</au><au>Kato, T.</au><au>Minaguchi, K.</au><au>Okuda, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histatin 5 inhibits inflammatory cytokine induction from human gingival fibroblasts by Porphyromonas gingivalis</atitle><jtitle>Oral microbiology and immunology</jtitle><addtitle>Oral Microbiol Immunol</addtitle><date>2000-12</date><risdate>2000</risdate><volume>15</volume><issue>6</issue><spage>378</spage><epage>382</epage><pages>378-382</pages><issn>0902-0055</issn><eissn>1399-302X</eissn><coden>OMIMEE</coden><abstract>Porphyromonas gingivalis is a gram‐negative rod associated with the progression of human periodontal disease. It has been demonstrated that outer‐membrane proteins as well as lipopolysaccharides from P. gingivalis ATCC 53977 can induce interleukin 6 (IL‐6) and IL‐8 from the cells of the periodontium in vitro. But, they cannot induce IL‐1 and tumor necrosis factor‐α from the cells. In the present study, we studied the effects of salivary protein on cytokine induction from human gingival fibroblasts by P. gingivalis outer‐membrane protein. Histatin 5 suppressed the IL‐6 and IL‐8 induction by P. gingivalis outer‐membrane protein. This activity was more effective when outer‐membrane protein was incubated with histatin 5 before addition to the cell culture. 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| subjects | Bacterial Outer Membrane Proteins - physiology Bacteriology Biological and medical sciences Cytokines - biosynthesis Dentistry Fibroblasts - metabolism Fibroblasts - microbiology Fundamental and applied biological sciences. Psychology Gingiva - cytology Gingiva - metabolism Gingiva - microbiology histatin 5 Histatins Humans inflammatory cytokine inhibition Interleukin-6 - biosynthesis Interleukin-8 - biosynthesis Lipopolysaccharides Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Porphyromonas gingivalis Porphyromonas gingivalis - drug effects Porphyromonas gingivalis - pathogenicity Porphyromonas gingivalis - physiology Salivary Proteins and Peptides - pharmacology Salivary Proteins and Peptides - physiology |
| title | Histatin 5 inhibits inflammatory cytokine induction from human gingival fibroblasts by Porphyromonas gingivalis |
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