Syntheses and Relaxation Properties of Mixed Gadolinium Hydroxypyridinonate MRI Contrast Agents

The tripodal ligand tris[(3-hydroxy-1-methyl-2-oxo-1,2-didehydropyridine-4-carboxamido)ethyl]amine (TREN-Me-3,2-HOPO) forms a stable Gd3+ complex that is a promising candidate as a magnetic resonance imaging (MRI) contrast agent. However, its low water solubility prevents detailed magnetic character...

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Veröffentlicht in:	Inorganic chemistry 2000-12, Vol.39 (25), p.5747-5756
Hauptverfasser:	Cohen, Seth M, Xu, Jide, Radkov, Emil, Raymond, Kenneth N, Botta, Mauro, Barge, Alessandro, Aime, Silvio
Format:	Artikel
Sprache:	eng
Schlagworte:	Contrast Media - chemical synthesis Contrast Media - chemistry Crystallography, X-Ray Gadolinium Indicators and Reagents Iron Chelating Agents - chemistry Magnetic Resonance Imaging Models, Molecular Molecular Conformation Molecular Structure Pyridones - chemistry Spectrophotometry, Ultraviolet
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