Effects of calcium antagonists on serotonin-dependent aggregation and serotonin transport in platelets of patients with migraine
Flunarizine and cinnarizine (IC50 6.8x10(-6) and 2.8x10(-5) M, respectively) inhibited 3H-serotonin uptake by platelets. In higher doses, they blocked serotonin-induced platelet aggregation and stimulated 3H-serotonin release from these cells. Imipramine did not affect serotonin-releasing effects of...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2000-07, Vol.130 (7), p.633-635 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Pukhal'skaya, T G Kolosova, O A Men'shikov, M Y Vein, A M |
| description | Flunarizine and cinnarizine (IC50 6.8x10(-6) and 2.8x10(-5) M, respectively) inhibited 3H-serotonin uptake by platelets. In higher doses, they blocked serotonin-induced platelet aggregation and stimulated 3H-serotonin release from these cells. Imipramine did not affect serotonin-releasing effects of preparations. In all patients cinnarizine was more potent in inhibiting serotonin uptake, and in half of the patients cinnarizine displayed higher activity as an inductor of serotonin release. |
| doi_str_mv | 10.1007/bf02682090 |
| format | Article |
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| ispartof | Bulletin of experimental biology and medicine, 2000-07, Vol.130 (7), p.633-635 |
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| subjects | Biological Transport Calcium Channel Blockers - pharmacology Cinnarizine - pharmacology Flunarizine - pharmacology Humans Male Migraine Disorders - blood Platelet Aggregation - drug effects Serotonin - metabolism Serotonin - physiology |
| title | Effects of calcium antagonists on serotonin-dependent aggregation and serotonin transport in platelets of patients with migraine |
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