Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel

Solid Lipid Nanospheres (SLN) are colloidal therapeutic systems proposed for several administration routes and obtained by dispersing warm microemulsions in cold water. SLN as carriers of doxorubicin and paclitaxel have been previously studied. In this study, the cellular uptake of SLN and the cytot...

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Veröffentlicht in:	International journal of pharmaceutics 2000-12, Vol.210 (1), p.61-67
Hauptverfasser:	Miglietta, Antonella, Cavalli, Roberta, Bocca, Claudia, Gabriel, Ludovica, Rosa Gasco, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Antineoplastic Agents, Phytogenic - metabolism Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Cell Survival - drug effects Cellular uptake Chemistry, Pharmaceutical Chemotherapy Cytotoxicity Doxorubicin - metabolism Doxorubicin - pharmacology Doxorubicin-loaded solid lipid nanospheres Fluorescent Dyes General pharmacology HL-60 Cells Humans Medical sciences Microscopy, Fluorescence Microspheres Paclitaxel - metabolism Paclitaxel - pharmacology Paclitaxel-loaded solid lipid nanospheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Tumor Cells, Cultured
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