Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice

Transplantable tumors and cell lines have been developed from pheochromocytomas arising in mice with a heterozygous knockout mutation of the neurofibromatosis gene, Nf1. Nf1 encodes a ras-GTPase-activating protein, neurofibromin, and mouse pheochromocytoma (MPC) cells in primary cultures typically s...

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Veröffentlicht in:	Cell and tissue research 2000-12, Vol.302 (3), p.309-320
Hauptverfasser:	Powers, J F, Evinger, M J, Tsokas, P, Bedri, S, Alroy, J, Shahsavari, M, Tischler, A S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - genetics Adrenal Gland Neoplasms - metabolism Adrenal Gland Neoplasms - pathology Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors Cells, Cultured DNA-Binding Proteins - metabolism Female Gene Expression Genes, Neurofibromatosis 1 Genes, Reporter Heterozygote Male Mice Mice, Knockout Neoplasm Transplantation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurofibromin 1 Nuclear Proteins - metabolism Phenylethanolamine N-Methyltransferase - genetics Phenylethanolamine N-Methyltransferase - metabolism Pheochromocytoma - genetics Pheochromocytoma - metabolism Pheochromocytoma - pathology Promoter Regions, Genetic Receptor, trkA - metabolism Reserpine - pharmacology RNA, Messenger - biosynthesis Transcription Factors Transfection Tumor Cells, Cultured
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