Effects of a 1 per cent hydrocortisone conditioner on the prevention of immediate and late‐phase reactions in canine skin

Ten laboratory beagles were used to determine whether a 1 per cent hydrocortisone conditioner applied topically for three consecutive days would inhibit IgE‐mediated immediate and late‐phase reactions induced in their skin. The trial was blinded, controlled with the product's vehicle and design...

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Veröffentlicht in:Veterinary record 2000-12, Vol.147 (26), p.739-742
Hauptverfasser: Rivierre, C., Dunston, S. M., Olivry, T.
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creator Rivierre, C.
Dunston, S. M.
Olivry, T.
description Ten laboratory beagles were used to determine whether a 1 per cent hydrocortisone conditioner applied topically for three consecutive days would inhibit IgE‐mediated immediate and late‐phase reactions induced in their skin. The trial was blinded, controlled with the product's vehicle and designed with a crossover. It consisted of three phases: one period without treatment (control phase) and two periods of treatment with either the active ingredient or the vehicle. Immediate and late‐phase reactions were induced by the intradermal injection of rabbit anti‐canine IgE polyclonal antibodies. Twenty minutes after the intradermal challenge, the diameter of the wheal, but not the erythematous flares, were significantly reduced after the application of the active product. In contrast, IgE‐mediated cutaneous late‐phase reactions, evaluated by measurements of dermal thickness and eosinophil counts six hours after challenge and the numbers of dermal CD3‐positive T lymphocytes after 24 hours, were not reduced by its application.
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source MEDLINE; Wiley Journals
subjects Administration, Cutaneous
Administration, Topical
Animals
Anti-Inflammatory Agents - administration & dosage
Cross-Over Studies
Dermatitis, Allergic Contact - immunology
Dermatitis, Allergic Contact - prevention & control
Dermatitis, Allergic Contact - veterinary
Dog Diseases - immunology
Dog Diseases - prevention & control
Dogs
Hydrocortisone
Hypersensitivity, Immediate - immunology
Hypersensitivity, Immediate - prevention & control
Hypersensitivity, Immediate - veterinary
Single-Blind Method
Skin Tests - veterinary
Treatment Outcome
title Effects of a 1 per cent hydrocortisone conditioner on the prevention of immediate and late‐phase reactions in canine skin
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