Decreased Sensitivity of 5-HT1D Receptors in Chronic Tension-Type Headache
Objective.—To assess the sensitivity of 5‐HT1D receptors in chronic tension‐type headache using sumatriptan as a pharmacological probe. Background.—Previous studies have suggested involvement of serotonergic systems in chronic tension‐type headache (CTTH), but relevant experimental data are limited....
Gespeichert in:
| Veröffentlicht in: | Headache 2002-09, Vol.42 (8), p.709-714 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 714 |
|---|---|
| container_issue | 8 |
| container_start_page | 709 |
| container_title | Headache |
| container_volume | 42 |
| creator | Rainero, I. Valfrè, W. Savi, L. Ferrero, M. Del Rizzo, P. Limone, P. Isaia, G.C. Gianotti, L. Pollo, A. Verde, R. Benedetti, F. Pinessi, L. |
| description | Objective.—To assess the sensitivity of 5‐HT1D receptors in chronic tension‐type headache using sumatriptan as a pharmacological probe.
Background.—Previous studies have suggested involvement of serotonergic systems in chronic tension‐type headache (CTTH), but relevant experimental data are limited. Sumatriptan, a 5‐HT1B/1D receptor agonist, stimulates the release of growth hormone (GH) and inhibits the release of ACTH, cortisol, and prolactin. These effects may be used to explore the function of serotonergic systems in vivo.
Methods.—We measured GH, ACTH, cortisol and prolactin (PRL) plasma concentrations in 15 patients with chronic tension‐type headache and in 18 healthy controls after subcutaneous administration of sumatriptan (6 mg) or placebo.
Results.—Placebo administration had no effect on hormone concentrations. GH and PRL secretion after sumatriptan administration was significantly (P |
| doi_str_mv | 10.1046/j.1526-4610.2002.02172.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72517896</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72517896</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3322-8afa06fca3ef8555624c58458adc443e8565ade9fdbd90e2d8bc13607737bd1b3</originalsourceid><addsrcrecordid>eNpFkVtP20AQhVeoCFLgL1T70r453Yv34pdKNAHCRSDAqI-r9e5YbOrYwevQ5N_XJgGeZjTzzZHOHIQwJWNKUvlzPqaCySSV_YARwsaEUcXG6z00-lh8QSNCqEq0SvUh-hrjnJD-NpMH6JAynhHJ-QhdTcG1YCN4_Ah1DF14Dd0GNyUWySynU_wADpZd00Ycajx5bps6OJwPaFMn-WYJeAbWW_cMx2i_tFWEk109Qk_nZ_lkltzcXVxOTm-SwDljibalJbJ0lkOphRCSpU7oVGjrXZpy0EIK6yErfeEzAszrwlEuiVJcFZ4W_Aj92Oou2-ZlBbEzixAdVJWtoVlFo5igSmeyB7_twFWxAG-WbVjYdmPe3ffA9x1go7NV2drahfjJpTSjRIme-7Xl_oUKNp97YoY0zNwMTzfD082QhnlLw6zN7Ox0OrS9QLIVCLGD9YeAbf8a2dsS5s_thfnNrx8fZH5vJvw_lEuLAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72517896</pqid></control><display><type>article</type><title>Decreased Sensitivity of 5-HT1D Receptors in Chronic Tension-Type Headache</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Rainero, I. ; Valfrè, W. ; Savi, L. ; Ferrero, M. ; Del Rizzo, P. ; Limone, P. ; Isaia, G.C. ; Gianotti, L. ; Pollo, A. ; Verde, R. ; Benedetti, F. ; Pinessi, L.</creator><creatorcontrib>Rainero, I. ; Valfrè, W. ; Savi, L. ; Ferrero, M. ; Del Rizzo, P. ; Limone, P. ; Isaia, G.C. ; Gianotti, L. ; Pollo, A. ; Verde, R. ; Benedetti, F. ; Pinessi, L.</creatorcontrib><description>Objective.—To assess the sensitivity of 5‐HT1D receptors in chronic tension‐type headache using sumatriptan as a pharmacological probe.
Background.—Previous studies have suggested involvement of serotonergic systems in chronic tension‐type headache (CTTH), but relevant experimental data are limited. Sumatriptan, a 5‐HT1B/1D receptor agonist, stimulates the release of growth hormone (GH) and inhibits the release of ACTH, cortisol, and prolactin. These effects may be used to explore the function of serotonergic systems in vivo.
Methods.—We measured GH, ACTH, cortisol and prolactin (PRL) plasma concentrations in 15 patients with chronic tension‐type headache and in 18 healthy controls after subcutaneous administration of sumatriptan (6 mg) or placebo.
Results.—Placebo administration had no effect on hormone concentrations. GH and PRL secretion after sumatriptan administration was significantly (P<0.01 and <0.05) altered in CTTH patients in comparison with controls.
Conclusion.—Our results suggest that cerebral serotonergic functions mediated by 5‐HT1D receptors are altered in CTTH.</description><identifier>ISSN: 0017-8748</identifier><identifier>EISSN: 1526-4610</identifier><identifier>DOI: 10.1046/j.1526-4610.2002.02172.x</identifier><identifier>PMID: 12390633</identifier><identifier>CODEN: HEADAE</identifier><language>eng</language><publisher>Boston, MA, USA: Blackwell Science Inc</publisher><subject>5-HT1D receptors ; Adult ; Biological and medical sciences ; Brain - metabolism ; Chronic Disease ; chronic tension-type headache ; Female ; Growth Hormone - blood ; Growth Hormone - drug effects ; Growth Hormone - metabolism ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Prolactin - drug effects ; Prolactin - metabolism ; Receptor, Serotonin, 5-HT1D ; Receptors, Serotonin - drug effects ; Receptors, Serotonin - metabolism ; Serotonin Receptor Agonists - metabolism ; Serotonin Receptor Agonists - pharmacology ; sumatriptan ; Sumatriptan - metabolism ; Sumatriptan - pharmacology ; Tension-Type Headache - metabolism</subject><ispartof>Headache, 2002-09, Vol.42 (8), p.709-714</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1526-4610.2002.02172.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1526-4610.2002.02172.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14191075$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12390633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rainero, I.</creatorcontrib><creatorcontrib>Valfrè, W.</creatorcontrib><creatorcontrib>Savi, L.</creatorcontrib><creatorcontrib>Ferrero, M.</creatorcontrib><creatorcontrib>Del Rizzo, P.</creatorcontrib><creatorcontrib>Limone, P.</creatorcontrib><creatorcontrib>Isaia, G.C.</creatorcontrib><creatorcontrib>Gianotti, L.</creatorcontrib><creatorcontrib>Pollo, A.</creatorcontrib><creatorcontrib>Verde, R.</creatorcontrib><creatorcontrib>Benedetti, F.</creatorcontrib><creatorcontrib>Pinessi, L.</creatorcontrib><title>Decreased Sensitivity of 5-HT1D Receptors in Chronic Tension-Type Headache</title><title>Headache</title><addtitle>Headache: The Journal of Head and Face Pain</addtitle><description>Objective.—To assess the sensitivity of 5‐HT1D receptors in chronic tension‐type headache using sumatriptan as a pharmacological probe.
Background.—Previous studies have suggested involvement of serotonergic systems in chronic tension‐type headache (CTTH), but relevant experimental data are limited. Sumatriptan, a 5‐HT1B/1D receptor agonist, stimulates the release of growth hormone (GH) and inhibits the release of ACTH, cortisol, and prolactin. These effects may be used to explore the function of serotonergic systems in vivo.
Methods.—We measured GH, ACTH, cortisol and prolactin (PRL) plasma concentrations in 15 patients with chronic tension‐type headache and in 18 healthy controls after subcutaneous administration of sumatriptan (6 mg) or placebo.
Results.—Placebo administration had no effect on hormone concentrations. GH and PRL secretion after sumatriptan administration was significantly (P<0.01 and <0.05) altered in CTTH patients in comparison with controls.
Conclusion.—Our results suggest that cerebral serotonergic functions mediated by 5‐HT1D receptors are altered in CTTH.</description><subject>5-HT1D receptors</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Chronic Disease</subject><subject>chronic tension-type headache</subject><subject>Female</subject><subject>Growth Hormone - blood</subject><subject>Growth Hormone - drug effects</subject><subject>Growth Hormone - metabolism</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Prolactin - drug effects</subject><subject>Prolactin - metabolism</subject><subject>Receptor, Serotonin, 5-HT1D</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Receptors, Serotonin - metabolism</subject><subject>Serotonin Receptor Agonists - metabolism</subject><subject>Serotonin Receptor Agonists - pharmacology</subject><subject>sumatriptan</subject><subject>Sumatriptan - metabolism</subject><subject>Sumatriptan - pharmacology</subject><subject>Tension-Type Headache - metabolism</subject><issn>0017-8748</issn><issn>1526-4610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkVtP20AQhVeoCFLgL1T70r453Yv34pdKNAHCRSDAqI-r9e5YbOrYwevQ5N_XJgGeZjTzzZHOHIQwJWNKUvlzPqaCySSV_YARwsaEUcXG6z00-lh8QSNCqEq0SvUh-hrjnJD-NpMH6JAynhHJ-QhdTcG1YCN4_Ah1DF14Dd0GNyUWySynU_wADpZd00Ycajx5bps6OJwPaFMn-WYJeAbWW_cMx2i_tFWEk109Qk_nZ_lkltzcXVxOTm-SwDljibalJbJ0lkOphRCSpU7oVGjrXZpy0EIK6yErfeEzAszrwlEuiVJcFZ4W_Aj92Oou2-ZlBbEzixAdVJWtoVlFo5igSmeyB7_twFWxAG-WbVjYdmPe3ffA9x1go7NV2drahfjJpTSjRIme-7Xl_oUKNp97YoY0zNwMTzfD082QhnlLw6zN7Ox0OrS9QLIVCLGD9YeAbf8a2dsS5s_thfnNrx8fZH5vJvw_lEuLAw</recordid><startdate>200209</startdate><enddate>200209</enddate><creator>Rainero, I.</creator><creator>Valfrè, W.</creator><creator>Savi, L.</creator><creator>Ferrero, M.</creator><creator>Del Rizzo, P.</creator><creator>Limone, P.</creator><creator>Isaia, G.C.</creator><creator>Gianotti, L.</creator><creator>Pollo, A.</creator><creator>Verde, R.</creator><creator>Benedetti, F.</creator><creator>Pinessi, L.</creator><general>Blackwell Science Inc</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200209</creationdate><title>Decreased Sensitivity of 5-HT1D Receptors in Chronic Tension-Type Headache</title><author>Rainero, I. ; Valfrè, W. ; Savi, L. ; Ferrero, M. ; Del Rizzo, P. ; Limone, P. ; Isaia, G.C. ; Gianotti, L. ; Pollo, A. ; Verde, R. ; Benedetti, F. ; Pinessi, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3322-8afa06fca3ef8555624c58458adc443e8565ade9fdbd90e2d8bc13607737bd1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>5-HT1D receptors</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Chronic Disease</topic><topic>chronic tension-type headache</topic><topic>Female</topic><topic>Growth Hormone - blood</topic><topic>Growth Hormone - drug effects</topic><topic>Growth Hormone - metabolism</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Prolactin - drug effects</topic><topic>Prolactin - metabolism</topic><topic>Receptor, Serotonin, 5-HT1D</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Receptors, Serotonin - metabolism</topic><topic>Serotonin Receptor Agonists - metabolism</topic><topic>Serotonin Receptor Agonists - pharmacology</topic><topic>sumatriptan</topic><topic>Sumatriptan - metabolism</topic><topic>Sumatriptan - pharmacology</topic><topic>Tension-Type Headache - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rainero, I.</creatorcontrib><creatorcontrib>Valfrè, W.</creatorcontrib><creatorcontrib>Savi, L.</creatorcontrib><creatorcontrib>Ferrero, M.</creatorcontrib><creatorcontrib>Del Rizzo, P.</creatorcontrib><creatorcontrib>Limone, P.</creatorcontrib><creatorcontrib>Isaia, G.C.</creatorcontrib><creatorcontrib>Gianotti, L.</creatorcontrib><creatorcontrib>Pollo, A.</creatorcontrib><creatorcontrib>Verde, R.</creatorcontrib><creatorcontrib>Benedetti, F.</creatorcontrib><creatorcontrib>Pinessi, L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Headache</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rainero, I.</au><au>Valfrè, W.</au><au>Savi, L.</au><au>Ferrero, M.</au><au>Del Rizzo, P.</au><au>Limone, P.</au><au>Isaia, G.C.</au><au>Gianotti, L.</au><au>Pollo, A.</au><au>Verde, R.</au><au>Benedetti, F.</au><au>Pinessi, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased Sensitivity of 5-HT1D Receptors in Chronic Tension-Type Headache</atitle><jtitle>Headache</jtitle><addtitle>Headache: The Journal of Head and Face Pain</addtitle><date>2002-09</date><risdate>2002</risdate><volume>42</volume><issue>8</issue><spage>709</spage><epage>714</epage><pages>709-714</pages><issn>0017-8748</issn><eissn>1526-4610</eissn><coden>HEADAE</coden><abstract>Objective.—To assess the sensitivity of 5‐HT1D receptors in chronic tension‐type headache using sumatriptan as a pharmacological probe.
Background.—Previous studies have suggested involvement of serotonergic systems in chronic tension‐type headache (CTTH), but relevant experimental data are limited. Sumatriptan, a 5‐HT1B/1D receptor agonist, stimulates the release of growth hormone (GH) and inhibits the release of ACTH, cortisol, and prolactin. These effects may be used to explore the function of serotonergic systems in vivo.
Methods.—We measured GH, ACTH, cortisol and prolactin (PRL) plasma concentrations in 15 patients with chronic tension‐type headache and in 18 healthy controls after subcutaneous administration of sumatriptan (6 mg) or placebo.
Results.—Placebo administration had no effect on hormone concentrations. GH and PRL secretion after sumatriptan administration was significantly (P<0.01 and <0.05) altered in CTTH patients in comparison with controls.
Conclusion.—Our results suggest that cerebral serotonergic functions mediated by 5‐HT1D receptors are altered in CTTH.</abstract><cop>Boston, MA, USA</cop><pub>Blackwell Science Inc</pub><pmid>12390633</pmid><doi>10.1046/j.1526-4610.2002.02172.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0017-8748 |
| ispartof | Headache, 2002-09, Vol.42 (8), p.709-714 |
| issn | 0017-8748 1526-4610 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72517896 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 5-HT1D receptors Adult Biological and medical sciences Brain - metabolism Chronic Disease chronic tension-type headache Female Growth Hormone - blood Growth Hormone - drug effects Growth Hormone - metabolism Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Nervous system (semeiology, syndromes) Neurology Prolactin - drug effects Prolactin - metabolism Receptor, Serotonin, 5-HT1D Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Serotonin Receptor Agonists - metabolism Serotonin Receptor Agonists - pharmacology sumatriptan Sumatriptan - metabolism Sumatriptan - pharmacology Tension-Type Headache - metabolism |
| title | Decreased Sensitivity of 5-HT1D Receptors in Chronic Tension-Type Headache |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T16%3A45%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20Sensitivity%20of%205-HT1D%20Receptors%20in%20Chronic%20Tension-Type%20Headache&rft.jtitle=Headache&rft.au=Rainero,%20I.&rft.date=2002-09&rft.volume=42&rft.issue=8&rft.spage=709&rft.epage=714&rft.pages=709-714&rft.issn=0017-8748&rft.eissn=1526-4610&rft.coden=HEADAE&rft_id=info:doi/10.1046/j.1526-4610.2002.02172.x&rft_dat=%3Cproquest_pubme%3E72517896%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72517896&rft_id=info:pmid/12390633&rfr_iscdi=true |