Melatonin receptor mRNA localization and rhythmicity in the retina of the domestic chick, Gallus domesticus
The indoleamine hormone melatonin is synthesized and released by photoreceptors during the night within the chick retina, and confers timing information to modulate retinal physiology. Three subtypes of melatonin receptor with nearly identical pharmacological profiles have been described in chickens...
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| Veröffentlicht in: | Visual neuroscience 2002-05, Vol.19 (3), p.265-274 |
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| creator | NATESAN, ARJUN K. CASSONE, VINCENT M. |
| description | The indoleamine hormone melatonin is synthesized and released
by photoreceptors during the night within the chick retina,
and confers timing information to modulate retinal physiology.
Three subtypes of melatonin receptor with nearly identical
pharmacological profiles have been described in chickens and
are present in the retina. In this study, the spatial localization
and temporal pattern of the mRNA for each of these receptors
within the retina are described. The localization and rhythmicity
of receptor mRNA were analyzed using in situ hybridization
and RNase protection assay, respectively, with probes against
specific nucleotide sequences encoding these receptors.
Mel1A and Mel1C receptor mRNA have similar
patterns of expression, primarily in the inner segments of
photoreceptors, vitread portion of the inner nuclear layer,
and in the retinal ganglion cell layer. Mel1B receptor
mRNA is expressed at higher levels in the retina, with expression
in photoreceptors, throughout the inner nuclear layer, and in
the ganglion cell layer. Mel1A receptor mRNA is rhythmic
in both light:dark (LD) cycles and in constant darkness (DD);
Mel1A peaks during midday and mid-subjective day,
respectively. Mel1C receptor mRNA is also rhythmically
expressed in LD, but with a lower amplitude, such that transcript
is high during the day and low during the night. In DD,
Mel1C rhythms become 180 deg out of phase with a
slight increase at night. Mel1B mRNA expression was
highly variable and arrhythmic. |
| doi_str_mv | 10.1017/S0952523802192042 |
| format | Article |
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by photoreceptors during the night within the chick retina,
and confers timing information to modulate retinal physiology.
Three subtypes of melatonin receptor with nearly identical
pharmacological profiles have been described in chickens and
are present in the retina. In this study, the spatial localization
and temporal pattern of the mRNA for each of these receptors
within the retina are described. The localization and rhythmicity
of receptor mRNA were analyzed using in situ hybridization
and RNase protection assay, respectively, with probes against
specific nucleotide sequences encoding these receptors.
Mel1A and Mel1C receptor mRNA have similar
patterns of expression, primarily in the inner segments of
photoreceptors, vitread portion of the inner nuclear layer,
and in the retinal ganglion cell layer. Mel1B receptor
mRNA is expressed at higher levels in the retina, with expression
in photoreceptors, throughout the inner nuclear layer, and in
the ganglion cell layer. Mel1A receptor mRNA is rhythmic
in both light:dark (LD) cycles and in constant darkness (DD);
Mel1A peaks during midday and mid-subjective day,
respectively. Mel1C receptor mRNA is also rhythmically
expressed in LD, but with a lower amplitude, such that transcript
is high during the day and low during the night. In DD,
Mel1C rhythms become 180 deg out of phase with a
slight increase at night. Mel1B mRNA expression was
highly variable and arrhythmic.</description><identifier>ISSN: 0952-5238</identifier><identifier>EISSN: 1469-8714</identifier><identifier>DOI: 10.1017/S0952523802192042</identifier><identifier>PMID: 12392176</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Animals ; Animals, Newborn - metabolism ; Biological and medical sciences ; Chickens ; Circadian ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Ganglion cells ; In Situ Hybridization ; Male ; Mel1A ; Mel1B ; Mel1C ; Periodicity ; Photoperiod ; Photoreceptors ; Receptors, Cell Surface - genetics ; Receptors, Cytoplasmic and Nuclear - genetics ; Receptors, Melatonin ; Retina - metabolism ; RNA, Messenger - metabolism ; Tissue Distribution ; Vertebrates: nervous system and sense organs</subject><ispartof>Visual neuroscience, 2002-05, Vol.19 (3), p.265-274</ispartof><rights>2002 Cambridge University Press</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-2bc2f7e77366ad3fa21ab32348dfc5426c35e792e8282ad677b00567fc64003d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0952523802192042/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14023104$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12392176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NATESAN, ARJUN K.</creatorcontrib><creatorcontrib>CASSONE, VINCENT M.</creatorcontrib><title>Melatonin receptor mRNA localization and rhythmicity in the retina of the domestic chick, Gallus domesticus</title><title>Visual neuroscience</title><addtitle>Vis Neurosci</addtitle><description>The indoleamine hormone melatonin is synthesized and released
by photoreceptors during the night within the chick retina,
and confers timing information to modulate retinal physiology.
Three subtypes of melatonin receptor with nearly identical
pharmacological profiles have been described in chickens and
are present in the retina. In this study, the spatial localization
and temporal pattern of the mRNA for each of these receptors
within the retina are described. The localization and rhythmicity
of receptor mRNA were analyzed using in situ hybridization
and RNase protection assay, respectively, with probes against
specific nucleotide sequences encoding these receptors.
Mel1A and Mel1C receptor mRNA have similar
patterns of expression, primarily in the inner segments of
photoreceptors, vitread portion of the inner nuclear layer,
and in the retinal ganglion cell layer. Mel1B receptor
mRNA is expressed at higher levels in the retina, with expression
in photoreceptors, throughout the inner nuclear layer, and in
the ganglion cell layer. Mel1A receptor mRNA is rhythmic
in both light:dark (LD) cycles and in constant darkness (DD);
Mel1A peaks during midday and mid-subjective day,
respectively. Mel1C receptor mRNA is also rhythmically
expressed in LD, but with a lower amplitude, such that transcript
is high during the day and low during the night. In DD,
Mel1C rhythms become 180 deg out of phase with a
slight increase at night. Mel1B mRNA expression was
highly variable and arrhythmic.</description><subject>Animals</subject><subject>Animals, Newborn - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chickens</subject><subject>Circadian</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglion cells</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Mel1A</subject><subject>Mel1B</subject><subject>Mel1C</subject><subject>Periodicity</subject><subject>Photoperiod</subject><subject>Photoreceptors</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cytoplasmic and Nuclear - genetics</subject><subject>Receptors, Melatonin</subject><subject>Retina - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Tissue Distribution</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0952-5238</issn><issn>1469-8714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtv1DAUhS1ERaeFH8AGWUh0RcBvO8tqRIdKbXmvLcdxGHeSeLAdieHX18NELQKxsuzznetz7wXgOUZvMMLy7RdUc8IJVYjgmiBGHoEFZqKulMTsMVjs5WqvH4OTlG4RwhRz-gQcY0JrgqVYgM21600Oox9hdNZtc4hw-HxzDvtgTe9_mezDCM3Ywrje5fXgrc87WOi8dsWR_Whg6H7f2jC4lL2Fdu3t5jVcmb6f0v3zlJ6Co870yT2bz1Pw7eLd1-X76urD6nJ5flVZRkWuSGNJJ52UVAjT0s4QbBpKKFNtZzkjwlLuZE2cIoqYVkjZIMSF7KxgCNGWnoKzQ91tDD-m8rkefLKu783owpS0JLz0rngBX_4F3oYpjiWbxrUinEqmCoQPkI0hpeg6vY1-MHGnMdL7Neh_1lA8L-bCUzO49sExz70Ar2bApDLnLprR-vTAMUQoRqxw1YHzKbuf97qJGy0klVyL1SfN5PLjDbpQelV4Ooc1QxN9-9390dJ_494BSFStAw</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>NATESAN, ARJUN K.</creator><creator>CASSONE, VINCENT M.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Melatonin receptor mRNA localization and rhythmicity in the retina of the domestic chick, Gallus domesticus</title><author>NATESAN, ARJUN K. ; CASSONE, VINCENT M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-2bc2f7e77366ad3fa21ab32348dfc5426c35e792e8282ad677b00567fc64003d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Animals, Newborn - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chickens</topic><topic>Circadian</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglion cells</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Mel1A</topic><topic>Mel1B</topic><topic>Mel1C</topic><topic>Periodicity</topic><topic>Photoperiod</topic><topic>Photoreceptors</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cytoplasmic and Nuclear - genetics</topic><topic>Receptors, Melatonin</topic><topic>Retina - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Tissue Distribution</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NATESAN, ARJUN K.</creatorcontrib><creatorcontrib>CASSONE, VINCENT M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Visual neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NATESAN, ARJUN K.</au><au>CASSONE, VINCENT M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin receptor mRNA localization and rhythmicity in the retina of the domestic chick, Gallus domesticus</atitle><jtitle>Visual neuroscience</jtitle><addtitle>Vis Neurosci</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>19</volume><issue>3</issue><spage>265</spage><epage>274</epage><pages>265-274</pages><issn>0952-5238</issn><eissn>1469-8714</eissn><abstract>The indoleamine hormone melatonin is synthesized and released
by photoreceptors during the night within the chick retina,
and confers timing information to modulate retinal physiology.
Three subtypes of melatonin receptor with nearly identical
pharmacological profiles have been described in chickens and
are present in the retina. In this study, the spatial localization
and temporal pattern of the mRNA for each of these receptors
within the retina are described. The localization and rhythmicity
of receptor mRNA were analyzed using in situ hybridization
and RNase protection assay, respectively, with probes against
specific nucleotide sequences encoding these receptors.
Mel1A and Mel1C receptor mRNA have similar
patterns of expression, primarily in the inner segments of
photoreceptors, vitread portion of the inner nuclear layer,
and in the retinal ganglion cell layer. Mel1B receptor
mRNA is expressed at higher levels in the retina, with expression
in photoreceptors, throughout the inner nuclear layer, and in
the ganglion cell layer. Mel1A receptor mRNA is rhythmic
in both light:dark (LD) cycles and in constant darkness (DD);
Mel1A peaks during midday and mid-subjective day,
respectively. Mel1C receptor mRNA is also rhythmically
expressed in LD, but with a lower amplitude, such that transcript
is high during the day and low during the night. In DD,
Mel1C rhythms become 180 deg out of phase with a
slight increase at night. Mel1B mRNA expression was
highly variable and arrhythmic.</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>12392176</pmid><doi>10.1017/S0952523802192042</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0952-5238 |
| ispartof | Visual neuroscience, 2002-05, Vol.19 (3), p.265-274 |
| issn | 0952-5238 1469-8714 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72517685 |
| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Animals Animals, Newborn - metabolism Biological and medical sciences Chickens Circadian Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Ganglion cells In Situ Hybridization Male Mel1A Mel1B Mel1C Periodicity Photoperiod Photoreceptors Receptors, Cell Surface - genetics Receptors, Cytoplasmic and Nuclear - genetics Receptors, Melatonin Retina - metabolism RNA, Messenger - metabolism Tissue Distribution Vertebrates: nervous system and sense organs |
| title | Melatonin receptor mRNA localization and rhythmicity in the retina of the domestic chick, Gallus domesticus |
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