Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction

Myocardial collagen degradation is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinase (TIMPs). The possible relevance of MMPs in association with the inflammatory induction was investigated in a murine coxsackievirus B3 myocarditis model. Hearts from vira...

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Veröffentlicht in:	Cardiovascular research 2002-11, Vol.56 (2), p.235-247
Hauptverfasser:	JUN LIA, SCHWIMMBECK, Peter Lothar, SPILLMANN, Frank, ZEICHHARDT, Heinz, SCHULTHEISS, Heinz-Peter, PAUSCHINGER, Matthias, TSCHOPE, Carsten, LESCHKA, Sebastian, HUSMANN, Lars, RUTSCHOW, Susanne, REICHENBACH, Florian, NOUTSIAS, Michel, KOBALZ, Ursula, POLLER, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Collagen - metabolism Coxsackievirus Infections - metabolism Cytokines - biosynthesis Cytokines - genetics Disease Models, Animal Down-Regulation Hemodynamics Human viral diseases Immunoenzyme Techniques Infectious diseases Male Matrix Metalloproteinases - biosynthesis Matrix Metalloproteinases - genetics Matrix Metalloproteinases - physiology Medical sciences Mice Mice, Inbred BALB C Myocarditis - metabolism Myocarditis - physiopathology Myocarditis - virology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tissue Inhibitor of Metalloproteinases - biosynthesis Tissue Inhibitor of Metalloproteinases - genetics Up-Regulation Viral cardiopathies Viral diseases
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