Searching Expressed Sequence Tag Databases: Discovery and Confirmation of a Common Polymorphism in the Thymidylate Synthase Gene

Databases of expressed sequence tags (EST) can be used to screen rapidly for potential polymorphisms in candidate proteins. As part of this study, we screened the gene for the enzyme thymidylate synthase (TS). TS is important physiologically because it is essential for the synthesis of deoxythymidyl...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2000-12, Vol.9 (12), p.1381-1385
Hauptverfasser:	ULRICH, Cornelia M, BIGLER, Jeannette, VELICER, Christine M, GREENE, Elizabeth A, FARIN, Federico M, POTTER, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Databases, Factual European Continental Ancestry Group - genetics Expressed Sequence Tags Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Miscellaneous. Technology Molecular Sequence Data Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymorphism, Genetic - genetics Sequence Alignment - methods Thymidylate Synthase - genetics
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